BIO Core Experimental Laboratory

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Course News

Dear Students,

Thank you for your interest in taking the Bio Core Lab Classes! Please sign up early since these classes fill up quickly!

BIO45, BIO46 & BIO47 have a lab fee, carry 4 units of credit, and are graded Satisfactory/No Credit.

Although there are no pre-requisites to enroll in this class, having taken CHEM 31X, or 31A and B, and 33 and being concurrently enrolled or past enrollment in appropriate Biology Foundation classes or HumBio core classes is recommended. Check the Biology Department website for lab classes offered at Hopkins Marine Station. If you have any questions, please feel free to contact the Student Services Office.

BIO45 DOES NOT fulfill the WIM requirement for any major, but BIO46 & BIO47 FULFILL the Writing-In-The-Major requirement for the Biology major.

For questions NOT answered here, please contact the Course Director Dr. Shyamala Malladi (smalladi@stanford.edu).

Thank you,

BIO Core Experimental Laboratory Course Staff

BIO 45 - Fall Quarter and Winter Quarter (4 units, P/NP)

Introduction to laboratory research in cell and molecular biology

Investigate yeast strains that are engineered to express the human tumor suppressor protein, p53, and use modern molecular biology methods to identify the functional consequences of p53 mutations isolated from tumor cells. Learn about the protein's role as “Guardian of the Genome” through lectures and by reading and discussing journal articles. Use molecular visualization programs to examine the structure of normal and mutant p53 proteins. Assay the ability of mutant p53 to direct expression of several reporter genes. During guided reflection, investigate further and identify what could be wrong with the p53 mutants you have been studying. Conduct lab experiments to test hypotheses, analyze data, and present your findings through a team oral presentation, as well as a scientific poster. Although there are no pre-requisites to enroll in this class, having taken CHEM 31X, or 31A and B, and 33 and being concurrently enrolled or past enrollment in appropriate Biology Foundation classes or HumBio core classes is recommended.

Note: This class has a $25 course fee.
This class does not fulfill the WIM requirement.

BIO 46 - Winter Quarter (4 units, P/NP)

Introduction to Research in Ecology and Evolutionary Biology

The goal of this course is to develop an understanding of how to conduct biological research, using a topic in Ecology, Evolutionary Biology, and Plant Biology as a practical example. This includes the complete scientific process: assessing background literature, generating testable hypotheses, learning techniques for field- and lab-based data collection, analyzing data using appropriate statistical methods, and finally writing and sharing results. To build these skills, this course will focus on a topic in Ecology, Evolutionary Biology and / or Plant Biology. Students, working in teams, will develop novel research hypotheses and execute the necessary experiments and measurements to test these hypotheses. The capstone of the course will be an oral defense of students' findings, as well as a research paper in the style of a peer-reviewed journal article. Labs will be completed both on campus and at Jasper Ridge.

Note: This class has a $25 course fee.
This course FULFILLS the Writing-In-The-Major requirement for the Biology major.

This course requires fieldwork in addition to the classroom laboratory work--this means that you may be spending a large fraction of the lab time in the field at Jasper Ridge Biological Preserve. Please note that some wild flowers may be in bloom during winter quarter which may be allergenic to some individuals. Additionally, much of the fieldwork requires hiking around the preserve - if you require any accommodations to do the fieldwork, please contact us in advance.

BIO47 - Spring Quarter (4 units, P/NP)

Introduction to Research in Ecology and Evolutionary Biology

The goal of this course is to develop an understanding of how to conduct biological research, using a topic in Ecology, Evolutionary Biology, and Plant Biology as a practical example. This includes the complete scientific process: assessing background literature, generating testable hypotheses, learning techniques for field- and lab-based data collection, analyzing data using appropriate statistical methods, and finally writing and sharing results. To build these skills, this course will focus on communities of microorganisms living in floral nectar at Stanford's nearby Jasper Ridge Biological Preserve. Students, working in teams, will develop novel research hypotheses and execute the necessary experiments and measurements to test these hypotheses. The capstone of the course will be an oral defense of students' findings, as well as a research paper in the style of a peer-reviewed journal article. Labs will be completed both on campus and at Jasper Ridge.

Note: This class has a $25 course fee.
This course FULFILLS the Writing-In-The-Major requirement for the Biology major.

This course requires fieldwork in addition to the classroom laboratory work--this means that you may be spending a large fraction of the lab time in the field at Jasper Ridge Biological Preserve. The spring quarter also coincides with flowering that should be considered if you have any allergies. Additionally, much of the fieldwork requires hiking around the preserve - if you require any accommodations to do the fieldwork, please contact us in advance.