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Preprints Zhao X, Yan X, Contrepois K, Vallania F, Ellenberger M, Kashiwagi CM, Gagnon SD, Siebrand CJ, Cabruja M, Traver GM, McKay A, Hornburg D, Khatri P, Snyder MP, Zare RN and Brunet A (2022). Lipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging. BioRxiv PDF
2024 Ruetz TJ, Pogson AN*, Kashiwagi CM*, Gagnon SD, Morton B, Sun ED, Na J, Yeo RW, Leeman DS, Morgens DW, Tsui CK, Li A, Bassik MC and Brunet A (2024) CRISPR-Cas9 screens reveal regulators of ageing in neural stem cells. Nature, 634:1150-1159. Abstract PDF Singh PP*, Reeves GA*, Contrepois K, Papsdorf K, Miklas JW, Ellenberger M, Hu C-K, Snyder MP and Brunet A (2024) Evolution of diapause in the African turquoise killifish by remodeling the ancient regulatory gene landscape. Cell, 187:3338-3356.e30. Abstract PDF Chen Y*, Harel I*, Singh PP, Ziv I, Moses E, Goshtchevsky U, Machado BE, Brunet A* and Jarosz D* (2024) Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate. Developmental Cell, 59:1892-1911.e13. Abstract PDF Harel I*, Chen Y*, Ziv I, Singh PP, Navarro Negredo P, Goshtchevsky, Wang W, Astre G, Moses E, McKay A, Machado BE, Hebestreit K, Yin S, Sánchez Alvarado A, Jarosz D* and Brunet A* (2024) Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties. Cell Reports, 43:112787. Abstract PDF Xu L, Ramirez-Matias J, Hauptschein M, Sun ED, Lunger JC, Buckley MT, and Brunet A (2024) Restoration of neural progenitors by partial reprogramming in the aged neurogenic niche. Nature Aging, 4:546-567. Abstract PDF Sun ED, Ma R, Navarro Negredo P, Brunet A, and Zou J (2024) TISSUE: uncertainty-calobrated prdiction of single-cell spatial transcriptomics improves downstream analaysis. Nature Methods, 21:444-454. Abstract PDF Reyes JM, Ayala T, Zhang L, Bortoletto AS, Rosas C, Chen C-W, Waldvogel SM, Guzman AG, Aguilar R, Gupta S, Liu L, Buckley MT, Patel K, Marcogliese AN, Li Y, Curry CV, Rando TA, Brunet A, Parchem RJ, Rau RE, and Goodell MA (2024) Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation. iScience, DOI: 10.1016/j.isci.2024.109122. Abstract PDF
2023 Silva-García CG, Láscarez-Lagunas LI, Papsdorf K, Heinz C, Prabhakar A, Morrow CS, Pajuelo Torres L, Sharma A, Liu J, Colaiácovo MP, Brunet A, Mair WB (2023) The CRTC-1 transcriptional domain is required for COMPASS-complex mediated longevity in C. elegans. Nature Aging, 3:1358-1371. doi: 0.1038/s43587-023-00517-8. Abstract PDF Yeo RW*, Zhou OY*, Zhong BL, Sun ED, Navarro Negredo P, Nair S, Sharmin M, Ruetz TZ, Wilson M, Kundaje A, Dunn AR, and Brunet A (2023) Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell adhesion and migration during aging. Nature Aging, 3:866-893. doi: 10.1038/s43587-023-00449-3. Abstract PDF Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-Garcia CG, Haseley NR, Murphy LM, Yao P, de Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, and Brunet A (2023) Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids. Nature Cell Biology, doi: 10.1038/s41556-023-01136-6. Abstract PDF Bedbrook CN*, Nath RD*, Nagvekar R, Deisseroth K, and Brunet A (2023) Rapid and precise genome-engineering in a naturally short-lived vertebrate. eLife, doi: 10.7554/eLife.80639. Abstract PDF Buckley MT*, Sun E*, Benson GM, Liu L, Schaum N, Xu L, Reyes JM, Goodell MA, Weissman IL, Wyss-Coray T, Rando TA and Brunet A (2023) Cell type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain. Nature Aging, 3:121-137. Abstract PDF Liu L, Kim S, Buckley MT*, Reyes JM, Kang J, Tian L, Wang M, Lieu A, Mao M, Rodriguez-Mateo C, Ishak HD, Jeong M, Wu JC, Goodell MA, Brunet A, Rando TA (2023) Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalin aging . Cell Stem Cell, S1934-5909(23)00087-5, doi: 10.1016/j.stem.2023.03.016. Abstract PDF Chen J, Khondker R, and Brunet A (2023) Breeding and reproduction of the African turquoise killifish Nothobranchius furzeri. Cold Spring Harb Protoc, doi: 10.1101/pdb.prot107816. Abstract PDF Nath RD*, Bedbrook CN*, Nagvekar R, and Brunet A (2023) Husbandry of the African turquoise killifish Nothobranchius furzeri. Cold Spring Harb Protoc, doi: 10.1101/pdb.prot107738. Abstract PDF Bedbrook CN*, Nath RD*, Barajas R and Brunet A (2023) Life span assessment in the African turquoise killifish Nothobranchius furzeri. Cold Spring Harb Protoc, doi: 10.1101/pdb.prot107917. Abstract PDF Reeves GA, Singh PP, and Brunet A (2023) Chromatin accessibility profiling and data analysis using ATAC-seq in Nothobranchius furzeri. Cold Spring Harb Protoc, doi: 10.1101/pdb.prot107747. Abstract PDF Boos F, Chen J, and Brunet A (2023) The African turquoise killifish: A scalable vertebrate model for aging and other complex phenotypes. Cold Spring Harb Protoc, doi: 10.1101/pdb.over107737. Abstract PDF Zhou OY and Brunet A (2023) Seeig is believing: old clones die young. Nature Aging, 3: 371-373. PDF Brunet A, Goodell MA and Rando TA (2023). Ageing and rejuvenation of tissue stem cells and their niches. Nature Review Molecular and Cellular Biology, doi: 10.1038/s41580-022-00510-w. Abstract PDF
2022 McKay A*, Costa EK*, Chen J*, Hu C-K, Chen X, Bedbrook CN, Khondker RC, Thielvoldt M, Singh, PP, Wyss-Coray T, and Brunet A (2022) An automated feeding system for the African killifish reveals effects of dietary restriction on lifespan and allows scalable measurement of associative learning. Elife PDF Booth LN, Shi C, Tantilert C, Yeo RW, Miklas, JW, Hebestreit K, Hollenhorst CN, Maures TJ, Buckley MT, Murphy CT* and Brunet A* (2022) Males induce premature demise of the opposite sex by multifaced strategies. Nature Aging, 2:809-823. PDF Miklas JW and Brunet A (2022). Long life depends on open communication. Nature Cell Biology, 24: 808-810. PDF
2021 Navarro Negredo P and Brunet A (2021) Unwanted help from T cells in the aging central nervous system. Nature Aging, 1: 330-331. PDF Cabruja M, Priotti J, Domizi P, Papsdorf K, Kroetz DL, Brunet A, Contrepois K, and Snyder MP (2021) In depth triacylglycerol profiling using MS3 Q-Trap mass spectrometry. Anal Chim Acta , 1184: 339023. PDF
2020 Wang W, Hu C-K, Zeng A, Alegre D, Hu D, Gotting K, Ortega Granillo A, Wang Y, Robb S, Schnittker R, Zhang S, Alegre D, Li H, Ross E, Zhang N, Brunet A, and Sánchez Alvarado A (2020) Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates. Science, 369: eaaz3090. Abstract PDF Yan X*, Zhao X*, Zhou Z*, McKay A, Brunet A, and Zare RN (2020) Cell-type-specific metabolic profiling achieved by combining desorption electrospray ionization mass spectrometry imaging and immunofluorescence staining. Anal Chem, doi: 10.1021/acs.analchem.0c02519. Abstract PDF Navarro Negredo P*, Yeo RW*, and Brunet A (2020) Aging and Rejuvenation of Neural Stem Cells and Their Niches. Cell Stem Cell, 27: 202-223. Abstract PDF Brunet A (2020) Old and new models for the study of human ageing. Nature Review Mol Cell Biol, doi: 10.1038/s41580-020-0266-4. Abstract PDF Vonk WIM, Rainbolt TK, Dolan PT, Webb AE, Brunet A, and Frydman J (2020) Differentiation drives widespread rewiring of the neural stem cell chaperone network. Molecular Cell, 78: 329-345.e9. Abstract PDF Hu C-K, Wang W, Brind'Amour J, Singh PP, Reeves GA, Lorincz MC, Sánchez Alvarado A and Brunet A (2020) Vertebrate diapause preserves organisms long term through Polycomb complex members. Science, 367: 870-874. Abstract PDF Miklas JW and Brunet A (2020) Support cells in the brain promote longevity. Science, 367: 365-366. Abstract PDF Ahadi S, Zhou W, Schüssler-Fiorenza Rose SM, Sailani MR, Contrepois K, Avina M, Ashland M, Brunet A, and Snyder M (2020) Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nature Medicine, 26: 83-90. Abstract PDF
2019 Mahmoudi S*, Mancini E*, Moore A, Xu L, Jahanbani F, Hebestreit K, Srinivasan R, Li X, Devarajan K, Prélot L, Ang CE, Shibuya Y, Benayoun BA, Chang ALS, Wernig M, Wysocka J, Longaker MT, Snyder MP and Brunet A (2019) Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature, 574: 553-558. Abstract PDF Booth LN, Maures TJ, Yeo RW, Tantilert C and Brunet A (2019) Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes. eLife, 8:e46418. Abstract PDF Dulken BW*, Buckley MT*, Navarro Negredo P*, Saligrama N, Cayrol R, Leeman DS, Benson GM, Boutet SC, Hebestreit K, Pluvinage JV, Wyss-Coray T, Weissman IL, Vogel H, Davis MM and Brunet A (2019) Single-cell analysis reveals T cell infiltration in old neurogenic niches. Nature, 571: 205-210. Abstract PDF
Singh PP*, Demmitt BA*, Nath RD*, and Brunet A (2019) The genetics of aging: a vertebrate perspective. Cell, 177: 200-220. Abstract PDF Benayoun BA, Pollina EA, Singh PP, Mahmoudi S, Harel I, Casey KM, Dulken BW, Kundaje A and Brunet A (2019) Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses. Genome Research, 29: 697-709. Abstract PDF Mahmoudi S*, Xu L* and Brunet A (2019) Turning back time with emerging rejuvenation strategies Nature Cell Biology, 21: 32-43. Abstract PDF
2018 Papsdorf K and Brunet A (2018) Linking lipid metabolism to chromatin regulation in aging Trends Cell Biol, 29: 97-116. Abstract PDF Lim JP, Fehlauer H, Das A, Saro G, Glauser DA, Brunet A, and Goodman MB (2018) Loss of CaMKI function disrupts salt aversive learning in C. elegans. J Neuroscience, 38: 6114-6129. Abstract PDF Contrepois K, Mahmoudi S, Ubhi BK, Papsdorf K, Hornburg D, Brunet A and Snyder M (2018) Cross-platform comparison of untargeted and targeted lipidomics approaches on aging mouse plasma.Scientific reports , 8: 17747. Abstract PDF Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, and Brunet A (2018) Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science, 359: 1277-1283. Abstract PDF Hu C-K and Brunet A (2018) The African turquoise killifish: A research organism to study vertebrate aging and diapause. Aging Cell, 17: e12757. Abstract PDF Dulken BW and Brunet A (2018) Same path, different beginnings. Nature Neuroscience, 21: 159-160. Abstract PDF Wagner JT, Singh PP, Romney AL, Riggs CL, Minx P, Woll SC, Roush J, Waren WC, Brunet A, and Podrabsky JF (2018) The genome of Austrofundulus limnaus offers insights into extreme vertebrate stress tolerance and embrynic development. BMC Genomics, 19: 155. Abstract PDF
2017 Daugherty AC*, Yeo RW*, Buenrostro JD, Greenleaf WJ, Kundaje A, and Brunet A (2017) Chromatin accessibility dynamics reveal novel functional enhancers in C. elegans. Genome Research, 27: 2096-2107. Abstract PDF Tan MH, Li Q, Shanmugam M, Piskol R, ...Pollina EA, Leeman DS,.... Brunet A, Conrad DF, Samuel CE, O'Connell MA, Walkley CR, Nishikura K and Li JB (2017) Dynamic landscape and regulation of RNA editing in mammals. Nature, 550: 249-254. Abstract PDF Russell JJ, Theriot JA, Sood P, Marshall WF, Landweber LF, Fritz-Laylin L, Polka JK, Oliferenko S, Gerbich T, Gladfelter A, Umen J, Bezanilla M, Lancaster MA, He S, Gibson MC, Goldstein B, Tanaka EM, Hu CK and Brunet A (2017) Non-model model organisms. BMC Biol, 15: 55. Abstract PDF Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B, Mounier R (2017) AMPKa1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. EMBO J, 36: 1946-1962. Abstract PDF Han S, Schroeder EA, Silva-Garcia CG, Hebestreit K, Mair WB and Brunet A (2017) Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan. Nature, 544: 185-190. Abstract PDF Kao AW, McKay A, Singh PP, Brunet A, and Huan EJ (2017) Progranulin, lysosomal degradation and neurodegenerative diseases. Nature Reviews Neuroscience, 18: 325-333. Abstract PDF Brunet A and Rando T (2017) Interaction between epigenetic and metabolism in stem cell aging. Current Opinion in Cell Biology, 45: 1-7. Abstract PDF Dulken BW, Leeman DS, Boutet SC, Hebestreit K and Brunet A (2017) Single-cell transcriptomic reveals heterogeneity and transcriptional dynamics in the neural stem cell lineage. Cell Reports, 18: 777-790. Abstract PDF
2016 Mahmoudi S and Brunet A (2016) Burst of reprogramming: a path to extend lifespan? Cell, 167:1672-1674. Abstract PDF Harel I, Valenzano DR and Brunet A (2016) Efficient genome engineering approaches for the short-lived African turquoise killifish. Nature Protocols, 11:210-2028. Abstract PDF African Killifish Genome Browser Ahlenius H, Chanda S, Webb AE, Yousif I, Karmasin J, Prusiner SB, Brunet A Sudhöf TC and Wernig M (2016) FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice. Proc Natl Acad Sci,113:8514-8519. Abstract PDF Booth LN and Brunet A (2016) The aging epigenome. Molecular Cell, 62:728-44. Abstract PDF Webb AE, Kundaje A and Brunet A (2016) Characterization of the direct targets of FOXO transcription factors throughout evolution. Aging Cell, 15:673-85. Abstract PDF Yeo R and Brunet A (2016) Deconstructing dietary restriction: a case for systems approaches in aging. Cell Metabolism, 23:395-96. Abstract PDF 2015 Valenzano DR*, Benayoun BA*, Singh PP*, Zhang E, Etter PD, Hu CK, Clément-Ziza M, Willemsen D, Cui R, Harel I, Machado BE, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA and Brunet A (2015) The African turquoise killifish genome provides insights into evolution and genetic architecture of lifespan. Cell, 163:1539-54. *Equal contribution. Abstract PDF African Killifish Genome Browser Harel I and Brunet A (2015) The African turquoise killifish: a model for exploring vertebrate aging and diseases in the fast lane. Cold Spring Harb Quant Biol, pii: 027524. Abstract PDF Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM and Brunet A (2015) Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large scale substrate prediction. Cell Metabolism, 22:907-21. Abstract PDF Schroeder EA and Brunet A (2015) Lipid profiles and signals for long life. Trends Endocrinol Metab, 26:589-92. Abstract PDF Pech MF*, Garbuzov A*, Hasegawa K, Sukhwani M, Zhang RJ, Benayoun BA, Brockman SA, Lin S, Brunet A, Orwig KE and Artandi SE (2015) High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells. Genes&Development 29:2420-34. *Equal contribution. AbstractBenayoun BA*, Pollina EA* and Brunet A (2015) Epigenetic regulation of aging: linking environmental input to genomic stability. Nature Review Mol Cell Biol16:593-610. *Equal contribution. Abstract PDF Booth LN and Brunet A (2015) Shockingly early: Chromatin-mediated loss of the heat shock response. Molecular Cell 59:515-16. Abstract PDF Dulken B and Brunet A (2015) Stem cell aging and sex: are we missing something? Cell Stem Cell 16:588-90. Abstract PDF Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE and Brunet A (2015) A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell 160:1013-26. Abstract PDF Han S and Brunet A (2015) Cell biology: Lysosomal lipid lengthens life span. Science, 347: 32-33. Abstract PDF Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O'Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J and Wernig M (2015) Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis. Cell Stem Cell, 16:39-50. Abstract PDF
2014 Benayoun BA*, Pollina EA*, Ucar D*, Mahmoudi S, Karra K, Wong E, Devarajan K, Daugherty AC, Kundaje A, Mancini E, Rando TA, Snyder MP, Baker JC, Cherry M and Brunet A (2014) H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell, 158:673-688. *Equal contribution. Abstract PDF Database Correction Maures TJ, Booth LN, Benayoun BA, Izrayelit Y, Schroeder FC and Brunet A (2014) Males shorten the life span of C. elegans hermaphrodites via secreted compounds. Science, 343:541-544. Abstract PDF Webb AE and Brunet A (2014) FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci., 39: 159-169.4. Abstract PDF Leeman DS and Brunet A (2014) Stem cells: Sex specificity in the blood. Nature, 505:488-490. Abstract PDF Gopinath SD, Webb AE, Brunet A and Rando TA (2014) FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal. Stem Cell Reports, 2: 414-426. Abstract PDF
2013 Wapinski OL, Vierbuchen T, Qu K, Lee QY, Chanda S, Fuentes DR, Giresi PG, Ng YH, Marro S, Neff NF, Drechsel D, Martynoga B, Castro DS, Webb AE, Südhof TC, Brunet A, Guillemot F, Chang HY and Wernig M (2013) Hierarchichal mechanisms for direct reprogramming of fibroblasts to neurons. Cell, 155:621-635. Abstract PDF Webb AE, Pollina EA, Vierbuchen T, Urbán N, Ucar D, Leeman DS, Martynoga B, Sewak M, Rando TA, Guillemot F, Wernig M and Brunet A. FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis. Cell Reports 4: 477-491. Abstract PDF Liu L, Cheung TH, Charville GW, Urgo BM, Leavitt T, Shih J, Brunet A, and Rando TA. Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging. Cell Reports 4: 189-204. Abstract PDF Rafalski VA, Ho PP, Brett JO, Ucar D, Dugas JC, Pollina EA, Chow LM, Ibrahim A, Baker SJ, Barres BA, Steinman L and Brunet A (2013) Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain. Nature Cell Biology 15: 614-624. Abstract PDF
Webb AE and Brunet A (2013) FOXO flips the longevity SWItch. Nature Cell Biology 15: 444-446. Abstract PDF Lim JP and Brunet A (2013) Bridging the transgenerational gap with epigenetic memory. Trends in Genetics 29: 176-186. Abstract PDF
2012 Rafalski VA, Mancini E and Brunet A (2012) Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate Journal of Cell Science 125: 5597-608. Abstract PDF Salih DA, Rashid AJ, Colas D, de la Torre-Ubieta L, Zhu RP, Morgan AA, Santo EE, Ucar D, Devarajan K, Cole CJ, Madison DV, Shamloo M, Butte AJ, Bonni A, Josselyn SA, Brunet A (2012) FoxO6 regulates memory consolidation and synaptic function. Genes & Development 26:2780-801. Abstract PDF Supplemental PDF Mahmoudi S and Brunet A (2012) Aging and reprogramming: a two-way street. Current Opinion in Cell Biology, 24:744-756. Abstract PDF Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, and Brunet A (2012) Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging, 4:462-79. Abstract PDF Benayoun BA and Brunet A (2012) Epigenetic memory of longevity in Caenorhabditis elegans. Worm, 1:1: 1-5. Abstract PDF Han S and Brunet A (2012) Histone methylation makes its mark on longevity. Trends in Cell Biology, 22:42-49. Abstract PDF
2011 Valenzano DR, Sharp S and Brunet A (2011) Transposon-mediated transgenesis in the short-lived African killifish Nothobranchius furzeri, a vertebrate model for aging. G3, Genes Genome Genetics, 1: 531-538. PDF Cover article. Banko MR , Allen JJ, Schaffer BE, Wilker EW, Tsou P, White KL, Villén J, Wang B, Kims SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, and Brunet A (2011). Chemical genetic screen for AMPKalpha2 substrates uncovers a network of proteins involved in mitosis. Molecular Cell, 44: 878-892. Abstract PDF Supplementary information Greer EL, Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y and Brunet A (2011). Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature (Article), 479: 365-371. Abstract PDF Supplementary information Maures TJ, Greer EL, Hauswirth AG and Brunet A (2011). H3K27 demethylase UTX-1 regulates Brunet A (2011) A CRTCal link between energy and life span. Cell Metabolism, 6: 358-360. Abstract PDF Pollina EA and Brunet A (2011) Epigenetic regulation of aging stem cells. Oncogene, 30: 3105-3126. Abstract PDF Arnold CP, Tan R, Zhou B, Yue SB, Schaffert S, Biggs JR, Doyonnas R, Lo MC, Perry JM, Renault VM, Sacco A, Somervaille T, Viatour P, Brunet A, Cleary ML, Li L, Sage J, Zhang DE, Blau HM, Chen C and Chen CZ (2011) MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Research, 21: 798-810. Abstract PDF Renault VM, Thekkat PU, Hoang KL, White JL, Brady CA, Kenzelmann Broz D, Venturelli OS, Johnson TM, Oskoui PR, Xuan Z, Santo EE, Zhang MQ, Vogel H, Attardi LD and Brunet A (2011) The pro-longevity gene FoxO3 is a direct target gene of the p53 tumor suppressor. Oncogene, 30: 3207-3221. Abstract PDF Brett JO, Renault VM, Rafalski VA, Webb AE and Brunet A (2011) The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. Aging, 3: 108-124. Abstract PDF Rafalski VA and Brunet A (2011) Energy metabolism in adult neural stem cell fate. Progress in Neurobiology, 93: 182-203. Abstract PDF
2010 Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O and Brunet A (2010) Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature, 466: 383-387. Abstract PDF de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller U, Salih DA, Rowitch D, Brunet A and Bonni A (2010) A FOXO-Pak1 transcriptional pathway controls neuronal polarity. Genes & Development, 8: 799-813. Abstract PDF
2009 Renault VM, Rafalski VA, Morgan AA, Salih DAM, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ and Brunet A (2009) FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell, 5: 527-539. Abstract PDF Valenzano DR, Kirschner J, Kamber RA, Zhang E, Weber D, Cellerino A, Englert C, Platzer M, Reichwald K, and Brunet A (2009) Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri. Genetics, 183: 1385-1395. Abstract PDF Greer EL, Banko MR and Brunet A (2009) AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity. Annals NY Academy of Science, 1170: 688-692. Abstract PDF Brunet A (2009) Cancer: when restriction is good. Nature, 458: 713-714. Abstract PDF Greer EL and Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell, 8: 113-127. Abstract PDF
2008 Greer EL and Brunet A (2008) Signaling networks in aging. Journal of Cell Science , 121: 407-412. Abstract PDF Poster Greer EL and Brunet A (2008) FoxO transcription factors in ageing and cancer. Acta Physiology (Oxf), 192: 19-28. Abstract Salih DA and Brunet A (2008) FoxO transcription factors in the maintenance of cellular homeostasis during aging. Current Opinion in Cell Biology, 20: 126-136. Abstract PDF Calnan DR and Brunet A (2008) The FoxO code. Oncogene, 27: 2276-2288. Abstract PDF
2007 Brunet A (2007) Aging and cancer: killing two birds with one worm. Nature Genetics, 39: 1306-1307. Abstract PDF Greer EL, Dowlatshahi D, Banko MR, Hoang K, Blanchard D and Brunet A (2007) An AMPK-FOXO pathway mediates the extension of lifespan induced by a novel method of dietary restriction in C. elegans. Current Biology, 17: 1646-1656. Abstract PDF Brunet A and Rando T (2007) From stem to stern. Nature, 449: 288-289. Abstract PDF Greer EL, Oskoui PR, Banko, MR, Maniar JM, Gygi MP, Gygi SP and Brunet A (2007) The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. Journal of Biological Chemistry, 282: 30107-30119. Abstract PDF Carter ME and Brunet A (2007) FOXO transcription factors. Current Biology 7(4): R113-114. PDF
2005 Greer EL and Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene, 24: 7410-7425. Abstract PDF
Before 2005 (selected publications) Brunet A, Sweeney L, Sturgill F, Chua K, Greer P, Lin Y, Tran H, Ross S, Mostoslavsky R, Cohen H, Hu L, Cheng H, Jedrychowsky M, Gygi S, Sinclair D, Alt F and Greenberg ME (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science, 303: 2011-2015. Abstract PDF Tran H, Brunet A, Griffith E and Greenberg ME (2003) The Many Forks in FOXO’s Road. Science STKE, (172):RE5. Abstract PDF Tran H*, Brunet A*, Grenier J, Datta S, Fornace Jr A, Distefano P, Chiang L and Greenberg ME (2002) DNA repair pathway stimulated by the Forkhead transcription factor FOXO3a (FKHRL1) through the GADD45 protein. Science, 296: 530-534. *Equal contribution. Abstract PDF Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni J, Dala S, DeCaprio J, Greenberg ME and Yaffe M (2002) 14-3-3 Transits to the Nucleus and actively participates in dynamic nucleo-cytoplasmic transport. Journal of Cell Biology, 156: 817-828. Abstract PDF Brunet A*, Park J*, Tran H, Hu LS, Hemmings BA and Greenberg ME (2001) The protein kinase SGK mediates survival signals by phosphorylating the Forkhead transcription factor FKHRL1/FOXO3a. Molecular and Cellular Biology, 21: 952-965. *Equal contribution. Abstract PDF Brunet A, Datta S and Greenberg ME (2001) Transcription-dependent and independent control of neuronal survival by the Pi3K-Akt signaling pathway. Current Opinion in Neurobiology, 11: 297-305. Abstract PDF Brunet A, Bonni A, Zigmond, M, Lin MZ, Juo P, Hu L, Anderson M, Arden K, Blenis J and Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 96: 857-868. Abstract PDF Bonni A, Brunet A, West AE, Datta SR, Takasu MA and Greenberg ME (1999). Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and transcription- independent mechanisms. Science, 286: 1358-1362. Abstract PDF Brunet A, Roux D, Lenormand P, Dowd S, Keyse S and Pouysségur J (1999). Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO Journal, 18: 664-74. Abstract PDF Brunet A and Pouysségur J (1996) Identification of MAP kinase domains by re-directing stress signals into growth factor responses. Science, 272: 1652-1655. Abstract PDF
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