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Fluorides (inorganic)
NaF: CAS 7681-49-4 |
NaF: mp 993 °C, bp 1700 °C
Slightly soluble to insoluble in water |
Odorless |
LD50 oral (rat) 245 mg/kg (potassium fluoride)
52 mg/kg (sodium fluoride)
377 mg/kg (stannous fluoride) PEL (OSHA) 2.5 mg/m 3 TLV-TWA (ACGIH) 2.5 mg/m 3 |
Moderate acute toxicity; irritating to eyes and respiratory tract. |
The acute toxicity of fluorides is generally moderate. High exposures may cause irritation of the eyes and respiratory tract. Ingestion of fluoride may cause a salty or soapy taste, vomiting, abdominal pain, diarrhea, shortness of breath, difficulty in speaking, thirst, weak pulse, disturbed color vision, muscular weakness, convulsions, loss of consciousness, and death. In humans the approximate lethal dose of NaF by ingestion is 5 g. Repeated inhalation of fluoride dust may cause excessive calcification of the bone and calcification of ligaments of the ribs, pelvis, and spinal column. Repeated skin contact may cause a rash. Fluorides have not been shown to be carcinogenic or to show reproductive or developmental toxicity in humans. |
Fluorides are not combustible. |
Contact with strong acids may cause formation of highly toxic and corrosive hydrogen fluoride. |
Fluorides should be handled in the laboratory using the "basic prudent practices" described in Chapter 5.C. |
In the event of skin contact, immediately wash with soap and water and remove contaminated clothing. In case of eye contact, promptly wash with copious amounts of water for 15 min (lifting upper and lower lids occasionally) and obtain medical attention. If fluorides are ingested, obtain medical attention immediately. If large amounts of fluorides are inhaled, move the person to fresh air and seek medical attention at once. In the event of a spill, sweep up fluorides, place in an appropriate container, and dispose of properly. Respiratory protection may be necessary in the event of a large spill or release in a confined area. |
Excess fluorides and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines. |
The information in this LCSS has been compiled by a committee
of the National Research Council from literature sources and Material
Safety Data Sheets and is believed to be accurate as of July 1994.
This summary is intended for use by trained laboratory personnel
in conjunction with the NRC report Prudent
Practices in the Laboratory: Handling and Disposal of Chemicals. This LCSS presents a concise
summary of safety information that should be adequate for most
laboratory uses of the title substance, but in some cases it may
be advisable to consult more comprehensive references. This information
should not be used as a guide to the nonlaboratory use of this
chemical.
Copyright 1995 National Academy of Sciences. All rights reserved.
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