Caulobacter crescentus is a premier model organism for studying
the molecular basis of cellular asymmetry.
The Caulobacter
community has generated a wealth of high-throughput spatiotemporal
databases including data from gene expression profiling
experiments (microarrays, RNA-seq, ChIP-seq, ribosome profiling,
LC-ms proteomics), gene essentiality studies (Tn-seq), genome wide
protein localization studies, and global chromosome methylation
(SMRT sequencing). A major challenge involves the integration of
these diverse datasets into one comprehensive community
resource.
To address this need, we have generated CauloBrowser, an
online resource for Caulobacter studies. This site provides a user-friendly interface for quickly
searching genes of interest and downloading genome-wide
results. Search results about individual genes are displayed as
tables, graphs of time resolved expression profiles, and
schematics of protein localization throughout the cell cycle. In
addition, the site provides a genome data browser that enables
customizable visualization of all published high-throughput
genomic data.
The depth and diversity of datasets collected by the
Caulobacter community makes CauloBrowser a unique and valuable
systems biology resource.
