Bioe225/Rad225: Intro to Ultrasound Imaging and Therapeutic Applications

Lecture Notes, Reading Assignments, Announcements

Sept 14 – Introduction to the Course (Competing neuromod modalities, need for ultrasound neuromodulation, short history)

Sept 16 – Fundamentals of Pressure Waves (pressure, speed of sound, frequency content of a pulse, review FT key concepts, Fourier Shift Theorem)

Sept 18 – Acoustic Properties of Biological Tissue I (attenuation, absorption, scattering, particle reflection, intensity)

Sept 21 – Acoustic Properties of Biological Tissue II (acoustic impedance, reflection and refraction, interfaces, coupling cones, gel, hair)

Sept 23 – Transducer Hardware (Piezoelectric effect, matching layers, BW, backing, Q, f number)

Sept 25 – Single Element Transducers (side lobes, near field and far field, focal spot size and dimensions)

Sept 28 – Arrays (grating lobes, Fourier shift theorem, beam steering)

Sept 30 – Skulls (properties, modeling for predicting focal spot + PAC, printed lenses)

Oct 2 – Temperature (absorption, intensity, hydrophones, TI, Ispta, Isppa, FDA limit, pulsing schemes)

Oct 5 – Clinical ET Treatments (MR thermometry, temperature modeling)

Oct 7 – Radiation Pressure (MR-ARFI, intensity at the focus, hydrophones)

Oct 9 – Nonlinearity and Cavitation (MI, CI, FDA limit, degassed water)

Oct 12 – Additional Considerations (Shear waves, auditory effects, standing waves, electrode displacement)

Oct 14 – Neuronal Physiology (resting membrane potential, neuron anatomy, action potentials)

Oct 16 – Ultrasound acting on Neurons

Oct 19 – Mechanosensory Biology I (systems level)

Oct 21 – Mechanosensory Biology II (ion channel level)

Oct 23 – Animal Model Studies I

Oct 26 – Animal Model Studies II

Oct 28 – Motor Manipulation and Epilepsy

Oct 30 – Manipulation of Behavior in NHP

Nov 2 – Ultrasound effect on Brain Waves

Nov 4 – Brain Network Effects of TUS in NHP

Nov 6 – Pain and neuropathy

Nov 9 – Non-neuronal modulation

Nov 11 – Genetically Modified Enhancements

Nov 13 – Nanoparticle drug delivery

Nov 16 – Microbubbles and BBB opening and drug delivery for neuromodulation

Nov 18 – Student Presentations

Nov 20 – Wrap Up