Research articles

(from latest to oldest, of approximately 200)

Porpiglia E, Samusik N, Van Ho AT, Cosgrove BD, Mai T, Davis KL, Jager A, Nolan GP, Bendall SC, Fantl WJ, Blau HM (2017) High-resolution myogenic lineage mapping by single-cell mass cytometry. Nature Cell Biology 19(5):558-567. doi:10.1038/ncb3507. Epub 2017 Apr 17. PubMed PMID: 28414312. (PDF)

Theodoris CV, Mourkioti F, Huang Y, Ranade SS, Liu L, Blau HM, Srivastava D (2017) Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency. Journal of Clinical Investigation 127(5):1683-1688. doi:10.1172/JCI90338. Epub 2017 Mar 27. PubMed PMID: 28346225; PubMed Central PMCID: PMC5409071. (PDF)

Wong WT, Matrone G, Tian X, Tomoiaga SA, Au KF, Meng S, Yamazoe S, Sieveking D, Chen K, Burns DM, Chen JK, Blau HM, Cooke JP (2017) Discovery of novel determinants of endothelial lineage using chimeric heterokaryons. Elife 6. pii:e23588. doi: 10.7554/Elife23588. PubMed PMID: 28323620; PubMed Central PMCID: PMC5391207. (PDF)

Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, Thrun S (2017) Dermatologist-level classification of skin cancer with deep neural networks. Nature 542(7639):115-118. doi: 10.1038/nature21056. PMID: 28117445. (PDF)

Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM (2016) Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy. PNAS 113(46):13120-13125. PMID: 27799523; PubMed Central PMCID: PMC5135315. (PDF)

Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC (2016) Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nature Medicine 22(5):547-56. doi: 10.1038/nm.4087. Epub 2016 Apr 18. PubMed PMID: 27089514; PubMed Central PMCID: PMC5086256. (PDF)

Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y (2015) Stem Cells and Aging: What's Next? Nature Medicine 16(6):578-81. PubMed PMID: 26247067. (PDF)

Wang H, Lööf S, Borg P, Nader GA, Blau HM, Simon A (2015) Turning terminally differentiated skeletal muscle cells into regenerative progenitors. Nature Communications 6:7916. doi: 10.1038/ncomms8916. PubMed PMID: 26243583; PubMed Central PMCID: PMC4765497. (PDF)

Raval A, Behbehani GK, Nguyen le XT, Thomas D, Kusler B, Garbuzov A, Ramunas J, Holbrook C, Park CY, Blau H, Nolan GP, Artandi SE, Mitchell BS (2015) Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice. PLoS One 10(7). PMID: 26133370 PMCID: PMC4489842. (PDF)

Blau HM, Cosgrove BD, Ho AT (2015) The central role of muscle stem cells in regenerative failure with aging. Nature Medicine 21(8):854-62. (PDF)

Magnusson, K.E.G., Jaldén, J., Gilbert, P.M. and Blau,H.M. (2015) Global linking of cell tracks using the Viterbi algorithm. IEEE Trans Med Imaging 34(4):911-929. (PDF)

Kim, P.J., Mahmoudi, M., Ge, X., Matsuura, Y., Toma, I., Metzler, S., Kooreman, N.G., Ramunas, J., Holbrook, C., McConnell, M.V., Blau, H., Harnish, P., Rulifson, E. and Yang, P.C. (2015) Direct evaluation of myocardial viability and stem cell engraftment demonstrates salvage of the injured myocardium. Circulation Research 116(7):e40-50. DOI: 10.1161/CIRCRESAHA. NIHMSID 661955. (PDF)

Ramunas, J., Yakubov, E., Brady, J. J., Corbel, S. Y., Holbrook, C., Brandt, M, Stein, J., Santiago, J.G., Cooke, J.P. and Blau, H.M. (2015) Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells. The FASEB Journal 29(5):1930-1939 PMC4415018. (PDF)

Tamaki, S., Nye, C., Loorach, E., Scharp, D., Blau, H.M., Whiteley, P.E. and Pomerantz, J.H. (2014) Simultaneous silencing of multiple RB and p53 pathway members induces cell cycle reentry in intact human pancreatic islets. BMC Biotechnology 14(86) (PDF)

Blau, H.M. (2014) Sir John Gurdon: father of nuclear reprogramming. Differentiation 88:10-12. Special issue in honor of Sir John Gurdon. NIHMSID: 666483. (PDF)

Chenouard, N., Smal, I., de Chaumont, F., Maška, M., Sbalzarini, I.F., Gong, Y., Cardinale, J., Carthel, C., Coraluppi, S. Winter, M., Cohen, A.R., Godinez, W.J., Rohr, K., Kalaidzidis, Y. Liang, L., Duncan, J., Shen, H., Xu, Y., Magnusson, K.E.G., Jaldén, J., Blau, H.M., Paul-Gilloteaux, P., Roudot, P., Kervrann, C., Waharte, F., Tinevez, J-Y., Shorte, S.L., Willemse, J., Celler, K., van Wezel, G.P., Dan, H-W., Tsai, Y-S., Ortiz de Solórzano, E., Olivo-Marin, J-C., and Meijering, E. (2014) Objective comparison of particle tracking methods. Nature Methods 11(3):281-289. DOI:10.1038/nmeth.2808. (PDF)

Maška, M., Ulman, V., Svoboda, D., Matula P., Ederra, C., Urbiola, A., España, T., Venkatesan, S., Balak, D.M.W., Karas, P., Bolcková, T., Štreitová, M., Carthel, C., Coraluppi, S., Harder, N., Rohr, K., Magnusson, K.E.G., Jaldén, J., Blau, H. M., Dzyubachyk, O., Křížek, P., Hagen, G.M., Pastor-Escuredo, D., Jimenez-Carretero, D., Ledesma-Carbayo, M.J., Muñoz-Barrutia, Meijering, E., Kozubek, M. and Ortiz-de-Solorzano, C. (2014) A benchmark for comparison of cell tracking algorithms. Bioinformatics 30(11):1609-17. (PDF)

Cosgrove, B.D., Gilbert, P.M., Porpiglia, E., Mourkioti, F., Lee, S.P., Corbel, S.Y., Llewellyn, M.E., Delp, S.L. and Blau, H.M. (2014). Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nature Medicine 20(3):255-264. (PDF)

Chu, J., Haynes, R.D., Corbel, S.Y., Li, P., González-González, E., Burg, J.S., Ataie, N.J., Cranfill, P.H., Baird, M.A., Davidson, M.W., Ng, H.L., Garcia, K.C., Contag, C.H., Shen, K., Blau, H.M. and Lin, M.Z. (2014) Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein. Nature Methods 11(5):572-578. (PDF)

Tremblay, J.P., Xiao, X., Aartsma-Rus, A., Barbas, C., Blau, H.M., Bogdanove, A.J., Boycott, K., Braun, S., Breakefield, X.O., Bueren, J.A., Buschmann, M., Byrne, B.J., Calos, M., Cathomen, T., Chamberlain, J., Chuah, M., Cornetta, K., Davies, K.E., Dickson, J.G., Duchateau, P., Flotte, T.R., Gaudet, D., Gersbach, C.A., Gilbert, R., Glorioso, J., Herzog, R.W., High, K.A., Huang, W., Huard, J., Joung, J.K., Liu, D., Liu, D., Lochmüller, H., Lustig, L., Martens, J., Massie, B., Mavilio, F., Mendell, J.R., Nathwani, A., Ponder, K., Porteus, M., Puymirat, J., Samulski, J., Takeda, S., Thrasher, A., Vanden Driessche, T., Wei, Y., Wilson, J.M., Wilton, S.D., Wolfe, J.H. and Gao, G. (2013) Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases Molecular Therapy 21(2):266-8. PMCID: PMC3594019.

Brady JJ, Li M, Suthram S, Jiang H, Wong WH, Blau HM. (2013) Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq Nature Cell Biology doi:10.1038/ncb2835. (PDF)

Mourkioti F, Kustan J, Kraft P, Day JW, Zhao MM, Kost-Alimova M, Protopopov A, Depinho RA, Bernstein D, Meeker AK, Blau HM. (2013) Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy Nature Cell Biology 15, 895-904. (PDF)

Pomerantz J.H. and Blau, H.M. (2013) Tumor suppressors: enhancers or suppressors of regeneration? Development 140, 2502-2512. (PDF)

Bhutani, N., Decker, M.N., Brady, J.J., Bussat, R.T., Burns, D.M., Corbel, S.Y. and Blau, H.M. (2012) Critical role for AID in initiation of reprogramming to induced pluripotency The FASEB Journal 27, 1107-1113. (PDF)

Sengupta, D., Gilbert, P.M., Johnson, K.J., Blau, H.M. and Heilshorn, S. C. (2012) Protein-engineered biomaterials to generate human skeletal muscle mimics Adv. Healthcare Mat. 1(6):785-789. DOI: 10.1002/adhm.201200195. (PDF)

Blau, H.M. (2012) Redefining differentiation: reshaping our ends. Nature Cell Biology 14(6):558 Invited Turning Point Commentary. (PDF)

Banfi, A., von Degenfeld, G., Gianni-Barrera, R., Reginato, S., Merchant, M.J., McDonald, D.M. and Blau, H.M. (2012) Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB The FASEB Journal 26, 2486-2497. (PDF)

Gilbert, P.M., Corbel, S., Doyonnas, R., Havenstrite, K., Magnusson, K. and Blau, H.M. (2012) A single cell bioengineering approach to elucidate mechanisms of adult stem cell self-renewal. Integrative Biology 4:360-367. (PDF)

Lee, V.Y., Havenstrite, K., Tjio, M., McNeil, Blau, H.M., Miller, R.D. and Sly, J. (2011) Nanogel star polymer architectures: a nanoparticle platform for modular programmable macromolecular self-assembly, intercellular transport and dual-mode cargo delivery. Advanced Materials 23(39):4509-4515. PMCID: PMC3324179. (PDF)

Gibbs, K.D., Jr., Gilbert, P.M., Sachs, K., Shao, R., Blau, H.M., Weissman, I.L., Nolan, G.P. and Majeti, R. (2011) Single-cell phosphor-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood 117:4226-4233. PMCID: PMC3087474. (PDF)

Vleck, S.E., Oliver, S.L., Brady, J.J., Blau, H.M., Rajamani, J., Sommer, M.H. and Arvin, A.M. (2011) Structure-function analysis of varicella-zoster virus glycoprotein H identifies domain-specific roles for fusion and skin tropism. PNAS 108(45):18412-18417. (PDF)

Arnold, C.P., Tan, R., Zhou, B., Yue, S-B., Schaffert, S., Biggs, J.R., Doyonnas, R., Lo, M-C., Perry, J.M., Renault, V.M., Sacco, A., Somervaille, T., Viatour, P., Brunet, A., Cleary, M.L., Li, L., Sage, J., Zhang, D-E., Blau, H.M., Chen, C. and Chen, C-Z. (2011) MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Research 21:798-810. PMCID: PMC3083097.(PDF)

Bhutani, N., Burns, D.M. and Blau, H.M. (2011) DNA demethylation dynamics. Cell 146:866-872. Cited in Faculty of 1000 (http://f1000.com/13386964). PMCID: PMC3236603.(PDF)

Gilbert, P.M. and Blau, H.M. (2011) Engineering a stem cell house into a home. Stem Cell Research & Therapy 2(1):3. PMCID: PMC3092143.(PDF)

Blau, H.M. and Pomerantz, J.H. (2011) Re“evolutionary” regenerative medicine. JAMA 305(1):87-88. PMCID: PMC3105469.(PDF)

Sacco, A., Mourkioti, F., Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp, S., Pomerantz, J. H., Artandi, S.E. and Blau, H.M. (2010) Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. Cell 143(7):1059-71. Cited in Faculty of 1000 (http://f1000.com/7577958). PMCID: PMC3025608. (PDF)

Park, C.Y., Pierce, S.A., von Drehle, M., Ivey, K.N., Morgan, J., Blau, H.M. and Srivastava, D. (2010) skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. PNAS 107(48):20750-20755. PNAS2010.pdf" target="_blank">(PDF)

Gilbert, P.M., Havenstrite, K.L., Magnusson, K.E.G., Sacco, A., Leonardi, N.A., Kraft, P., Nguyen, N.K., Thrun, S., Lutolf, M.P. and Blau, H.M. (2010) Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science 329(5995):1078-1081. Cited in Faculty of 1000 (http://f1000medicine.com/article/id/4942962). PMCID: PMC2929271.(PDF)

Pajcini, K.V., Corbel, S.C., Sage, J., Pomerantz, J.H. and Blau, H.M. (2010) Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell 7(2):198-213. Cited in Faculty of 1000 (http://f1000.com/13386962). PMCID: 2919350.(PDF)

Yamanaka, S. and Blau, H.M. (2010) Nuclear reprogramming to a pluripotent state by three approaches. Nature 465(7299):704-712. Cited in Faculty of 1000 (http://f1000.com/13386966). PMCID: PMC2901154.(PDF)

Koshy, A.A., Fouts, A.E., Lodoen, M.B., Alkan, O., Blau, H.M. and Boothroyd, J.C. (2010) Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions. Nature Methods 7(4):307-309. PMCID: PMC2850821.(PDF)

Bhutani, N., Brady, J.J., Damian, M., Sacco, A., Corbel, S.Y. and Blau, H.M. (2010) Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 463(7284):1042-1047. Cited in Faculty of 1000 (http://f1000biology.com/article/ id/2407956). (PDF)

Lutolf, M.P., Gilbert, P.M. and Blau, H.M. (2009) Designing materials to direct stem-cell fate. Nature 462(7272):433-441. (PDF)

Cosgrove, B.D., Sacco, A., Gilbert, P.M. and Blau, H.M. (2009) A home away from home: Challenges and opportunities in engineering in vitro muscle satellite cell niches. Differentiation 78(2-3):185-194. (PDF)

Lutolf, M.P. and Blau, H.M. (2009) Artificial stem cell niches. Advanced Materials 21:3255-3268. (PDF)

Palermo, A., Doyonnas, R., Bhutani, N., Pomerantz, J., Alkan, O. and Blau, H.M. (2009) Nuclear reprogramming in heterokaryons is rapid, extensive and bidirectional. The FASEB Journal 23:1431-1440. PMCID: PMC2669427.(PDF)

Pomerantz, J.H., Mukherjee, S., Palermo, A.T. and Blau, H.M. (2009) Reprogramming to a muscle fate by fusion recapitulates differentiation. J. Cell Science 122(7):1045-1053. PMCID: PMC2720934.(PDF)

Lutolf, M.P., Doyonnas, R., Havenstrite, K., Koleckar, K. and Blau, H.M. (2009) Perturbation of single hematopoietic stem cell fates in artificial niches. Integrative Biology 1:59-69 (Cover of 1st edition of iBiology, new Journal of the Royal Society, UK). (PDF)

Sacco, A., Doyonnas, R., Kraft, P., Vitorovic, S. and Blau H.M. (2008) Self-renewal and expansion of single transplanted muscle stem cells. Nature 456:502-506. Cited in Faculty of 1000 (http://www.f1000medicine.com/article/id/1124026). PMCID: PMC2919355.(PDF)

Blau, H.M. (2008) Clinical implications for basic research: Cell therapies for Muscular Dystrophy (invited review). N. Engl. J. Med. 359(13):1410-1412.(PDF)

Li, X., Tjwa, M., Van Hove, I., Enholm, B., Neven, E., Paavonen, K., Jeltsch, M., Juan, T.D., Sievers, R.D., Chorianopoulos, E., Wada, H., Vanwildemeersch, M., Noel, A., Foidart, J-M., Springer, M.T., von Degenfeld, G., Dewerchin, M., Blau, H.M., et al. (2008) Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Bio. 28(9):1614-1620. PMCID: PMC2753879.(PDF)

Johansson, C.B., Youssef, S., Koleckar, K., Holbrook, C., Doyonnas, R., Corbel, S.Y., Steinman, L., Rossi, F.M.V. and Blau, H.M. (2008) Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation. Nature Cell Biology 10(5): 575-583.(PDF)

Pajcini, K.V., Pomerantz, J.H., Alkan, O., Doyonnas, R. and Blau, H.M. (2008) Myoblasts and macrophages share molecular components that contribute to cell-cell fusion. Journal of Cell Biology 180:1005-1019. Cited in Faculty of 1000 (http://www.f1000 biology.com/article/id/1108067). (PDF)

Streetz, K.L., Doyonnas, R., Grimm, D., Jenkins, D.D., Fuess, S., Perryman, S., Lin, J., Trautwein, C., Shizuru, J., Blau, H., Sylvester, K.G., and Kay, M.A. (2008) Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells. Hepatology 47(2):706-718.

Hammer, M.M., Wehrman, T.S., Blau, H.M. (2007) Novel enzyme complementation-based assays for G protein-coupled receptor signaling. The FASEB Journal 21:3827-3834.

von Degenfeld, G., Wehrman, T.S., Hammer, M. and Blau, H.M. (2007) A universal technology for monitoring GPCR activation in vitro and non-invasively in live animals. The FASEB Journal 21:3819-3826. Cited in the Faculty of 1000 (http://www.f1000biology.com/ article/id/1093872).(PDF)

Blum, G., von Degenfeld, G., Merchant, M.J., Blau, H.M., Bogyo, M. (2007) Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nature Chemical Biology 3(10):668-77. Cited in the Faculty of 1000 (http://www.f1000biology.com/article/id/1090876).(PDF)

Keshet, G.I., Tolwani, R.J., Trejo, A., Kraft, P., Doyonnas, R., Clayberger, C., Weimann, J.M., and Blau, H.M. (2007) Increased host neuronal survival and motor function in BMT Parkinsonian mice: Involvement of immunosupression. Journal of Comparative Neurology 504:690-701.(PDF)

Wan, D.C., Pomerantz, J.H., Brunet, L.J., Kim, J.-B., Chou, Y.-F., Wu, B.M., Harland, R., Blau, H.M. and Longaker, M.T. (2007) Noggin suppression enhances in vitro osteogensis and accelerates in vivo bone formation. Journal of Biological Chemistry 282:26450-26459 (Epub July 2, doi10.1074/jbc.M703282200).(PDF)

Zhang, F., Pomerantz, J.H., Sen, G., Palermo, A.T., and Blau, H.M. (2007) Post-mitotic somatic cells direct the reprogramming of DNA methylation in ectopic nuclei. PNAS 104(11):4395-4400. (PDF)

Kutschka, I., Chen, I.Y., Kofidis, T., von Degenfeld, G., Sheikh, A.Y., Hendry, S.L., Hoyt, G., Pearl, J., Blau, H.M., Gambhir, S.S. and Robbins, R.C. (2007) In vivo optical bioluminescence imaging of collagen-supported cardiac cell graphs. Journal of Heart and Lung Transplant 26:3:273-280.(PDF)

Springer, M.L., Banfi, A., Ye, J., von Degenfeld, G., Kraft, P.E., Saini, S.A., Kapasi, N.K., and Blau, H.M. (2007) Localization of vascular response to VEGF is not dependent on heparin binding. The FASEB Journal 21 (Express article doi:10.1096/fj.06-7700com:1-12).(PDF)

Wehrman, T., He, X., Raab, B., Dukipatti, A., Blau, H. and Garcia, K.C. (2007) Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron 53:25-38. Cited in Faculty of 1000 (http://www. f1000biology.com/article/id/1058949).(PDF)

Wehrman, T.S., Raab, W.J., Casipit, C.L., Doyonnas, R., Pomerantz, J.H. and Blau, H.M. (2006) A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions. PNAS, 103(50):19063-19068. PMCID: PMC1748177.(PDF)

von Degenfeld, G., Banfi, A., Springer, M.L., Wagner, R.A., Jacobi, J., Ozawa, C.R., Merchant, M.J., Cooke, J.P. and Blau, H.M. (2006) Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia. The FASEB Journal, 20(14):2657-9.(PDF)

Kutschka, I., Kofidis, T., Chen, I.Y., von Degenfeld, G., Zwierzchoniewska, M., Hoyt, G., Arai, T., Lebl, D.R., Hendry, S.L., Sheikh, A.Y., Cooke, D.T., Connolly, A., Blau, H.M., Gambhir, S.S. and Robbins R.C. (2006) Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts. Circulation 114 (1 Suppl):1174-1180.(PDF)

Kutschka, I., Chen, I.Y., Kofidis, T., Arai, T., von Degenfeld, G., Sheikh, A.Y., Hendry, S.L., Pearl, J., Hoyt, G., Sista, R., Yang, P.C., Blau, H.M., Gambhir, S.S. and Robbins R.C. (2006) Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to the improvement of ischemic rat hearts. Circulation 114(1 Suppl):1167-1173.(PDF)

Sen, G.L. and Blau, H.M. (2006) A brief history of RNAi: the silence of the genes. The FASEB Journal 20(9):1293-1299.(PDF)

Wehrman, T.S., von Degenfeld, G., Krutzik, P. O., Nolan, G.P. and Blau, H.M. (2006) Luminescent imaging of b-galactosidase activity in living subjects using sequential reporter-enzyme luminescence. Nature Methods 3(4):295-301.(PDF)

Sacco, A., Doyonnas, R., LaBarge, M.A., Hammer, M.M., Kraft, P. and Blau, H.M. (2005) IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors. Journal of Cell Biology 171(3):483-492. (PDF)

Brazelton, T.R. and Blau, H.M. (2005) Optimizing techniques for tracking transplanted stem cells in vivo. Stem Cells 23(9):1251-1265.(PDF)

Sen, G.L., Wehrman, T.S. and Blau, H.M. (2005) mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage. Differentiation 73:287-293.(PDF)

Wehrman, T.S., Casipit, C.L., Gewertz, N.M. and Blau, H.M. (2005) Enzymatic detection of protein translocation. Nature Methods 2(7):521-527. Cited by Faculty of 1000 (http://www.f1000biology.com/article/id/1029933).(PDF)

Banfi, A., von Degenfeld, G. and Blau, H.M. (2005) Critical role of microenvironmental factors in angiogenesis. Curr. Atheroscler. Rep. 7(3):227-234.(PDF)

Sen, G. and Blau, H.M. (2005) Argonaute 2/RISC resides in cytoplasmic bodies, sites of mammalian mRNA decay. Nature Cell Biology 7(6):633-636. Cited by Faculty of 1000 (http://www.f1000biology.com/article/id/1026649).(PDF)

Jacobi, J., Sydow K., von Degenfeld, G., Zhang, Y., Hayan Dayoub, H., Bingyin Wang B., Patterson, A. J., Kimoto, M., Blau, H.M., and Cooke, J.P. (2004) Overexpression of dimethylarginine dimethylaminohydrolase (DDAH) reduces tissue ADMA levels and enhances angiogenesis. Circulation 111(11):1421-1438.(PDF)

Palermo, A.T., LaBarge, M.A., Doyonnas, R., Pomerantz, J. and Blau, H.M. (2005) Bone marrow contribution to skeletal muscle: a physiological response to stress. Developmental Biology 279:336-344.(PDF)

Doyonnas, R., LaBarge, M.A., Sacco, A., Charlton, C. and Blau, H.M. (2004) Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. PNAS 101(37):13507-13512. (PDF)

Pomerantz, J. and Blau, H.M. (2004) Nuclear reprogramming: A key to stem cell function in regenerative medicine. Nature Cell Biology 6:810-816.(PDF)

Ozawa, C.R., Banfi, A., Glazer, N., Thurston, G., Springer, M.L., Kraft, P.E., McDonald, D.M. and Blau, H.M. (2004) Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. Journal of Clinical Investigation 113(4):516-527. (PDF)

Sen, G., Wehrman, T.S., Myers, J. and Blau, H.M. (2004) Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nature Genetics 36(2):183-189. Cited by Faculty of 1000 (http://www.f1000biology.com/article/id/1017167).(PDF)

Jacobi, J., Tam, B.Y.Y., Sundram, U., von Degenfeld, G., Blau, H.M. Kuo, C. J. and Cooke, J.P. (2004) Discordant effects of a soluble VEGF receptor on wound healing and angiogenesis. Gene Therapy 11:302-309.(PDF)

Corbel, S.Y., Lee, A., Yi, L., Duenas, J., Brazelton, T.R., Blau, H.M. and Rossi, F.M.V. (2003) Contribution of hematopoietic stem cells to skeletal muscle. Nature Medicine 9(12):1528-1532.(PDF)

Weimann, J.M., Johansson, C.B., Trejo, A. and Blau, H.M. (2003) Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons in adult brain after BMT. Nature Cell Biology 5(11):959-966.(PDF)

von Degenfeld, G., Banfi, A., Springer, M.L. and Blau, H.M. (2003) Myoblast-mediated gene transfer for therapeutic angiogenesis and arteriogenesis. Brit. J. Pharm. 140:620-626. (PDF)

Brazelton, T.R., Nystrom, M. and Blau, H.M. (2003) Significant differences among skeletal muscles in the incorporation of bone marrow derived cells. Developmental Biology 262:64-74.(PDF)

Springer, M.L., Ozawa, C.R., Banfi, A., Kraft, P.E., Ip, T.K., Brazelton, T.R. and Blau, H.M. (2003) Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle. Molecular Therapy 7:441-9.(PDF)

Weimann, J.M., Charlton, C.A., Brazelton, T.R., Hackman, R.C. and Blau, H.M. (2003) Contribution of transplanted bone marrow cells to purkinje neurons in human adult brains. PNAS 100:2088-2093. PMCID: PMC149963.(PDF)

LaBarge, M.A. and Blau, H.M. (2002) Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury. Cell 111:589-601. (PDF)

Blau, H.M., Brazelton, T., Keshet, G. and Rossi, F. (2002) Something in the eye of the beholder. Science 298:361-362. (invited)

Blau, H.M. (2002) A twist of fate. Nature 419:437. (invited) (PDF)

Munz, B., Hildt, E., Springer, M.L. and Blau, H.M. (2002) RIP2, a checkpoint in myogenic differentiation. Molecular and Cellular Biology 22:5879-5886. Cited by Faculty of 1000 (http://www.f1000biology.com/article/id/1009515).(PDF)

Koransky, M.L., Robbins, R.C. and Blau, H.M. (2002) VEGF gene delivery for treatment of ischemic cardiovascular disease. Trends in Cardiovascular Medicine 12:108-114.(PDF)

Springer, M.L., Ozawa, C.R. and Blau, H.M. (2002) Transient production of a-smooth muscle actin by skeletal myoblasts during differentiation in culture and following intramuscular implantation. Cell Motility and the Cytoskeleton 51:177-186.(PDF)

Wehrman, T., Kleaveland, B.M., Her, J-H., Balint, R. and Blau, H.M. (2002) Protein-protein interactions monitored in mammalian cells via complementation of b-lactamase enzyme fragments. PNAS 99:3469-3474. Cited by Faculty of 1000 (http://www.f1000biology.com/article/id/1005525).(PDF)

Blau, H.M., Brazelton, T.R. and Weimann, J.M. (2001) The evolving concept of a stem cell: Entity or function? Cell 105:829-841. (invited)(PDF)

Springer, M.L., Brazelton, T.R. and Blau, H.M. (2001) Not the usual suspects: the unexpected sources of tissue regeneration. Journal of Clinical Investigation 107:1355-1356. PMCID: PMC209330.(PDF)

Blanco-Bose, W.E. and Blau, H.M. (2001) Laminin-induced change in conformation of pre-existing a7b1 integrin signals secondary myofiber formation. Developmental Biology 233:148-160.(PDF)

Blanco-Bose, W.E., Yao, C.-C., Kramer, R.H. and Blau, H.M. (2001) Purification of mouse primary myoblasts based on a7 integrin expression. Experimental Cell Research 265:212-220.(PDF)

Blau, H.M. and Banfi, A. (2001) The well-tempered vessel. Nature Medicine 7:532-534.(PDF)

Brazelton, T.R., Rossi, F. M.V., Keshet, G.I. and Blau, H.M. (2000) From marrow to brain: Expression of neuronal phenotypes in adult mice. Science 290:1775-1779.(PDF)

Rossi, F.M.V., Kringstein, A.M, Spicher, A., Guicherit, O.M. and Blau, H.M. (2000) Transcriptional control: Rheostat converted to on/off switch. Molecular Cell 6:723-728.(PDF)

Lee, R.J., Springer, M.L., Blanco-Bose, W.E., Shaw, R., Ursell, P.C. and Blau, H.M. (2000) VEGF gene delivery to myocardium: Deleterious effects of unregulated expression. Circulation 102:898-901.(PDF)

Springer, M.L., Hortelano, G., Bouley, D., Wong, J., Kraft, P.E. and Blau, H.M. (2000) Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor. J. Gene Med. 2:279-288.(PDF)

Charlton, C.A., Mohler, W.A. and Blau, H.M. (2000) Neural cell adhesion molecule (NCAM) and myoblast fusion. Developmental Biology 221:112-119.(PDF)

Blakely, B.T., Rossi, F. M.V., Tillotson, B., Palmer, M., Estellés, A. and Blau, H.M. (2000) Epidermal growth factor receptor dimerization monitored in live cells. Nature Biotechnology 18:218-222.(PDF)

Rossi, F.M.V., Blakely, B.T. and Blau, H.M. (2000) Interaction blues: Protein interactions monitored in live mammalian cells by b-gal complementation. Trends in Cell Biology 10:119-122. (PDF)

Springer, M.L., Ip, T.K. and Blau, H.M. (2000) Angiogenesis monitored by perfusion with a space-filling microbead suspension. Molecular Therapy 1:82-87.(PDF)

Abendroth, A., Slobedman, B., Springer, M.L, Blau, H.M. and Arvin, A.M. (1999) Analysis of immune responses to varicella zoster viral proteins induced by DNA vaccination. Antiviral Research 44:179-192.(PDF)

Estellés, A., Charlton, C.A. and Blau, H.M. (1999) The phosphoprotein protein PEA15 inhibits Fas- but increases TNFR-1-mediated caspase-8 activity and apoptosis. Developmental Biology 216:16-28.(PDF)

Springer, M.L., Kraft, P.E. and Blau, H.M. (1999) Inhibition of solid tumor growth by Fas ligand-expressing myoblasts. Som. Cell Mol. Genet. 24:281-289.(PDF)

Blau, H.B., and Rossi, F.M. (1999) Tet B or not tet B: Advances in tetracycline-inducible gene expression. PNAS 96:797-799.(PDF)

Springer, M.L., Chen, A. S., Kraft, P. E., Bednarski, M. and Blau, H. M. (1998) VEGF gene delivery to muscle: Potential role for vasculogenesis in adults. Molecular Cell 2:549-558.(PDF)

Spicher, A., Guicherit, O.M., Duret, L., Aslanian, A., Sanjines, E.M., Denko, N.C., Giaccia, A.J. and Blau, H., (1998) Highly conserved RNA sequences that are sensors of environmental stress. Molecular and Cellular Biology 18:7371-7382.(PDF)

Fridman, J. S., Rehemtulla, A., Hofmann, A., Blau, H.M. and Maybaum, J. (1998) Expression of Bcl-XS alters cytokinetics and decreases clonogenic survival in K12 rat colon carcinoma cells. Oncogene 17:2981-2991.(PDF)

Rossi, F.M.V., Guicherit, O.M., Spicher, A., Kringstein, A.M., Fatyol, K., Blakely, B.T. and Blau, H.M. (1998) Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16. Nature Genetics 20:389-393.(PDF)

Kringstein, A.M., Rossi, F.M.V., Hofmann, A. and Blau, H.M. (1998) Graded transcriptional response to different concentrations of a single transactivator. PNAS 95:13670-13675.(PDF)

Rossi, F.M.V. and Blau H.M. (1998) Recent advances in inducible gene expression systems. Current Opinions in Biotechnology 9:451-456.(PDF)

Hofmann, A. and Blau, H.M. (1997) Death of solid tumor cells induced by Fas ligand-expressing primary myoblasts. Som. Cell Mol. Genet. 23:249-257.(PDF)

Kang, S-M., Hofmann, A., Le, D., Springer, M.L., Stock, P.G. and Blau, H.M. (1997) Immune response and myoblasts that express Fas ligand. Science 278:1322-1324.(PDF)

Springer, M.L. and Blau, H.M. (1997) High-efficiency retroviral infection of primary myoblasts. Som. Cell Mol. Genet. 23:203-209.(PDF)

Rossi, F., Charlton, C.A. and Blau, H.M. (1997) Monitoring protein-protein interactions in intact eukaryotic cells by b-galactosidase complementation. PNAS 94:8405-8410.(PDF)

Gussoni, E., Blau, H.M. and Kunkel, L. (1997) The fate of individual myoblasts following transplantation into muscles of DMD patients. Nature Medicine 3:970-977.(PDF)

Charlton, C.A., Mohler, W.A., Radice, G.L., Hynes, R.O. and Blau, H.M. (1997) Fusion competence of myoblasts rendered homozygous null for N-cadherin in culture. Journal of Cell Biology 138:331-336.(PDF)

Blau, H. and Khavari, P. (1997) Gene therapy: progress, problems, and prospects. Nature Medicine 3:612-613.

Miller, R.G., Sharma, K.R., Pavlath, G.K., Gussoni, E., Mynhier, M., Ye, P., Lanctot, A.M., Greco, C.M., Steinman, L. and Blau, H.M. (1997) Myoblast Implantation in Duchenne Muscular Dystrophy: the San Francisco study. Muscle and Nerve 20:469-478.(PDF)

Mohler, W.A. and Blau, H.M. (1997) Rapid plasmid minipreps in microtiter format from culture to gel. BioTechniques 22:388-390.

Dhawan, J. Rando, T.A., Elson, S.E., Lee, F., Stanley, E.R. and Blau, H.M. (1996) Myoblast-mediated expression of colony stimulating factor-1 (CSF-1) in the cytokine-deficient op/op mouse. Som. Cell Mol. Genet. 22:363-81.(PDF)

Yang, J.T., Rando, T., Mohler, W.A., Rayburn, H., Blau, H.M. and Hynes, R. (1996) Genetic analysis of a4integrin function in the development of mouse skeletal muscle. Journal of Cell Biology 135:829-35.(PDF)

Rohrer, D. and Blau, H.M. (1996) Defective myogenesis in NFB-s mutant associated with a saturable suppression of myf5 activity. Som. Cell Mol. Genet. 22:349-361.(PDF)

Mohler, W.A. and Blau, H.M. (1996) Spectrophotometric quantitation of tissue culture cell number in any medium. BioTechniques 21:260-266.

Mohler, W.A. and Blau, H.M. (1996) Gene expression and cell fusion analyzed by lacZ complementation in mammalian cells. PNAS 93:12423-12427.(PDF)

Gussoni, E., Wang, Y., Fraefel, C., Miller, R.G., Blau, H.M., Geller, A. and Kunkel, L. (1996) A method to codetect introduced genes and their products in gene therapy protocols. Nature Biotechnology 14: 1012-1016.(PDF)

Hofmann, A., Nolan, G.P. and Blau, H.M. (1996) Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette. PNAS 93:5185-5190.(PDF)

Blau, H.M. and Springer, M.L. (1995) Muscle-mediated gene therapy. N. Engl. J. Med. 333:1554-1556.(PDF)

Blau, H.M. and Springer, M.L. (1995) Overview of gene therapy: a novel form of drug delivery. N. Engl. J. Med. 333:1204-1207.(PDF)

Dhawan, J., Rando, T.A. Elson, S.L., Bujard, H. and Blau, H.M. (1995) Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle. Som. Cell Mol. Genet. 21:233-240.(PDF)

Rando, T.A., Pavlath, G.K. and Blau, H.M. (1995) The fate of myoblasts following transplantation into mature muscle. Experimental Cell Research 220:383-389.(PDF)

Pavlath, G.K., Rando, T.A. and Blau, H.M. (1994) Transient immunosuppressive treatment leads to long-term retention of allogeneic myoblasts in hybrid myofibers. Journal of Cell Biology 127:1923-1932.(PDF)

Gussoni, E., Pavlath, G.K., Miller, R.G., Panzara, M.A., Powell, M., Blau, H.M. and Steinman, L. (1994) Specific T-cell receptor gene rearrangments at the site of muscle degeneration in Duchenne muscular dystrophy. Journal of Immunology 153:4798-4805.(PDF)

Cho, M., Hughes, S.M., Karsch-Mizrachi, I., Travis, M., Leinwand, L.A. and Blau, H.M. (1994) Fast myosin heavy chains expressed in secondary mammalian muscle fibers at the time of their inception. Journal of Cell Science 107:2361-2371.(PDF)

Mohler, W.A. and Blau, H.M. (1994) Membrane-bound neomycin phosphotransferase confers drug-resistance in mammalian cells: a marker for high-efficiency targeting of genes encoding secreted and cell-surface proteins. Som. Cell Mol. Genet. 3:153-162.(PDF)

Rando, T.A. and Blau, H.M. (1994) Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy. Journal of Cell Biology 125:1275-1287.(PDF)

Rastinejad, F., Conboy, M., Rando, T.A. and Blau, H.M. (1993) Tumor suppression by RNA from the 3' untranslated region of a-tropomyosin. Cell 75:1107-1117.(PDF)

Blau, H.M. (1993) Muscular Dystrophy. Muscling in on gene therapy. Nature News & Views 364:673-675.(PDF)

Hughes, S.M., Cho, M, Karsch-Mizrachi, I., Travis, M., Silberstein, L., Leinwand, L.A. and Blau, H.M. (1993) Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle. Developmental Biology 158:183-199.(PDF)

Blau, H.M., Dhawan, J. and Pavlath, G.K. (1993) Myoblasts in pattern formation and gene therapy. Trends In Genetics 9:269-274.(PDF)

Cho, M., Webster, S.G. and Blau, H.M. (1993) Evidence for myoblast-extrinsic regulation of slow myosin heavy chain expression during muscle fiber formation in embryonic development. Journal of Cell Biology 121:795-810.(PDF)

Rastinejad, F. and Blau, H.M. (1993) Genetic complementation reveals novel regulatory role for 3' untranslated regions in growth and differentiation. Cell 72:903-917.(PDF)

Blau, H.M. (1992) Differentiation requires continuous active control. Annual Review of Biochemistry 61:1213-1230.(PDF)

Blau, H.M. (1992) How cells know their place. Nature News & Views 358:284-285.(PDF)

Gussoni, E., Pavlath, G.K., Lanctot, A.M., Sharma, K., Miller, R.G., Steinman, L. and Blau, H.M. (1992) Normal dystrophin transcripts detected in DMD patients after myoblast transplantation. Nature 356:435-438.(PDF)

Peterson, C.A., Cho, M., Rastinejad, F.,and Blau, H.M. (1992) ß-Enolase is a marker of human myoblast heterogeneity prior to differentiation. Developmental Biology 151:626-629.(PDF)

Pan, L.C., Margolskee, R.F. and Blau, H.M. (1992) Cloning muscle isoforms of neural cell adhesion molecule using an episomal shuttle vector. Som. Cell Mol. Genet. 18:163-177.

Hughes, S.M. and Blau, H.M. (1992) Muscle fiber pattern is independent of cell lineage in postnatal rodent development. Cell 68:659-671.(PDF)

Dhawan, J., Pan, L.C., Pavlath, G.K., Travis, M.A., Lanctot, A.M. and Blau, H.M. (1991) Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science 254:1509-1512.(PDF)

Blau, H.M. and Baltimore, D. (1991) Differentiation requires continuous regulation. Journal of Cell Biology 112:781-783.(PDF)

Mantegazza, R., Hughes, S.M., Mitchell, D., Travis, M., Blau, H.M, and Steinman, L. (1991) Modulation of MHC class II antigen expression in human myoblasts after treatment with IFN-g. Neurology 41:1128-1132. PMCID: PMC2288865.

Webster, C. and Blau, H.M. (1990) Accelerated age-related decline in replicative lifespan of Duchenne muscular dystrophy myoblasts: Implications for cell and gene therapy. Som. Cell Mol. Genet. 16:557-565.(PDF)

Hughes, S.M. and Blau, H.M. (1990) Cell lineage in vertebrate development. Current Opinion in Cell Biology 2:981-985.

Peterson, C.A., Gordon, H., Hall, Z.W., Paterson, B.M. and Blau, H.M. (1990) Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant. Cell 62:493-502.(PDF)

Hughes, S.M. and Blau, H.M. (1990) Migration of myoblasts across basal lamina during skeletal muscle development. Nature 345:350-353.(PDF)

Condon, K., Silberstein, L., Blau, H.M. and Thompson, W.J. (1990) Differentiation of fiber types in aneural musculature of the prenatal rat hindlimb. Developmental Biology 138:275-295.(PDF)

Condon, K., Silberstein, L., Blau, H.M. and Thompson, W.J. (1990) Development of muscle fiber types in the prenatal rat hindlimb. Developmental Biology 138:256-274.(PDF)

Kaplan, I., Blakely, B.T., Pavlath, G.K., Travis, M. and Blau, H.M. (1990) Steroids induce acetylcholine receptors on cultured human muscle: Implications for myasthenia gravis. PNAS 87:8100-8104.(PDF)

Schäfer, B.W., Blakely, B.T., Darlington, G.J. and Blau, H.M. (1990) Effect of cell history on response to helix-loop-helix family of myogenic regulators. Nature 344:454-458.(PDF)

Karsch-Mizrachi, I., Travis, M., Blau, H.M. and Leinwand, L.A. (1989) Expression and DNA sequence analysis of a human embryonic skeletal muscle myosin heavy chain gene. Nucleic Acids Research 17:6167-6179.(PDF)

Pavlath, G.K., Chiu, C.-P. and Blau, H.M. (1989) In vivo aging of human fibroblasts does not alter nuclear plasticity in heterokaryons. Som. Cell Mol. Genet. 15:191-202.(PDF)

Pavlath, G.K., Rich, K., Webster, S.G. and Blau, H.M. (1989) Localization of muscle gene products in nuclear domains. Nature 337:570-573.(PDF)

Blau, H.M. (1989) How fixed is the differentiated state? Lessons from heterokaryons. Trends in Genetics 5:268-272.(PDF)

Ham, R.G., St. Clair, J.A., Webster, C. and Blau, H.M. (1988) Improved media for normal human muscle satellite cells: Serum-free clonal growth and enhanced growth with low serum. In Vitro Cell Developmental Biology 24:833-844.(PDF)

Miller, S.C., Ito, H., Blau, H.M. and Torti, F.M. (1988) Tumor necrosis factor inhibits human myogenesis in vitro. Molecular and Cellular Biology 8:2295-2301.(PDF)

Blau, H.M. (1988) Hierarchies of regulatory genes may specify mammalian development. Cell 53:673-674.(PDF)

Hardeman, E.C., Minty, A., Benton-Vosman, P., Kedes, L. and Blau, H.M. (1988) In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function. Journal of Cell Biology 106:1027-1034.(PDF)

Webster, C., Silberstein, L., Hays, A.P. and Blau, H.M. (1988) Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy. Cell 52:503-513.(PDF)

Miller, S.C., Pavlath, G.K., Blakely, B.T. and Blau, H.M. (1988) Muscle cell components dictate hepatocyte gene expression and the distribution of the Golgi apparatus in heterokaryons. Genes and Development 2:330-340.(PDF)

Webster, C., Pavlath, G.K., Parks, D.R., Walsh, F.S. and Blau, H.M. (1988) Isolation of human myoblasts with the fluorescence-activated cell sorter. Experimental Cell Research 174:252-265.(PDF)

Soileau, L.C., Silberstein, L., Blau, H.M. and Thompson, W.J. (1987) Reinnervation of muscle fiber types in the newborn rat soleus. Journal of Neuroscience 7:4176-4194.(PDF)

Gunning, P., Hardeman, E., Wade, R., Ponte, P., Bains, W., Blau, H.M. and Kedes, L. (1987) Differential patterns of transcript accumulation during human myogenesis. Molecular and Cellular Biology 7:4100-4114.(PDF)

Hardeman, E., Chiu, C.-P., Minty, A. and Blau, H.M. (1986) The pattern of actin expression in human fibroblast x mouse muscle heterokaryons suggests that human muscle regulatory factors are produced. Cell 47:123-130.(PDF)

Shimizu, M., Webster, C., Morgan, D.O., Blau, H.M. and Roth, R.A. (1986) Insulin and insulin-like growth factor receptors and responses in cultured human muscle cells. American Journal of Physiology 251:E611-E615.(PDF)

Silberstein, L., Webster, S.G., Travis, M. and Blau, H.M. (1986) Developmental progression of myosin gene expression in cultured muscle cells. Cell 46:1075-1081.(PDF)

Costa, E.M., Blau, H.M. and Feldman, D. (1986) 1,25 dihydroxyvitamin D3 receptors and hormonal responses in cloned human skeletal muscle cells. Endocrinology 119:2214-2220.(PDF)

Kaplan, I.D. and Blau, H.M. (1986) Metabolic properties of human acetylcholine receptors can be characterized on cultured human muscle. Experimental Cell Research 166:379-390.(PDF)

Webster, C., Filippi, G., Rinaldi, A., Mastropaolo, C., Tondi, M., Siniscalco, M. and Blau, H.M. (1986) The myoblast defect identified in Duchenne muscular dystrophy is not a primary expression of the DMD mutation: Clonal analysis of myoblasts from double heterozygotes for two X-linked loci: DMD and G6PD. Human Genetics 74:74-80.(PDF)

Minty, A.J., Blau, H.M. and Kedes, L. (1986) Two-level regulation of cardiac actin gene transcription: Muscle-specific modulating factors can accumulate before gene activation. Molecular and Cellular Biology 6:2137-2148.

Pavlath, G.K. and Blau, H.M. (1986) Expression of muscle genes in heterokaryons depends on gene dosage. Journal of Cell Biology 102:124-130.(PDF)

Blau, H.M., Pavlath, G.K., Hardeman, E.C., Chiu, C.-P., Silberstein, L., Webster, S.G., Miller, S.C. and Webster, C. (1985) Plasticity of the differentiated state. Science 230:758-766.(PDF)

Chiu, C.P. and Blau, H.M. (1985) 5-Azacytidine permits gene activation in a previously non-inducible cell type. Cell 40:417-424.(PDF)

Bains, W., Ponte, P., Blau, H. and Kedes, L. (1984) Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro. Molecular and Cellular Biology 4:1449-1453.(PDF)

Chiu, C.P. and Blau, H.M. (1984) Reprogramming cell differentiation in the absence of DNA synthesis. Cell 37:879-887.(PDF)

Gunning, P., Ponte, P., Blau, H.M. and Kedes, L. (1983) Alpha-skeletal and alpha-cardiac actin genes are co-expressed in adult human skeletal muscle and heart. Molecular and Cellular Biology 3:1985-1995.(PDF)

Ponte, P., Gunning, P., Blau, H.M. and Kedes, L. (1983) Human actin genes are single copy for a-skeletal and a-cardiac actin but multicopy for ß- and g-cytoskeletal genes: 3' untranslated regions are isotype specific, but are conserved in evolution. Molecular and Cellular Biology 3:1783-1791.

Blau, H.M., Webster, C. and Pavlath, G.K. (1983) Defective myoblasts identified in Duchenne muscular dystrophy. PNAS 80:4856-4860.(PDF)

Blau, H.M., Chiu, C.-P. and Webster, C. (1983) Cytoplasmic activation of human nuclear genes in stable heterokaryons. Cell 32:1171-1180.(PDF)

Gunning, P., Ponte, P, Okayama, H., Engel, J., Blau, H.M. and Kedes, L. (1983) Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: Skeletal but not cytoplasmic actins have an amino terminal cysteine that is subsequently removed. Molecular and Cellular Biology 3:787-795.(PDF)

Blau, H.M., Webster, C., Chiu, C.-P., Guttman, S. and Chandler, F. (1983) Differentiation properties of pure populations of human dystrophic muscle cells. Experimental Cell Research 144:495-503.(PDF)

Blau, H.M., Kaplan, I., Tao, T.W. and Kriss, J.P. (1983) Thyroglobulin-independent, cell-mediated cytotoxicity of human eye muscle cells in tissue culture by lymphocytes of a patient with Graves' Ophthalmopathy. Life Sci. 32:45-53.

Blau, H. M. and Webster, C. (1981) Isolation and characterization of human muscle cells. PNAS 78:5623-5627.

Blau, H.M. and Epstein, C.J. (1979) Manipulation of myogenesis in vitro: Reversible inhibition by DMSO. Cell 17:95-108.

Blau, H.M. and Kafatos, F.C. (1979) Morphogenesis of the silkmoth chorion: Patterns of distribution and insolubilization of the structural proteins. Developmental Biology 72:211-225.

Blau, H.M. and Kafatos, F.C. (1978) Secretory kinetics in the follicular cells of silkmoths during eggshell formation. Journal of Cell Biology 78:131-151.

Invited Chapters

Ho AT, Blau HM (2016) Noninvasive Tracking of Quiescent and Activated Muscle Stem Cell (MuSC) Engraftment Dynamics In Vivo. In Methods Mol Biol. 1460:181-9. doi: 10.1007/978-1-4939-3810-0_13. PubMed PMID: 27492173. (PDF)

Werner, A., Le Douarin, N., Sánchez Alvarado, A., Weissman, I., Jaenisch, R., Smith, A., Blau, H., Fuchs, E., Broccoli, V., Ricordi, C and Vicuña, R. (2012) Statement: Working group on New developments in Stem Cell Research: Induced pluripotent stem cells and their possible applications in medicine. Pontifica Academia Scientiarvm, Extra Series 39, The Pontifical Academy of Sciences, Vatican City.

Cosgrove, B.D. and Blau, H.M. (2011) Skeletal muscle stem cells. Chapter 20 In Principles of Regenerative Medicine (Second Edition), (A. Atala, R. Lanza, J.A. Thomson and R.M. Nerem, eds.) Elsevier Academic Press, pp. 347-363.

Lutolf, M.P. and Blau, H.M. (2009) Control of adult stem cell function in bioengineered in vivo niches. In Advances in Material Design for Regenerative Medicine, Drug Delivery, and Targeting/Imaging, (V. P. Shastri, A. Lendlein, L. Liu, A. Mikos, S. Mitragotri, eds.) Mater. Res. Soc. Symp. Proc. Volume 1140, Cambridge University Press, Warrendale, PA.

Blau, H.M., Sacco, A. and Gilbert, P.M. (2009) Skeletal muscle stem cells. In Essentials of Stem Cell Biology, 2nd Edition (R. Lanza et al., eds.), Academic Press Inc., San Diego, CA, pp. 249-257.

Lutolf, M.P. and Blau, H.M. (2009) Control of adult stem cell function in bioengineered artificial niches. In Advances in Tissue Engineering (J. Polak, ed.) World Scientific Publishing Company, Singapore, Chapter 9.

von Degenfeld, G., Wehrman, T.S. and Blau, H.B. (2009) Imaging b-galactosidase activity in vivo using sequential reporter-enzyme luminescence. Chapter 20 In Bioluminescence Methods and Protocols, 2nd ed. (P.B. Rich, C. Douillet, eds.) Humana Press, pp. 249-259.

Sacco, A., Glbert, P.M., Blau, H.M. (2008) “Self-renewal, stem cell. In Encyclopedia of Stem Cell Research (Svendsen and Ebert, eds.) SAGE Publications, Thousand Oaks, CA, pp. 493-496.

Pomerantz, J.H. and Blau, H.M. (2008) Skeletal muscle stem cells. In Principles of Regenerative Medicine, (A. Atala, R. Lanza, J.A. Thomson, R.M. Nerem, eds.) Elsevier Academic Press, pp. 376-397.

Blau, H.M. (2007) Adult stem cells: prospects for reprogramming bone marrow derivatives in stable heterokaryons. In Stem Cell Technology and Other Innovative Therapies, (Working Group, 10-11 November 2003), Vatican City, pp. XXXVII-152.

Pomerantz, J. and Blau, H.M. (2006) Adult stem cells. In Encyclopedia of Molecular Cell Biology and Molecular Medicine, (R. Meyers, ed.) Wiley-CH.

LaBarge, M.A. and Blau, H.M. (2004) Skeletal muscle stem cells. Chapter 37 In Handbook of Stem Cells, Vol. 2: Adult and Fetal Stem Cells, (R. Lanza, H. Blau, et al., eds.) Academic Press, Elsevier, Burlington, MA, pp. 395-403.

Brazelton, T.R. and Blau, H.M. (2004) Plasticity of circulating adult stem cells. In Lung Development and Regeneration, (D. Massaro, ed.) Marcel Dekker, Inc., New York, NY, pp. 217-246.

Doyonnas, R. and Blau, H.M. (2003) What is the future of Stem Cell Research? Whether entity or function? In Stem Cells Handbook, (S. Sell, ed.) Humana Press Inc., Totowa, NJ, pp. 491-499.

Banfi, A, Springer M.L. and Blau, H.M. (2002) Myoblast-mediated gene transfer for therapeutic angiogenesis. In Gene Therapy Methods. Methods in Enzymology (M.I., Phillips, ed.) Academic Press, San Diego, pp. 145-157.

Blau, H.M. and Rossi, F.M.V. (2002) Regulatable expression. In Encyclopedia of Molecular Medicine, vol 5. (T.E. Creighton, ed.) John Wiley & Sons, Inc., New York, pp. 2747-2750.

Blakely, B.T., Rossi, F.M.V., Wehrman, T.S., Charlton, C.A. and Blau, H.M. (2002) Protein interactions in live cells monitored by b-galactosidase complementation. In Protein-Protein Interactions: A Molecular Cloning Manual, (E. Golemis, ed.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 407-414.

Ozawa, C.R., Springer, M.L. and Blau, H.M. (2000) A novel means of drug delivery: myoblast-mediated gene therapy and regulatable retroviral vectors. In Annual Review of Pharmacology and Toxicology 40. (A.K. Cho, ed.) Annual Reviews, Inc., Palo Alto, pp. 295-317.

Rossi, F.M.V., Blakely, B.T., Charlton, C.A. and Blau, H.M. (2000) Monitoring protein-protein interactions in live mammalian cells by b-galactosidase complementation. In Applications of Chimeric Genes and Proteins. Methods in Enzymology, vol. 328. (J.N. Abelson, S.D. Emr, J. Thorner, eds.) Academic Press, San Diego, pp. 231-251.

Ozawa, C.R., Springer, M.L. and Blau, H.M. (2000) Ex vivo gene therapy using myoblasts and regulatable retroviral vectors. In Gene Therapy: Therapeutic Mechanisms and Strategies. (N.S. Templeton, D.D. Lasic, eds.) Marcel Dekker, Inc., New York, pp. 61-80; 2nd edition (2004) In Gene and Cell Therapy: Therapeutic Mechanisms and Strategies (N.S. Templeton, ed.), pp. 147-164.

Blau, H.M. and Blakely, B.T. (1999) Plasticity of cell fate: Insights from heterokaryons. In Seminars in Cell & Developmental Biology, vol. 10. (A. Colman, ed.) Academic Press, San Diego, pp. 267-272.

Rando, T.A. and Blau, H.M. (1997) Methods for myoblast transplantation. In Methods in Muscle Biology, Methods in Cell Biology series, vol. 52 (C.P. Emerson, H.L. Sweeney, eds.), Academic Press, San Diego, pp. 261-272.

Springer, M.L., Rando, T.A. and Blau, H.M. (1997) Gene delivery to muscle. In Current Protocols in Human Genetics, Unit 13.4 (A.L. Boyle, ed.), John Wiley & Sons, Inc., New York, pp. 13.4.1-13.4.19. [2nd edition: 2001), (A.L. Boyle and A. Rosenzweig, eds.), pp. 13.4.1-13.4.21].

Dhawan, J. and Blau, H.M. (1995) Systemic delivery of recombinant proteins by genetically engineered myoblasts. In Trends and Future Perspectives in Peptide and Protein Drug Delivery (V.H.L. Lee, M. Hashida, Y. Mizushima, eds.), Harwood Academic Publishers GMBH, Switzerland, pp. 351-364.

Blau, H.M. (1994) Heterokaryons reveal that differentiation requires continuous regulation. In The Legacy of Cell Fusion (S. Gordon, ed.), Oxford University Press, Oxford, pp. 3-16.

Blau, H.M., Pavlath, G.K. and Dhawan, J. (1993) Myoblast mediated gene therapy. In Tissue Engineering (E. Bell, ed.), Birkhauser, Boston, pp. 37-47.

Blau, H.M. (1993) Plasticity of the differentiated state. In Gene Expression: General and Cell-Type-Specific (M. Karin, ed.), Birkhauser, Boston, pp. 25-42.

Blau, H.M. (1992) Regulating the myogenic regulators. In The Molecular Biology of Muscle, Society for Experimental Biology, Symposium No. 46 (A. El Haj, ed.), Cambridge University Press, pp. 9-18.

Blau, H.M., Blakely, B.T., Pan, L.C., Schaefer, B.W., Peterson, C.A., Rastinejad, F., Rohrer, D., and Hwung, Y.-P. (1992) A genetic approach to cloning regulators of mammalian differentiation. In Molecular and Cellular Biology of Gene Expression in Neuromuscular Development and Disease, UCLA Symposia on Molecular and Cellular Biology (A. Kelly, H.M. Blau, eds.), Raven Press, New York, pp.115-129

Blau, H.M., Pavlath, G.K., Gussoni, E., Steinman, L., Miller, R.G., Sharma, K. (1992) Myoblast transfer in DMD: Problems in the interpretation of efficiency: A reply. Letter to the Editor, Muscle and Nerve 15:1209-1210.

Hughes, S.M. and Blau, H.M. (1991) Retroviral vectors as probes of muscle development. In Restorative Neurology (A. Wernig, ed.), Elsevier Science Publishers, pp. 11-14.

Miller, R.G., Mhaundar, S., Steinman, L., Almada, A., Pavlath, G.K., and Blau, H.M. (1991) Methodologic considerations in clinical studies of myoblast implantation. In Excerpta Medica International Congress Series (C. Angelini, G.A. Danieli, D. Fontanari eds.), Elsevier Science, Amsterdam, Holland, pp. 117-122.

Blau, H.M., Webster, C., Pavlath, G.K. (1990) Purification and Proliferation of Human Myoblasts Isolated with Flourecence Activated Cell Sorting. Advances in Experimental; Medicine and Biology, vol. 280 (R. Griggs, G. Karpati, eds) Plenun Publishing Corp., New York, NY, pp. 97-100.

Blau, H.M. and Hughes, S.M. (1990) Cell lineage in vertebrate development. In Current Opinion in Cell Biology 2:981-985.

Blau, H.M. and Hughes, S.M. (1990) Retroviral lineage markers for assessing myoblast fate in vivo. In International Conference on Myoblast Transfer Therapy (R. Griggs and G. Karpati, eds.), Plenum Press, New York, pp. 201-203.

Blau, H.M., Pavlath, G.K., Rich, K. and Webster, S.G. (1990) Localization of muscle gene products in nuclear domains: Does this constitute a problem for myoblast therapy? In International Conference on Myoblast Transfer Therapy (R. Griggs and G. Karpati, eds.), Plenum Press, New York, pp. 167-172.

Blau, H.M., Webster, C. and Pavlath, G.K. (1990) Purification and proliferation of human myoblasts isolated with fluorescence activated cell sorting. In International Conference on Myoblast Transfer Therapy (R. Griggs and G. Karpati, eds.), Plenum Press, New York, pp. 97-100.

Hughes, S.M. and Blau, H.M. (1990) Regulation of regional specialization in muscle fibers. In The Dynamic State of Muscle Fibers (D. Pette, ed.), Walter de Gruyter and Co., Berlin, pp. 265-277.

Blau, H.M., Pavlath, G.K., Chiu, C.-P., Hardeman, E., Miller, S., Blakely, B., Pan, L., Peterson, C. and Schäfer, B.W. (1989) Heterokaryons: A model system for studying cell commitment and differentiation. In Cellular and Molecular Biology of Muscle Development, UCLA Symposia on Molecular and Cellular Biology, new series, vol. 93 (L. Kedes and F. Stockdale, eds.), Alan R. Liss, Inc., New York, pp. 851-861.

Ham, R.G., St. Clair, J.A., Blau, H.M. and Webster, C. (1989) Serum-free media for growth and differentiation of human muscle satellite cells. In Cellular and Molecular Biology of Muscle Development, UCLA Symposia on Molecular and Cellular Biology, new series, vol. 93 (L. Kedes and F. Stockdale, eds.), Alan R. Liss, Inc., New York, pp. 905-914.

Bloch, E. and Blau, H.M. (1979; revised 1987) The family model with genetic counseling. In Marital and Family Therapy (Third Edition) (I.D. Glick, J.F. Clarkin, and D.R. Kessler, eds.), Grune and Stratton, Inc., Orlando, Florida.

Blau, H.M., Pavlath, G.K., Hardeman, E.C., Chiu, C.-P., Silberstein, L., Webster, S.G., Miller, S.C., and Webster, C. (1986) Plasticity of the differentiated state. In Biotechnology: The Renewable Frontier (D.E. Koshland, Jr., ed.), The American Association for the Advancement of Science, Washington, D.C., pp. 143-160.

Webster, C., Filippi, G., Rinaldi, A., Mastropaolo, C., Tondi, M., Siniscalco, M. and Blau, H.M. (1986) Linkage analysis of Duchenne phenotype and G6PD isotype in myoblasts from doubly heterozygous carriers. In Molecular Biology of Muscle Development, UCLA Symposia on Molecular and Cellular Biology (C. Emerson, D.A. Fischman, B. Nadal-Ginard, and M.A.Q. Siddiqui, eds.), Alan R. Liss, Inc., New York, 29:911-919.

Silberstein, L. and Blau, H.M. (1986) Two fetal-specific fast myosin isozymes in human muscle. In Molecular Biology of Muscle Development, UCLA Symposia on Molecular and Cellular Biology (C. Emerson, D.A. Fischman, B. Nadal-Ginard, and M.A.Q. Siddiqui, eds.), Alan R. Liss, Inc., New York, 29:253-262.

Minty, A.J., Hardeman, E., Gunning, P., Bains, W., Blau, H.M. and Kedes, L. (1986) Regulation of actin gene expression in mammalian striated muscle. In Molecular Biology of Muscle Development, UCLA Symposia on Molecular and Cellular Biology (C. Emerson, D.A. Fischman, B. Nadal-Ginard, and M.A.Q. Siddiqui, eds.), Alan R. Liss, Inc., New York, 29:507-519.

Blau, H.M., Pavlath, G.K., Chiu, C.-P., Hardeman, E. and Webster, C. (1986) Activation and expression of muscle genes in heterokaryons. In Molecular Biology of Muscle Development, UCLA Symposia on Molecular and Cellular Biology (C. Emerson, D.A. Fischman, B. Nadal-Ginard, and M.A.Q. Siddiqui, eds.), Alan R. Liss, Inc., New York, 29:105-116.

Blau, H.M., Webster, C., Pavlath, G.K. and Chiu, C.-P. (1985) Evidence for defective myoblasts in Duchenne muscular dystrophy. In Gene Expression in Muscle (R.C. Strohman and S. Wolf, eds.), Plenum Press, New York, pp. 85-110.

Blau, H.M., Chiu, C.-P., Pavlath, G.K. and Webster, C. (1985) Muscle gene expression in heterokaryons. In Gene Expression in Muscle (R.C. Strohman and S. Wolf, eds.), Plenum Press, New York, pp. 231-247.

Kedes, L., Blau, H.M., Gunning, P., Ponte, P., Chiu, C.-P., Bains, W., Engel, J. and Guttman, S. (1984) Molecular genetics of human myogenesis. In Experimental Biology and Medicine (H.M. Eppenberger and J.C. Perriard, eds.), S. Karger, Basel, 9:202-210.

Blau, H.M., Webster, C. and Chiu, C.-P. (1984) Cytoplasmic activation of muscle genes in stable mouse-human heterokaryons. An approach to the study of cell commitment to myogenesis. In Experimental Biology and Medicine (H.M. Eppenberger and J.-C. Perriard, eds.), S. Karger, Basel, 9:34-40.

Blau, H.M., Webster, C., Chiu, C.-P., Guttman, S., Adornato, B., and Chandler, F.C. (1982) Isolation and characterization of pure populations of normal and dystrophic human muscle cells. In Muscle Development: Molecular and Cellular Control (Pearson, M.L. and Epstein, H.F., eds.) Cold Spring Harbor Laboratory, New York, pp. 543-556.

Kafatos, F.C., Regier, J., Mazur, G.D., Nadel, M.R., Blau, H.M., Petri, W.H., Wyman, A.R., Gelinas, R.E., Moore, P.B., Paul, M., Efstratiadis, A., Vournakis, J.N., Goldsmith, M.R., Hunsley, J.R., Baker, B., Nardi, J., and Koehler, M. (1977) The eggshell of insects: Differentiation-specific proteins and the control of their synthesis and accumulation during development. In Results and Problems in Cell Differentiation (W. Beermann, ed.), Springer-Verlag, Berlin, 8:45-145.

Books

Lanza, R., Blau, H.M., et al., eds. (2003) Handbook of Adult and Fetal Stem Cells, Academic Press, Elsevier, Burlington, MA.

Blau, H.M. and Watt, F., eds. (1993) Cell differentiation. In Current Opinions in Cell Biology, Vol. 5, Current Biology LTD, London.

Kelly, A. and Blau, H.M., eds. (1992) Molecular and Cellular Biology of Gene Expression in Neuromuscular Development and Disease. In UCLA Symposia on Molecular and Cellular Biology, Raven Press, New York.

Committee on Ethics Publications

Ruark, J.E., Raffin, T.A., and the Stanford University Medical Center Committee on Ethics including H.M. Blau. (1988) Initiating and withdrawing life support. N. Engl. J. Med. 318:25-30.

Thomas, J.A., Hamm, T.E., Jr., Perkins, P.L., Raffin, T.A. and the Stanford University Medical Center Committee on Ethics including H.M. Blau. (1988) Animal research at Stanford University. Principles, policies, and practices. N. Engl. J. Med. 318:1630-1632.

Greely, H.T., Hamm, T., Johnson, R., Price, C.R., Weingarten, R., Raffin, T., and the Stanford University Medical Center Committee on Ethics including H.M. Blau. (1989) The ethical use of human fetal tissue in medicine. N. Engl. J. Med. 320:1093-1096.

In the news

Park, Alice. The Cure for Aging. TIME magazine 2015.

Wade, Nicholas. Two New Paths to the Dream: Regeneration. The New York Times 2010.

Winslow, Ron and Naik, Gautam. New Clues on Regrowing Tissue. Wall Street Journal 2010.





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