Burns Lab
Research in our group explores the boundaries of modern organic synthesis to enable the more rapid creation of the highest molecular complexity in a predictable and controllable fashion. We are particularly inspired by natural products not only because of their importance as synthetic targets but also due to their ability to serve as invaluable identifiers of unanswered scientific questions.

One major focus of our research is selective halogenation of organic molecules. Dihalogenation and halofunctionalization encompass some of the most fundamental transformations in our field, yet methods capable of accessing relevant halogenated motifs in a chemo-, regio-, and enantioselective fashion are lacking.

We are also interested in the practical total synthesis of natural products for which there is true impetus for their construction due to unanswered chemical, medicinal, biological, or biophysical questions. We are specifically engaged in the construction of unusual lipids with unanswered questions regarding their physical properties and for which synthesis offers a unique opportunity for study.

"Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (–)-Deschloromytilipin A and (–)-Danicalipin A" Matthew L. Landry, Dennis X. Hu, Grace M. McKenna, Noah Z. Burns. J. Am. Chem. Soc. 2016, 138, 5150–5158. Article. Supporting information.

"Natural products: Emulation illuminates biosynthesis" Jaron A. M. Mercer, Noah Z. Burns. Nature Chem. 2015, 7, 860–861.

"Highly Selective Synthesis of Halomon, Plocamenone, and Isoplocamenone" Cyril Bucher, Richard M. Deans, Noah Z. Burns. J. Am. Chem. Soc. 2015, 137, 12784–12787. Article. Supporting information.

"Catalytic Chemo-, Regio-, and Enantioselective Bromochlorination of Allylic Alcohols" Dennis X. Hu, Fritz J. Seidl, Cyril Bucher, Noah Z. Burns. J. Am. Chem. Soc. 2015, 137, 3795–3798. Article. Supporting information.

"Catalytic Enantioselective Dibromination of Allylic Alcohols" Dennis X. Hu, Grant M. Shibuya, Noah Z. Burns. J. Am. Chem. Soc. 2013, 135, 12960–12963. Article. Supporting information.

Before Stanford:

Burns, N. Z.; Jacobsen, E. N. "Catalysis in Tight Spaces," Nature, 2012, 483, 278–279.

Burns, N. Z.; Witten, M. W.; Jacobsen, E. N. "Dual Catalysis in Enantioselective Oxidopyrylium-Based [5 + 2] Cycloadditions," J. Am. Chem. Soc. 2011, 133, 14578–14581.

Burns, N. Z.; Jacobsen, E. N. "Mannich Reaction," in Science of Synthesis, Stereoselective Synthesis, Vol. 2, De Vries, J. G.; Molander, G. A.; Evans, P. A., Eds.; Georg Thieme Verlag: Stuttgart, Germany, 2011; 785–834.

Sella, E.; Weinstain, R.; Erez, R.; Burns, N. Z.; Baran, P. S.; Shabat, D "Sulfhydryl-Based Dendritic Chain Reaction," Chem. Commun. 2010, 46, 6575–6577.

Burns, N. Z.; Krylova, I. N.; Hannoush, R. N.; Baran, P. S. "Scalable Total Synthesis and Biological Evaluation of Haouamine A and Its Atropisomer," J. Am. Chem. Soc. 2009, 131, 9172–9173.

Burns, N. Z.; Jessing, M.; Baran, P. S. "Total Synthesis of Haouamine A: the Indeno-Tetrahydropyridine Core," Tetrahedron, 2009, 65, 6600–6610.

Burns, N. Z.; Baran, P. S.; Hoffmann, R. W. "Redox Economy in Organic Synthesis," Angew. Chem., Int. Ed. 2009, 48, 2854–2867.

Burns, N. Z.; Baran, P. S. "On the Origin of the Haouamine Alkaloids," Angew. Chem., Int. Ed. 2008, 47, 205–208.

Baran, P. S.; Burns, N. Z. "Total Synthesis of (±)-Haouamine A," J. Am. Chem. Soc., 2006, 128, 3908–3909.

Burns, N. Z.; Hackman, B. H.; Ng, P. Y.; Powelson, I. A.; Leighton, J. L. "The Enantioselective Allylation and Crotylation of Sterically Hindered and Functionalized Aryl Ketones: Convenient Access to Unusual Tertiary Carbinol Structures," Angew. Chem., Int. Ed. 2006, 45, 3811–3813.




Noah Z. Burns
Assistant Professor

Stanford University
Department of Chemistry
333 Campus Drive
Stanford, CA 94305

335 Lorry Lokey Laboratory


nburns (at) stanford
Students interested in pursuing their graduate studies with us should apply to the Ph.D. program in chemistry:
graduate program application.
Postdoctoral applications should be mailed.