Cystic Fibrosis Research Laboratory
Jordan Hall, Bldg. 420
Stanford, CA 94305-2130
Telephone: (650) 725-2468 Fax: 725-5699
Education and Training
B.S. Pfeiffer University, Misenheimer, NC 1989, Department of Sports Medicine and Management
M.S. Appalachian State University, Boone, NC 1991, Department of Health, Leisure, and Exercise Science with training under the supervision of Michael H. Stone, Ph.D.
Ph.D. East Carolina University, Greenville, NC 1996, Department of Physiology with training under the supervision of Michael R. Van Scott, Ph.D.
Postdoctoral Stanford University, Stanford, CA 1996, Cystic Fibrosis Research Laboratory with training under the supervision of Jeffrey J. Wine, Ph.D.
I am interested in the possibility that HCO3- passes through the cystic fibrosis transmembrane conductance regulator (CFTR) and modifies the extracellular pH. To answer this question, I have used cultured epithelial cells and evaluated changes in pH, Isc and membrane properties.
I also have an interest in cellular maturation/differentiation. Ongoing studies are examining the question of whether transformed epithelial cells can be induced to behave similar to their native counterparts. These studies involve a collaboration with Geron Corporation.
American Physiological Society
Fibrosis Foundation, "CFTR and ion transport in simian airways" C.M.
Penland, Ph.D., P.I.
Two presentations to high school students encouraging participation in science, Benson, NC and Greenville, NC 1994.
Participation in SKIP program and supporter of Campus After Dark at San Mateo First Baptist Church, San Mateo, CA
Awards & Recognition
American Physiological Society (Respiration Section) 1995 Proctor & Gamble Professional Opportunity Award in recognition of: Penland, C.M., and Van Scott, M.R. Bicarbonate secretion across Clara cells. Experimental Biology '95. (1995).
Invited speaker at 1996 World Congress on In Vitro Biology, San Francisco, CA. Lecture title: Culture Techniques for Evaluating Bronchiolar Epithelial Cell Function.
Round table leader at 1997 North American Cystic Fibrosis Conference, Nashville, TN. Topic: Clara cells.