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Imuran (azathioprine)

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 Metabolized to 6-mercaptopurine which interferes with purine synthesis thus blocking new DNA synthesis necessary for rapidly dividing cells.

 Decreases proliferation of rapidly dividing cells nonspecifically

 Side effects:

Thrombocytopenia
 Leukopenia
 Megaloblastic anemia
 Pancreatitis
 Hepatitis

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