History

Timeline of Discovery of F. hepatica

De Brie, 1379      First observation of cercariae in snail
Swammerdam, 1737      First observation of F. hepatica
Muller, 1773     Cercariae were seen in water
Zeder, 1803       Life cycle was described including the hatching of egg
Nitzsch, 1807     The encysting of cercariae was studied
Steenstrup, 1842   Elucidated the idea of an alternating generation in parasite development
Weinland, 1875   L. truncatula was determined as the intermediate host for the larval stage of the liver fluke
Leuckart 1882 First to describe the life cycle of F. hepatica and confirm its host
Lutz, 1892     Elucidated the mode of transmission of the parasites to herbivores
Sinitsin, 1914  etermined the route of transmission to humans and D organ damage caused by the parasite.

 Source: Andrews, SJ. The Life Cycle of Fasciola hepatica. CAB International, 1999. <http://www.cabipublishing.org/pdf/Books/0851992609/2609ch1.pdf>

Discovery of Fasciola gigantica


In the 1875 issue of the Lancet J.F.P McConnell, a physician and pathologist in Calcutta, described the morphology, anatomy, and pathogenesis of a new live fluke which he was able to isolate from an infected Chinese man.

 

McConnell’s Illustration of the F. gigantica Anatomy


Source: McConnell, JFP. Anatomy and Pathological Relations of a New Species of Liver-fluke. The Lancet 1875 Aug: 271.

Description of the New Liver Fluke

 

Source: McConnell, JFP. Anatomy and Pathological Relations of a New Species of Liver-fluke. The Lancet 1875 Aug: 271.