Moerner

W. E. Moerner

Harry S. Mosher Professor of Chemistry
Professor of Applied Physics by Courtesy

Description

Biophysics

We optically probe single copies of fluorescent molecules in solution and in living cells, one at a time, with a combination of single-fluorophore labeling, active-control superresolution microscopy, stimulated emission depletion microscopey, FRET/polarization studies, and fluctuation analysis. In collaboration with appropriate biologists in the BioX program, we seek to understand the dynamical behavior of single biomolecules such as chaperonins when ensemble averaging is removed, and we are measuring the protein localization patterns both in bacteria and in eukaryotic cells. A new kind of trap we have invented, the ABEL trap, allows us to grab and manipulate single biomolecules in solution for extended analysis.

Nanoscience and Quantum Engineering

We optically probe single copies of fluorescent molecules in solution and in living cells, one at a time, with a combination of single-fluorophore labeling, active-control superresolution microscopy, stimulated emission depletion microscopey, FRET/polarization studies, and fluctuation analysis. In collaboration with appropriate biologists in the BioX program, we seek to understand the dynamical behavior of single biomolecules such as chaperonins when ensemble averaging is removed, and we are measuring the protein localization patterns both in bacteria and in eukaryotic cells. A new kind of trap we have invented, the ABEL trap, allows us to grab and manipulate single biomolecules in solution for extended analysis.

Courses Taught