ANTI-MALARIAL DRUG DEVELOPMENT EFFORTS
I. INTRODUCTION TO MALARIA
Malaria is a parasite that has plagued the world for centuries. According to the World Health Organization's 2005 report, the annual mortality due to malaria is approximately 2.5 million. The majority of these cases are pediatric deaths in developing countries, which exemplifies the tragedy of the disease caused by this parasite.
There are four species of malaria or the genus Plasmodium, which include Plasmodium falciparum, P. vivax, P. ovale, and P. malariae. The foremost killer; however, is Plasmodium falciparum and is found primarily on the African continent. Malaria is transmitted to and from humans by the female Andopheles mosquito.
Unlike some infectious diseases whose frequency are declining, due to prevention efforts and scientific advances in treatment and vaccines, malaria prevalence continues to rise due to wide-spread resistance to many of the current drugs (Weisman et al. 2006). There are no successful malaria vaccines.Links to Previous ParaSites can be found at: