Russell JJ, Theriot JA, Sood P, Marshall WF, Landweber LF, Fritz-Laylin L, Polka JK, Oliferenko S, Gerbich T, Gladfelter A, Umen J, Bezanilla M, Lancaster MA, He S, Gibson MC, Goldstein B, Tanaka EM, Hu CK and Brunet A (2017). Non-model model organisms. BMC Biol, 15: 55. Abstract PDF

Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B, Mounier R (2017). AMPKa1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. EMBO J, 36: 1946-1962. Abstract PDF

Han S, Schroeder EA, Silva-Garcia CG, Hebestreit K, Mair WB and Brunet A (2017). Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan. Nature, 544: 185-190. Abstract PDF

Kao AW, McKay A, Singh PP, Brunet A, Huang EJ (2017). Proganulin, lysosomal degradation and neurodegenerative diseases. Nature Rev Neuroscience, 18: 325-333. Abstract PDF

Brunet A and Rando T (2017). Interaction between epigenetic and metabolism in stem cell aging. Current Opinion in Cell Biology, 45: 1-7. Abstract PDF

Dulken BW, Leeman DS, Boutet SC, Hebestreit K and Brunet A (2017). Single-cell transcriptomic reveals heterogeneity and transcriptional dynamics in the neural stem cell lineage. Cell Reports, 18: 777-790. Abstract PDF



Mahmoudi S and Brunet A (2016). Burst of reprogramming: a path to extend lifespan? Cell, 167:1672-1674. Abstract PDF

Harel I, Valenzano DR and Brunet A (2016). Efficient genome engineering approaches for the short-lived African turquoise killifish. Nature Protocols, 11:210-2028. Abstract PDF African Killifish Genome Browser

Ahlenius H, Chanda S, Webb AE, Yousif I, Karmasin J, Prusiner SB, Brunet A Sudhöf TC and Wernig M (2016). FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice. Proc Natl Acad Sci,113:8514-8519. Abstract PDF

Booth LN and Brunet A (2016). The aging epigenome. Molecular Cell, 62:728-44. Abstract PDF

Webb AE, Kundaje A and Brunet A (2016). Characterization of the direct targets of FOXO transcription factors throughout evolution. Aging Cell, 15:673-85. Abstract PDF

Yeo R and Brunet A (2016). Deconstructing dietary restriction: a case for systems approaches in aging. Cell Metabolism, 23:395-96. Abstract PDF


Valenzano DR*, Benayoun BA*, Singh PP*, Zhang E, Etter PD, Hu CK, Clément-Ziza M, Willemsen D, Cui R, Harel I, Machado BE, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA and Brunet A (2015). The African turquoise killifish genome provides insights into evolution and genetic architecture of lifespan. Cell, 163:1539-54. *Equal contribution. Abstract PDF African Killifish Genome Browser

Harel I and Brunet A (2015). The African turquoise killifish: a model for exploring vertebrate aging and diseases in the fast lane. Cold Spring Harb Quant Biol, pii: 027524. Abstract PDF 

Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM and Brunet A (2015). Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large scale substrate prediction. Cell Metabolism, 22:907-21. Abstract PDF

Schroeder EA and Brunet A (2015). Lipid profiles and signals for long life. Trends Endocrinol Metab, 26:589-92. Abstract PDF

Pech MF*, Garbuzov A*, Hasegawa K, Sukhwani M, Zhang RJ, Benayoun BA, Brockman SA, Lin S, Brunet A, Orwig KE and Artandi SE (2015). High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells. Genes&Development 29:2420-34. *Equal contribution. Abstract

Benayoun BA*, Pollina EA* and Brunet A (2015) Epigenetic regulation of aging: linking environmental input to genomic stability. Nature Review Mol Cell Biol16:593-610. *Equal contribution. Abstract PDF

Booth LN and Brunet A (2015) Shockingly early: Chromatin-mediated loss of the heat shock response. Molecular Cell 59:515-16. Abstract PDF

Dulken B and Brunet A (2015) Stem cell aging and sex: are we missing something? Cell Stem Cell 16:588-90. Abstract PDF

Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE and Brunet A (2015) A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell 160:1013-26. Abstract PDF

Han S and Brunet A (2015) Cell biology: Lysosomal lipid lengthens life span. Science, 347: 32-33. Abstract PDF

Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O'Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J and Wernig M (2015) Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis. Cell Stem Cell, 16:39-50. Abstract PDF



Benayoun BA*, Pollina EA*, Ucar D*, Mahmoudi S, Karra K, Wong E, Devarajan K, Daugherty AC, Kundaje A, Mancini E, Rando TA, Snyder MP, Baker JC, Cherry M and Brunet A (2014) H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell, 158:673-688. *Equal contribution. Abstract PDF Database Correction

Maures TJ, Booth LN, Benayoun BA, Izrayelit Y, Schroeder FC and Brunet A (2014) Males shorten the life span of C. elegans hermaphrodites via secreted compounds. Science, 343:541-544. Abstract PDF

Webb AE and Brunet A (2014) FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci., 39: 159-169.4. Abstract PDF

Leeman DS and Brunet A (2014) Stem cells: Sex specificity in the blood. Nature, 505:488-490. Abstract PDF

Gopinath SD, Webb AE, Brunet A and Rando TA (2014) FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal. Stem Cell Reports, 2: 414-426. Abstract PDF



Wapinski OL, Vierbuchen T, Qu K, Lee QY, Chanda S, Fuentes DR, Giresi PG, Ng YH, Marro S, Neff NF, Drechsel D, Martynoga B, Castro DS, Webb AE, Südhof TC, Brunet A, Guillemot F, Chang HY and Wernig M (2013) Hierarchichal mechanisms for direct reprogramming of fibroblasts to neurons. Cell, 155:621-635. Abstract PDF

Webb AE, Pollina EA, Vierbuchen T, Urbán N, Ucar D, Leeman DS, Martynoga B, Sewak M, Rando TA, Guillemot F, Wernig M and Brunet A. FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis. Cell Reports 4: 477-491. Abstract PDF

Liu L, Cheung TH, Charville GW, Urgo BM, Leavitt T, Shih J, Brunet A, and Rando TA. Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging. Cell Reports 4: 189-204. Abstract PDF

Rafalski VA, Ho PP, Brett JO, Ucar D, Dugas JC, Pollina EA, Chow LM, Ibrahim A, Baker SJ, Barres BA, Steinman L and Brunet A (2013) Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain. Nature Cell Biology 15: 614-624. Abstract PDF

Webb AE and Brunet A (2013) FOXO flips the longevity SWItch.
Nature Cell Biology 15: 444-446.
Abstract PDF

Lim JP and Brunet A (2013) Bridging the transgenerational gap with epigenetic memory. Trends in Genetics 29: 176-186. Abstract PDF



Rafalski VA, Mancini E and Brunet A (2012) Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate Journal of Cell Science 125: 5597-608. Abstract PDF

Salih DA, Rashid AJ, Colas D, de la Torre-Ubieta L, Zhu RP, Morgan AA, Santo EE, Ucar D, Devarajan K, Cole CJ, Madison DV, Shamloo M, Butte AJ, Bonni A, Josselyn SA, Brunet A (2012) FoxO6 regulates memory consolidation and synaptic function. Genes & Development 26:2780-801. Abstract PDF Supplemental PDF

Mahmoudi S and Brunet A (2012) Aging and reprogramming: a two-way street. Current Opinion in Cell Biology, 24:744-756. Abstract PDF

Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, and Brunet A (2012) Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging, 4:462-79. Abstract PDF

Benayoun BA and Brunet A (2012) Epigenetic memory of longevity in Caenorhabditis elegans. Worm, 1:1: 1-5. Abstract PDF

Han S and Brunet A (2012) Histone methylation makes its mark on longevity. Trends in Cell Biology, 22:42-49. Abstract PDF



Valenzano DR, Sharp S and Brunet A (2011) Transposon-mediated transgenesis in the short-lived African killifish Nothobranchius furzeri, a vertebrate model for aging. G3, Genes Genome Genetics, 1: 531-538. PDF Cover article.

Banko MR , Allen JJ, Schaffer BE, Wilker EW, Tsou P, White KL, Villén J, Wang B, Kims SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, and Brunet A (2011). Chemical genetic screen for AMPKalpha2 substrates uncovers a network of proteins involved in mitosis. Molecular Cell, 44: 878-892. Abstract PDF Supplementary information

Greer EL, Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y and Brunet A (2011). Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature (Article), 479: 365-371. Abstract PDF Supplementary information

Maures TJ, Greer EL, Hauswirth AG and Brunet A (2011). H3K27 demethylase UTX-1 regulates
C. elegans lifespan in a germline-independent, insulin-dependent, manner. Aging Cell, 10: 980-990.
Abstract PDF

Brunet A (2011) A CRTCal link between energy and life span. Cell Metabolism, 6: 358-360. Abstract PDF

Pollina EA and Brunet A (2011) Epigenetic regulation of aging stem cells. Oncogene, 30: 3105-3126. Abstract PDF

Arnold CP, Tan R, Zhou B, Yue SB, Schaffert S, Biggs JR, Doyonnas R, Lo MC, Perry JM, Renault VM, Sacco A, Somervaille T, Viatour P, Brunet A, Cleary ML, Li L, Sage J, Zhang DE, Blau HM, Chen C and Chen CZ (2011) MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Research, 21: 798-810. Abstract PDF

Renault VM, Thekkat PU, Hoang KL, White JL, Brady CA, Kenzelmann Broz D, Venturelli OS, Johnson TM, Oskoui PR, Xuan Z, Santo EE, Zhang MQ, Vogel H, Attardi LD and Brunet A (2011) The pro-longevity gene FoxO3 is a direct target gene of the p53 tumor suppressor. Oncogene, 30: 3207-3221. Abstract PDF

Brett JO, Renault VM, Rafalski VA, Webb AE and Brunet A (2011) The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. Aging, 3: 108-124. Abstract PDF

Rafalski VA and Brunet A (2011) Energy metabolism in adult neural stem cell fate. Progress in Neurobiology, 93: 182-203. Abstract PDF



Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O and Brunet A (2010) Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature, 466: 383-387. Abstract PDF

de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller U, Salih DA, Rowitch D, Brunet A and Bonni A (2010) A FOXO-Pak1 transcriptional pathway controls neuronal polarity. Genes & Development, 8: 799-813. Abstract PDF



Renault VM, Rafalski VA, Morgan AA, Salih DAM, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ and Brunet A (2009) FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell, 5: 527-539. Abstract PDF

Valenzano DR, Kirschner J, Kamber RA, Zhang E, Weber D, Cellerino A, Englert C, Platzer M, Reichwald K, and Brunet A (2009) Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri. Genetics, 183: 1385-1395. Abstract PDF

Greer EL, Banko MR and Brunet A (2009) AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity. Annals NY Academy of Science, 1170: 688-692. Abstract PDF

Brunet A (2009) Cancer: when restriction is good. Nature, 458: 713-714. Abstract PDF

Greer EL and Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell, 8: 113-127. Abstract PDF



Greer EL and Brunet A (2008) Signaling networks in aging. Journal of Cell Science , 121: 407-412. Abstract PDF Poster

Greer EL and Brunet A (2008) FoxO transcription factors in ageing and cancer. Acta Physiology (Oxf), 192: 19-28. Abstract

Salih DA and Brunet A (2008) FoxO transcription factors in the maintenance of cellular homeostasis during aging. Current Opinion in Cell Biology, 20: 126-136. Abstract PDF

Calnan DR and Brunet A (2008) The FoxO code. Oncogene, 27: 2276-2288. Abstract PDF



Brunet A (2007) Aging and cancer: killing two birds with one worm. Nature Genetics, 39: 1306-1307. Abstract PDF

Greer EL, Dowlatshahi D, Banko MR, Hoang K, Blanchard D and Brunet A (2007) An AMPK-FOXO pathway mediates the extension of lifespan induced by a novel method of dietary restriction in C. elegans. Current Biology, 17: 1646-1656. Abstract PDF

Brunet A and Rando T (2007) From stem to stern. Nature, 449: 288-289. Abstract PDF

Greer EL, Oskoui PR, Banko, MR, Maniar JM, Gygi MP, Gygi SP and Brunet A (2007) The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. Journal of Biological Chemistry, 282: 30107-30119. Abstract PDF

Carter ME and Brunet A (2007) FOXO transcription factors. Current Biology 7(4): R113-114. PDF



Greer EL and Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene, 24: 7410-7425. Abstract PDF


Before 2005 (selected publications)

Brunet A, Sweeney L, Sturgill F, Chua K, Greer P, Lin Y, Tran H, Ross S, Mostoslavsky R, Cohen H, Hu L, Cheng H, Jedrychowsky M, Gygi S, Sinclair D, Alt F and Greenberg ME (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science, 303: 2011-2015. Abstract PDF

Tran H, Brunet A, Griffith E and Greenberg ME (2003) The Many Forks in FOXO’s Road. Science STKE, (172):RE5. Abstract PDF

Tran H*, Brunet A*, Grenier J, Datta S, Fornace Jr A, Distefano P, Chiang L and Greenberg ME (2002) DNA repair pathway stimulated by the Forkhead transcription factor FOXO3a (FKHRL1) through the GADD45 protein. Science, 296: 530-534. *Equal contribution. Abstract PDF

Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni J, Dala S, DeCaprio J, Greenberg ME and Yaffe M (2002) 14-3-3 Transits to the Nucleus and actively participates in dynamic nucleo-cytoplasmic transport. Journal of Cell Biology, 156: 817-828. Abstract PDF

Brunet A*, Park J*, Tran H, Hu LS, Hemmings BA and Greenberg ME (2001) The protein kinase SGK mediates survival signals by phosphorylating the Forkhead transcription factor FKHRL1/FOXO3a. Molecular and Cellular Biology, 21: 952-965. *Equal contribution. Abstract PDF

Brunet A, Datta S and Greenberg ME (2001) Transcription-dependent and independent control of neuronal survival by the Pi3K-Akt signaling pathway. Current Opinion in Neurobiology, 11: 297-305. Abstract PDF

Brunet A, Bonni A, Zigmond, M, Lin MZ, Juo P, Hu L, Anderson M, Arden K, Blenis J and Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 96: 857-868. Abstract PDF

Bonni A, Brunet A, West AE, Datta SR, Takasu MA and Greenberg ME (1999). Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and transcription- independent mechanisms. Science, 286: 1358-1362. Abstract PDF

Brunet A, Roux D, Lenormand P, Dowd S, Keyse S and Pouysségur J (1999). Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO Journal, 18: 664-74. Abstract PDF

Brunet A and Pouysségur J (1996) Identification of MAP kinase domains by re-directing stress signals into growth factor responses. Science, 272: 1652-1655. Abstract PDF