Hopkins Marine Station Student Paper

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(full paper is archived in the Miller Library)

Title: External acidic pH causes metaphase arrest and inhibits histone H1 kinase inactivation in the sea urchin embryo
Student Author(s): D'Amico, Leonard
Faculty Advisor(s): Epel, David
Pages: 17
Location: Final Papers Biology 175H
Date: June 1991
Abstract: The development of sea urchin eggs in a 6.7 pH buffer causes slowed progression through mitosis with eventual arrest in metaphase and sustained levels of Histone H1 Kinase activity. A pH sensitive step or a number of steps must exist in the pathway for inactivation of MPF or histone H1 Kinase, probably by effecting the destruction of cyclin. The developing eggs were arrested at metaphase because the signal for progression through anaphase, MPF inactivation, never appeared.