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Molecular Bioengineering for Medicine and Biotechnology -- the Barron Group The Barron Group @ Stanford
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Chronological Research
Bioseparations Publications
The following publications are listed in reverse chronological order:
Hestekin CN, Lin JS, Senderowicz L, Jakupciak JP, O’Connell C, Rademaker A, Barron AE, “Blinded study determination of high sensitivity and specificity microchip electrophoresis-SSCP/HA to detect mutations in the p53 gene,” Electrophoresis 2011, 32, 2921-2929. pdf reprint
Sun M, Lin JS, Barron AE, “Ultrafast, efficient separations of large-sized dsDNA in a blended polymer matrix by microfluidic chip electrophoresis: A design of experiments approach,” Electrophoresis 2011, 32, 3233-3240. pdf reprint
Niedringhaus TP, Milanova D, Kerby MB, Snyder MP, Barron AE, “Landscape of next-generation sequencing technologies,” Anal Chem. 2011, 83, 4327-41. pdf reprint
Albrecht JC, Kerby MB, Niedringhaus TP, Lin JS, Wang X, Barron AE, “Free-solution electrophoretic separations of DNA-drag-tag conjugates on glass microchips with no polymer network and no loss of resolution at increased electric field strength,” Electrophoresis 2011, 32, 1201-8. pdf reprint
Lu X, Sun M, Barron AE, “Non-ionic, thermo-responsive DEA/DMA nanogels: synthesis, characterization, and use for DNA separations by microchip electrophoresis,” Journal of Colloid and Interface Science 2011, 357, 345-353. pdf reprint
Root BE, Agarwal AK, Kelso DM, Barron AE, “Purification of HIV RNA from serum using a polymer capture matrix in a microfluidic device,” Analytical Chemistry 2011, 83, 982-988. pdf reprint
Albrecht JC, Lin JS, Barron AE, “A 265-base DNA sequencing read by capillary electrophoresis with no separation matrix,” Analytical Chemistry 2011, 83, 509-515. pdf reprint
Root BE, Zhang B, Barron AE, “Size-based protein separations by microchip electrophoresis using an acid-labile surfactant as a replacement for SDS”, Electrophoresis 2009, 30, 2117–2122. pdf reprint
Forster RE, Hert DG, Chiesl TN, Fredlake CP, Barron AE, “DNA migration mechanism analyses for applications in capillary and microchip electrophoresis”, Electrophoresis 2009, 30, 2014–2024. pdf reprint
Sinville R, Coyne J, Meagher RJ, Cheng Y, Barany F, Barron AE, Soper EA, “Ligase detection reaction for the analysis of point mutations using free-solution conjugate electrophoresis in a polymermicrofluidic device”, Electrophoresis 2008, 29, 4751–4760. pdf reprint
Root BE, Hammock ML, Barron AE, “Thermoresponsive N-alkoxyalkylacrylamide polymers as a sieving matrix for high resolution DNA separations on a microfluidic chip”, Electrophoresis 2008, 29, 4677–4683. pdf reprint
Forster RE, Chiesl TN, Fredlake CP, White CV, Barron AE, "Hydrophobically modified block copolymers for fast, high-resolution DNA sequencing in microfluidic chips," Electrophoresis, 2008, 29, 4669-4676. pdf reprint
Hert DG, Fredlake CP, Barron AE, “DNA sequencing by microchip electrophoresis using mixtures of highand low-molar mass poly(N,Ndimethylacrylamide) matrices”, Electrophoresis 2008, 29, 4663–4668. pdf reprint
Fredlake CP, Hert DG, Root BE, Barron AE, “Polymer systems designed specifically for DNA sequencing by microchip electrophoresis: A comparison with commercially available materials”, Electrophoresis 2008, 29, 4652–4662. pdf reprint
Hert D G, Fredlake C P, Barron AE, “Advantages and limitations of next generation sequencing technologies: A comparison of electrophoresis and non-electrophoresis methods”, Electrophoresis 2008, 29, 4618–4626. pdf reprint
Barron AE, “Editorial: DNA Sequencing and Genotyping”, Electrophoresis 2008, 29, 4617. pdf reprint
Meagher RJ, Won JI, Coyne JA, Lin J, Barron AE, "Sequencing of DNA by free-solution capillary electrophoresis using a genetically engineered protein polymer drag-tag", Anal. Chem. 2008, 80, 2842-2848. pdf reprint
Fredlake CP, Hert DG, Kan CW, Chiesl TN, Root BE, Forster RE, Barron AE, "Ultra-fast DNA sequencing on a microchip by a hybrid separation mechanism that gives 600 bases in 6.5 minutes," PNAS 2008, 105: 476-481. pdf reprint
S.A. Greenspoon, S.H.I. Yeung, K.R. Johnson, W.K. Chu, H.N. Rhee, A.B. McGuckian, C.A. Crouse, T.N. Chiesl, A.E. Barron, J.R. Scherer, J.D. Ban, R.A. Mathies , "A forensic laboratory tests the Berkeley microfabricated capillary array electrophoresis device, J. Forensic Sci. 2008, 53, 828-837. pdf reprint
Nedelcu S, Meagher RJ, Barron AE, Slater GW, "Electric and hydrodynamic stretching of DNA-polymer conjugates in free-solution electrophoresis", Journal of Chemical Physics, 2007, 126: 175104. pdf reprint
Chiesl TN, Forster RE, Root BE, Larkin M, Barron AE, "Stochastic Single-Molecule Videomicroscopy Methods To Measure Electrophoretic DNA Migration Modalities in Polymer Solutions above and below Entanglement," Anal Chem 2007, 79: 7740-7747. pdf reprint
Meagher RJ, Coyne JA, Hestekin CN, Chiesl TN, Haynes RD, Won JI, Barron AE, "Multiplexed p53 mutation detection by free-solution conjugate microchannel electrophoresis with polyamide drag-tags, Analytical Chemistry, 2007, 79: 1848-1854. pdf reprint
Thomas N. Chiesl, Karl Putz, Meena Babu, Patrick Mathias, Kashan A. Shaikh, Edgar D. Goluch, Chang Liu, Annelise E. Barron, "Self-associating block copolymer networks for microchip electrophoresis provide enhanced DNA separation via 'inchworm' chain dynamics.", Analytical Chemistry, 2006, 78, 4409-4415 pdf reprint
Christa N. Hestekin, John P. Jakupciak, Thomas N. Chiesl, Cheuk Wai Kan, Catherine D. O'Connell, Annelise E. Barron, "An optimized microchip electrophoresis system for mutation detection by tandem SSCP and heteroduplex analysis for p53 gene exons 5-9", Electrophoresis, 2006, 27, 3823-3835 pdf reprint
Hestekin CN, Barron AE, "The potential of electrophoretic mobility shift assays for clinical mutation detection", Electrophoresis, 2006, 27: 3805-3815 pdf reprint
Fredlake CP, Hert DG, Mardis ER, Barron AE, "What is the future of electrophoresis in large-scale genomic sequencing?", Electrophoresis, 2006, 27: 3689-3702. pdf reprint
Meagher RJ, McCormick LC, Haynes RD, Won JI, Lin JS, Slater GW, Barron AE, "Free-solution electrophoresis of DNA modified with drag-tags at both ends," Electrophoresis 2006, 27: 1702-1712. pdf reprint
Edgar D. Goluch, Jwa-Min Nam, Kashan A. Shaikh, Kee Suk Ryu, Thomas N. Chiesl, Annelise E. Barron, Chad A. Mirkin, and Chang Liu, "A Bio-Barcode Assay for On-Chip Attomolar-Sensitivity Protein Detection.", Lab on a Chip , 2006, 6, 1293-1299 pdf reprint
Shaikh KA, Ryu KS, Goluch ED, Nam JM, Liu J, Thaxton CS, Chiesl TN, Barron AE, Lu Yi, Mirkin CA, Liu Chang, "A modular microfluidic architecture for integrated biochemical analysis," Proc. Natl. Acad. Sci. 2005, 102: 9745-9750. pdf reprint
Endo Y, Zhang L, Katashima R, Itakura M, Doherty EAS, Barron AE, Baba Y, "Effect of polymer matrix and glycerol on rapid single-strand conformation polymorphism analysis by capillary and microchip electrophoresis for detection of mutations in the K-ras gene," Electrophoresis 2005, 26: 3380-3386. pdf reprint
Won JI, Meagher RJ, Barron AE, "Protein polymer drag-tags for DNA separations by End-Labeled Free-Solution Electrophoresis (ELFSE)," Electrophoresis 2005, 26: 2138-2148. pdf reprint
Haynes RD, Meagher RJ, Won JI, Bogdan FM, Barron AE, "Comb-like, monodisperse polypeptoid drag-tags for DNA separations by End-Labeled Free-Solution Electrophoresis (ELFSE)," Bioconjugate Chemistry 2005, 16: 929-938. pdf reprint
Chiesl TN, Shi W, Barron AE, "Poly (acrylamide-co-alkylacrylamides) for electrophoretic DNA purification in microchannels," Anal. Chem. 2005, 77: 772-779. pdf reprint
Won JI, Meagher RJ, Barron AE, "Characterization of glutamine deamidation in a long, repetitive protein polymer via bioconjugate capillary electrophoresis," Biomacromolecules 2004, 5: 618-627. pdf reprint
Meagher RJ, Won JI, McCormick LC, Nedelcu S, Bertrand M, Bertram JL, Drouin G, Barron AE, Slater GW, "End-Labeled Free-Solution Electrophoresis (ELFSE) of DNA," Electrophoresis 2005, 26: 331-350 (review article). pdf reprint
Doherty EAS, Kan CW, Paegel BM, Yeung SHI, Cao ST, Mathies RA, Barron AE, "Sparsely cross-linked 'nanogel' matrices as fluid, mechanically stabilized polymer networks for high-throughput microchannel DNA sequencing," Anal.Chem. 2004, 76: 5249-5256. pdf reprint
Kan CW, Fredlake, CP, Doherty EAS, Barron AE, "DNA sequencing and genotyping in miniaturized electrophoresis systems," Electrophoresis 2004, 25: 3564-3588. pdf reprint
Buchholz BA, Zahn JM, Kenward M, Slater GW, Barron AE, "Flow-induced chain scission as a physical route to narrowly distributed, high molar mass polymers," Polymer 2004, 45: 1223-1234. pdf reprint
Kan CW, Doherty EAS, Buchholz BA, Barron AE, "Thermoresponsive N,N-dialkylacrylamide copolymer blends as DNA sieving matrices with a thermally tunable mesh size," Electrophoresis 2004, 25: 1007-1015. pdf reprint
Meagher RJ, Seong J, Laibinis PE, Barron AE, "A very thin coating for capillary zone electrophoresis of proteins based on a tri(ethylene glycol)-terminated alkyltrichlorosilane," Electrophoresis 2004, 25: 405-414. pdf reprint
Doherty EAS, Kan CW, Barron AE, 'Sparsely cross-linked "nanogels" for microchannel DNA sequencing,' Electrophoresis 2003, 24: 4170-4180. pdf reprint
Kan CW, Doherty EAS, Barron AE, "A novel thermo-gelling matrix for microchannel DNA sequencing based on poly-N-alkoxyalkylacrylamide copolymers," Electrophoresis 2003, 24: 4161-4169. pdf reprint
Vreeland WN, Williams SJ, Barron AE, and Sassi AP, "Tandem isotachophoresis-zone electrophoresis via base-mediated destacking for increased detection sensitivity in microfluidic systems," Anal. Chem. 2003, 75: 3059-3065. pdf reprint
Albarghouthi MN, Stein TM, Barron AE, "Poly-N-hydroxyethylacrylamide as a novel, adsorbed coating for protein separation by capillary electrophoresis," Electrophoresis 2003, 24: 1166-1175. pdf reprint
Kourkine IV, Ristic-Petrovic M, Davis E, Ruffolo C, Barron AE, "Detection of E. Coli O157:H7 bacteria by a combination of immunofluorescent staining and capillary electrophoresis," Electrophoresis 2003, 24: 655-661. pdf reprint
Kan CW, Barron AE, "A DNA sieving matrix with thermally tunable mesh size," Electrophoresis 2003, 24: 55-62. pdf reprint
Doherty EAS, Meagher RJ, Albarghouthi MN, Barron AE, "Microchannel wall coatings for protein separations by capillary and chip electrophoresis," Electrophoresis 2003, 24: 34-54. pdf reprint
Won JI, Barron AE, "A new cloning method for the preparation of long, repetitive polypeptides without a sequence requirement," Macromolecules 2002, 35: 8281-8287. pdf reprint
Vreeland WN, Meagher RJ, Barron AE, 'Multiplexed, high-throughput genotyping by single-base extension and End-Labeled Free-Solution Electrophoresis (ELFSE),' Anal. Chem. 2002, 74: 4328-4333. pdf reprint
Doherty EAS, Berglund KD, Buchholz BA, Kourkine IV, Tilton RD Barron AE, "Critical factors for high-performance physically adsorbed (dynamic) polymeric wall coatings for microchannel electrophoresis of DNA," Electrophoresis 2002, 23: 2766-2776. pdf reprint
Kourkine IV, Hestekin CN, Buchholz BA, Barron AE, "High-throughput, high-sensitivity genetic mutation detection by tandem single-strand conformation polymorphism (SSCP) / heteroduplex analysis (HA) capillary array electrophoresis (CAE)," Anal. Chem. 2002, 74: 2565-2572. pdf reprint
Vreeland WN, Slater GW, Barron AE, "Profiling solid-phase synthesis products by free-solution conjugate capillary electrophoresis," Bioconjugate Chem. 2002, 13: 663-670. pdf reprint
Barbier V, Buchholz BA, Barron AE, Viovy J-L, "Comb-like co-polymers as self-coating low-viscosity and high-resolution matrices for DNA sequencing," Electrophoresis 2002, 23: 1441-1449. pdf reprint
Albarghouthi MN, Buchholz BA, Huiberts PJ, Stein TM, Barron AE, "Poly-N-hydroxyethyl acrylamide (polyDuramide): A novel hydrophilic, self-coating polymer matrix for DNA sequencing by capillary electrophoresis," Electrophoresis 2002, 23: 1429-1440. pdf reprint
He H, Buchholz BA, Kotler L, Miller AW, Barron AE, Karger BL, "DNA sequencing with hydrophilic and hydrophobic polymers at elevated column temperatures," Electrophoresis 2002, 23: 1421-1428. pdf reprint
Buchholz BA, Shi W, Barron AE, "Microchannel DNA sequencing matrices with switchable viscosities," Electrophoresis 2002, 23: 1398-1409. (review article) pdf reprint
Kourkine IV, Hestekin CN, Barron AE, "Technical challenges in applying Capillary Electrophoresis (CE) - Single-Strand Conformation Polymorphism (SSCP) / heterduplex analysis (HA) capillary array electrophoresis (CAE)," Electrophoresis 2002, 23: 1375-1385. (review article) pdf reprint
Kourkine IV, Hestekin CN, Magnusdottir SO, Barron AE, "Optimized sample preparation methods for tandem capillary electrophoresis single-strand conformation polymorphism / heteroduplex analysis (CE-SSCP/HA)," Biotechniques 2002, 33: 318-325. pdf reprint
Vreeland WN, Barron AE, "Functional materials for microscale genomic and proteomic analyses," Current Opinion in Biotechnology 2002, 13: 287-294. (review article) pdf reprint
Buchholz BA and Barron AE, "Multi-angle laser light scattering characterization of high molar mass, linear polyacrylamides with application as DNA sequencing matrices for microchannel electrophoresis," Electrophoresis 2001; 22: 4118-4128. pdf reprint
Vreeland WN, Desruisseaux C, Karger AE, Drouin G, Slater GW, Barron AE, "Molar mass profiling of synthetic polymers by free-solution capillary electrophoresis of DNA-polymer conjugates," Anal. Chem. 2001, 73: 1795-1803. pdf reprint
Albarghouthi MN, Buchholz BA, Doherty EAS, Bogdan FM, Zhou H, Barron AE, "Impact of polymer hydrophobicity on the properties and performance of DNA sequencing matrices for capillary electrophoresis," Electrophoresis 2001, 22: 737-747. pdf reprint
Buchholz BA, Doherty EAS, Albarghouthi MN, Bogdan FM, Zahn JM, Barron AE, "Microchannel DNA sequencing matrices with a thermally controlled 'viscosity switch,'" Anal. Chem. 2001, 73: 157-164. pdf reprint
McCormick L, Slater GW, Karger AE, Vreeland WN, Barron AE, Desruisseaux C, Drouin G, "CE separation of uncharged polymers using polyelectrolyte engines: A theoretical model," J. Chrom. A 2001; 924: 43-52. pdf reprint
Albarghouthi MN, Barron AE, "Polymeric matrices for DNA sequencing by capillary electrophoresis," Electrophoresis 2000, 21: 4096-4111. (review article) pdf reprint
Zhou H, Miller AW, Sosic Z, Buchholz B, Barron AE, Kotler L, Karger BL, "DNA sequencing up to 1300 bases in two hours by capillary electrophoresis with mixed replaceable linear polyacrylamide solutions," Anal. Chem. 2000, 72: 1045-1052. pdf reprint
A.E. Barron and C. Heller, "DNA separations by capillary electrophoresis in polymer solutions: comparison of experiment with theory," Analysis of Nucleic Acids by Capillary Electrophoresis , C. Heller, Ed. (1997) Vieweg Press, Amsterdam, The Netherlands. (book chapter) pdf reprint
Bünz AP, Barron AE, Prausnitz JM, Blanch HW, "Capillary electrophoretic separation of DNA restriction fragments in mixtures of low- and high-molecular-weight hydroxyethyl cellulose," Ind. Eng. Chem. Res. 1996, 35: 2900-2908. pdf reprint
Sassi AP, Barron AE, Alonso-Amigo G, Hion D, Yu J, Soane DS, Hooper HH, "Electrophoresis of DNA in novel thermo-reversible matrices," Electrophoresis 1996, 17: 1460-1469. pdf reprint
Vreeland WN, Barron AE, "Free-solution capillary electrophoresis of polypeptoid-oligonucleotide conjugates." Polymer Preprints, 2000, 41: 1018-1019. (extended abstract) pdf reprint
Barron AE, Sunada WM, Blanch HW, "Effects of polymer properties on the separation of DNA fragments by capillary electrophoresis in uncrosslinked polymer solutions," Electrophoresis 1996, 17: 744-757. pdf reprint
Barron AE, Sunada WM, Blanch HW, "Capillary electrophoresis of DNA in uncrosslinked polymer solutions: Evidence for a new mechanism of DNA separation," Biotechnology & Bioengineering 1996, 52: 259-270. pdf reprint
Barron AE, Sunada WM, Blanch HW, "The use of coated and uncoated capillaries for the electrophoretic separation of DNA in dilute polymer solutions," Electrophoresis 1995, 16: 64-74. pdf reprint
Barron AE, Blanch HW, Soane DS, "A transient entanglement coupling mechanism for DNA separation by capillary electrophoresis in ultra-dilute polymer solutions," Electrophoresis 1994, 15: 597-615. pdf reprint
Barron AE, Soane DS, Blanch HW, "Capillary electrophoresis of DNA in uncrosslinked polymer solutions," J. Chromatogr. 1993, 652: 3-16. pdf reprint
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