Bio154/254/Neurobio254 is a combined upper-level undergraduate and graduate course. The course focuses on cellular and molecular studies of the organization and function of the nervous system. The lecture content is described in detail below. Lecture hours are Mondays and Wednesdays, 1:15-3:05 pm, in Hewlett 201.
Undergraduate/masters level (154) students will have an additional 50min-long section every week. On weeks 3,5,7 and 9 primary research papers will be discussed. You are required to attend the paper discussions. Other sections are optional.
Graduate level (254) students will have an additional two-hour discussion section every Friday starting Oct. 1, 1:15-3:05 pm, at Gilbert 117; three research papers will be discussed every week. The course website containing lecture PDFs, discussion papers and other course materials can be found at https://coursework.stanford.edu.
PhD students must register for 254 (up to 5 units); master and undergraduate students should register for 154 (4 units).
For Bio154 students:
You will have a weekly section with TAs starting from week 2. In weeks 3, 5, 7 and 9, one research paper each is to be discussed in depth. These discussions contribute towards 20% of the grade. 40% of the grade will be from a term paper due on Friday noon Nov. 19. The rest 40% will be from a final exam on Dec 10th .
For Bio254 students:
Each week three primary research papers (PDFs posted on the coursework website) need to be read in advance and are discussed in depth. Discussion sections count towards 50% of the grade. Another 50% comes from a Ògrant proposalÓ due by noon on Dec 10th .
By the end of the lecture day, the entire presentation will be available in PDF to all registered students on the CourseWork website.
Reference books (reserved at Falconer Library):
Kandel et al. Principles of Neural Science (2000)
Squire et al., Fundamental Neuroscience (2008)
No books could replace the lectures per se.
Therefore lecture attendance is essential!
1. Mon Sept 20 Overview of nervous system organization Luo
2. Wed Sept 22 Action potential Shen
3. Mon Sept 27 Synaptic transmission Shen
4. Wed Sept 29 Synapse development Shen
Fri Oct 1 Discussion: Synapse Luo/Shen
5. Mon Oct 4 Signal transduction Clandinin
6. Wed Oct 6 Vision 1 Clandinin
Fri Oct 8 Discussion: Transduction Clandinin/Luo
7. Mon Oct 11 Vision 2 Clandinin
8. Wed Oct 13 Vision 3 Clandinin
Fri Oct 15 Discussion: Vision Clandinin/Luo
9. Mon Oct 18 Olfaction 1 Luo
10. Wed Oct 20 Olfaction 2 Luo
. Fri Oct 22 Discussion: Olfaction Clandinin/Luo
11. Mon Oct 25 Circadian rhythm and sleep Luo
12. Wed Oct 27 Sexual behavior Luo
Fri Oct 29 Discussion: Time/Love Luo/Shen
13. Mon Nov 1 Learning and memory 1 Shen
14. Wed Nov 3 Learning and memory 2 Shen
Fri Nov 5 Discussion: Learning/Memory Clandinin/Shen
15. Mon Nov 8 Neurological diseases Shen
16. Wed Nov 10 Evolution of the nervous system Clandinin
Fri Nov 12 No grad discussion: SfN meeting
Mon Nov 15 No class: SfN meeting
17. Wed Nov 17 Future of neuroscience: guided discussion Clandinin/Luo/Shen
Fri Nov 19 Discussion: Disease/Evolution Clandinin/Shen
Papers for graduate discussions:
Oct 1 (synapse):
Xu J, Pang ZP, Shin OH, Sdhof TC.
Nat Neurosci. 2009 Jun;12(6):759-66.
Matsuda K, Miura E, Miyazaki T, Kakegawa W, Emi K, Narumi S, Fukazawa Y, Ito-Ishida A, Kondo T, Shigemoto R, Watanabe M, Yuzaki M.
Science. 2010 Apr 16;328(5976):363-8.
Linhoff MW, Laurn J, Cassidy RM, Dobie FA, Takahashi H, Nygaard HB, Airaksinen MS, Strittmatter SM, Craig AM.
Neuron. 2009 Mar 12;61(5):734-49.
Oct. 8 (transduction):
Kang L, Gao J, Schafer WR, Xie Z, Xu XZ.
Neuron. 2010 Aug 12;67(3):381-91.
Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong X.
Cell. 2009 Dec 24;139(7):1353-65. Epub 2009 Dec 10.
Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, Wu J, Harmin DA, Laptewicz M, Barbara-Haley K, Kuersten S, Markenscoff-Papadimitriou E, Kuhl D, Bito H, Worley PF, Kreiman G, Greenberg ME.
Nature. 2010 May 13;465(7295):182-7. Epub 2010 Apr 14
Oct. 15 (vision):
Triplett JW, Owens MT, Yamada J, Lemke G, Cang J, Stryker MP, Feldheim DA.
Cell. 2009 Oct 2;139(1):175-85.
Niell CM, Stryker MP.
Neuron. 2010 Feb 25;65(4):472-9.
Ecker JL, Dumitrescu ON, Wong KY, Alam NM, Chen SK, LeGates T, Renna JM, Prusky GT, Berson DM, Hattar S.
Neuron. 2010 Jul 15;67(1):49-60.
Oct. 22 (olfaction):
Tan J, Savigner A, Ma M, Luo M.
Neuron. 2010 Mar 25;65(6):912-26.
Semmelhack JL, Wang JW.
Nature. 2009 May 14;459(7244):218-23.
Papes F, Logan DW, Stowers L.
Cell. 2010 May 14;141(4):692-703.
Oct. 29 (love):
Haga S, Hattori T, Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, Touhara K.
Nature. 2010 Jul 1;466(7302):118-22.
Wu MV, Manoli DS, Fraser EJ, Coats JK, Tollkuhn J, Honda S, Harada N, Shah NM.
Cell. 2009 Oct 2;139(1):61-72.
Gregg C, Zhang J, Butler JE, Haig D, Dulac C.
Science. 2010 Aug 6;329(5992):682-5. Epub 2010 Jul 8.
Nov. 5 (learning and memory):
Okada D, Ozawa F, Inokuchi K.
Science. 2009 May 15;324(5929):904-9.
Claridge-Chang A, Roorda RD, Vrontou E, Sjulson L, Li H, Hirsh J, Miesenbck G.
Cell. 2009 Oct 16;139(2):405-15. Erratum in: Cell. 2009 Nov 25;139(5):1022.
Whitlock JR, Heynen AJ, Shuler MG, Bear MF.
Science. 2006 Aug 25;313(5790):1093-7.
Nov. 19 (evolution and diseases):
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M.
Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH.
Cell. 2009 Mar 20;136(6):1017-31.
Kang K, Pulver SR, Panzano VC, Chang EC, Griffith LC, Theobald DL, Garrity PA.
Nature. 2010 Mar 25;464(7288):597-600. Epub 2010 Mar 17.
Maintained by Egle Cekanaviciute (firstname.lastname@example.org)