(full paper is archived in the Miller Library)
Title: MXR activity in coelomic, immature, and fertilized oocytes of Urechis caupo
Student Author(s): Chen, Joyce
Faculty Advisor(s): Epel, David
Location: Final Papers Biology 175H
Date: June 1993
Abstract: The marine worm Urechis caupo exhibits a multixenobiotic resistance (MXR) similar to multidrug resistance (MDR) in mammalian tumor cells. Urechis oocytes from their developing stages in the coelomic fluid to at least the two day larval stage possess a membranous protein of 160 kD that is immunologically related to the mammalian MDR P-glycoprotein of 170 kD. However, activity of the 160 kD protein is absent in developing coelomic oocytes but is detected once the oocytes reach the storage organs as immature oocytes. Further studies are necessary to investigate the causes for the activity increase of the MXR protein at this stage.