Thomas A. Rando MD, PhD
The Rando laboratory is interested in the mechanisms of stem cell aging, including both systemic influences on stem cell function and intrinsic changes in stem cells with age. In those contexts, the laboratory studies experimental interventions to restore youthful function to aged stem cells. Of particular interest are transcriptional and epigenetic networks that define cellular age and how changes in those networks determine age-related declines in stem cell function. Studies in the Rando laboratory focus primarily on muscle stem cells but also stem cells in other lineages including fibrogenic, adipogenic, and neural lineages.
Tony Wyss-Coray, PhD
The Wyss-Coray laboratory studies the role of immune and injury responses in neurodegeneration and Alzheimers disease. We seek to understand how immune responses and injury pathways may modulate neurodegeneration and age-related changes in the brain. We study these pathways in vivo and in cell culture using a number of genetic and proteomic tools. We have been particularly interested in the TGF-beta signaling pathway as a major regulator of biological processes and we are developing genetic and pharmacological agents to manipulate this pathway.
Anne Brunet, PhD
The Brunet laboratory studies the molecular basis of longevity. The Brunet laboratory is interested in the mechanism of action of known longevity genes, including FOXO transcription factors and SIRT deacetylases. The Brunet lab focuses on the role of these longevity genes in the mammalian nervous system, particularly in aging neural stem cells. The Brunet laboratory is also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.