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PEOPLE


DIRECTORSHIP

DIRECTOR

Thomas A. Rando MD, PhD

The Rando laboratory is interested in the mechanisms of stem cell aging, including both systemic influences on stem cell function and intrinsic changes in stem cells with age. In those contexts, the laboratory studies experimental interventions to restore youthful function to aged stem cells. Of particular interest are transcriptional and epigenetic networks that define cellular age and how changes in those networks determine age-related declines in stem cell function. Studies in the Rando laboratory focus primarily on muscle stem cells but also stem cells in other lineages including fibrogenic, adipogenic, and neural lineages.

The Rando Laboratory at Stanford University

Stanford Medical School profile


ASSOCIATE DIRECTORS

Tony Wyss-Coray, PhD

The Wyss-Coray laboratory studies immune and injury responses in aging and neurodegeneration. A growing body of information in recent years has documented the interchangeability of key proteins between the immune and central nervous systems (CNS). One prominent example, and a focus of the lab, is TGF-β1 which is a key regulator of immune functions but is also necessary for neuronal protection and survival and may have a role in Alzheimer’s disease. Another group of proteins the lab is interested in constitutes the complement system, which is critical in the removal of pathogens and dying cells not only in the periphery, but likely in the CNS as well. In a less biased approach, the lab uses proteomics to study cellular communication on a larger scale in plasma and relate it to aging and degenerative changes in the CNS.

The Wyss-Coray Laboratory at Stanford University

Stanford Medical School profile

Anne Brunet, PhD

The Brunet laboratory studies the molecular basis of longevity. The Brunet laboratory is interested in the mechanism of action of known longevity genes, including FOXO transcription factors and SIRT deacetylases. The Brunet lab focuses on the role of these longevity genes in the mammalian nervous system, particularly in aging neural stem cells. The Brunet laboratory is also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.

The Brunet Laboratory at Stanford University

Stanford Medical School profile


AFFILIATED FACULTY

Andreasson, Katrin

Artandi, Steven

Attardi, Laura

Barres, Ben

Bassik, Michael

Bhutani, Nidhi

Blau, Helen

Butte, Atul

Chang, Ching-pin

Chang, Howard

Chen, Bertha

Chua, Katrin

Cimprich, Karlene

Covert, Markus

Dash, Rajesh

Davis, Mark

Dhabhar, Firdaus

Elias, Joshua

Feldman, Brian

Frydman, Judith

Gitler, Aaron D.

Goronzy, Jorg J.

Gozani, Or

Graef, Isabella

Greenleaf, William

Helms, Jill

Hu, Mickey

Huang, Kerwyn

Huang, Ting-Ting

Jarosz, Daniel

Kim, Seung

Kim, Stuart

Li, Jin Billy

Liao, Yaping

Longo, Frank

Lu, Bingwei

Meyer, Tobias

Mitchell, Beverly S.

Mochly-Rosen, Daria

Montgomery, Stephen

Palmer, Theo

Pritchard, John

Quake, Stephen

Reimer, Richard

Robinson, William

Sage, Julien

Sarnow, Peter

Schnitzer, Mark

Shatz, Carla

Shen, Kang

Shrager, Joseph

Snyder, Michael

Vollrath, Douglas

Wang, Xinnan

Weinberg, Kenneth

Weissman, Irv

Wernig, Marius

Weyand, Cornelia

Wu, Joseph

Wyss-Coray, Tony

Zolopa, Andrew