PUBLICATIONS

2014

Pawel K. Mazur*, Nicolas Reynoird*, Purvesh Khatri, Pascal W.T.C. Jansen, Alex Wilkinson, Shichong Liu, Olena Barbash, Glenn S. Van Aller, Michael Huddleston, Dashyant Dhanak, Peter J. Tummino, Ryan G. Kruger, Benjamin Garcia, Atul J. Butte, Michiel Vermeulen, Julien Sage#, and Or Gozani# (2014). SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Nature, in press*These authors contributed equally to this work; #Equal correspondence

Moore KE and Gozani O.  An unexpected journey: Lysine methylation across the proteome. 2014. BBA, in press.

Wilkinson A and Gozani O. Histone-binding domains: Strategies for discovery and characterization. 2014. BBA, in press.

Martin GM, King DA, Green EM, Garcia-Nieto PE, Alexander R., Collins SR, Krogan NJ, Gozani O, and Morrison AJ.  Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons.  2014. Epigenetics, Jan 17;9(4)

Carlson SM, Moore KE, Green EM, Martin GM, and Gozani O.  Proteome-wide enrichment of proteins modified by lysine methylation.  2014. Nature Protocol. Jan;9(1):37-50, doi: 10.1038/nprot.2013.164

Or Gozani and Yang Shi, Chapter 5: Histone Methylation in Chromatin Signaling, Fundamentals of Chromatin, edited by Jerry Workman and Susan Abmayr, Springer Press, New York (2014)

2013

Bua DJ, Martin GM, Binda O, and Gozani O.  Nuclear phosphatidylinositol-5-phospate regulates ING2 stability at discrete chromatin targets in response to DNA damage. Sci Rep. 2013; 3:2137. doi: 10.1038/srep02137

Moore KE, Carlson SM, Camp ND, Cheung P, James RG, Chua KF, Wolf-Yadlin A, Gozani O. A General Molecular Affinity Strategy for Global Detection and Proteomic Analysis of Lysine Methylation. Mol Cell. 2013 Apr 9. doi:pii: S1097-2765(13)00209-8. 10.1016.

Paul S, Kuo A, Schalch T, Vogel H, Joshua-Tor L, McCombie WR, Gozani O, Hammell M, Mills AA. Chd5 requires PHD-mediated histone 3 binding for tumor suppression. Cell Rep. 2013 Jan 31;3(1):92-102. doi: 10.1016/j.celrep.2012.12.009. Epub 2013 Jan 10.

2012

Ballaré C, Lange M, Lapinaite A, Martin GM, Morey L, Pascual G, Liefke R, Simon B, Shi Y, Gozani O, Carlomagno T, Benitah SA, Di Croce L. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012 Dec;19(12):1257-65. doi: 10.1038/nsmb.2434. Epub 2012 Oct 28.

Price JV, Tangsombatvisit S, Xu G, Yu J, Levy D, Baechler EC, Gozani O, Varma M, Utz PJ, Liu CL. On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions. Nat Med. 2012 Sep;18(9):1434-40.

Green EM, Gozani O. Everybody’s welcome: The big tent approach to epigenetic drug discovery. Drug Discov Today Ther Strateg. 2012 Fall;9(2-3):e75-e81. Epub 2011 Sep 20.

Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A. Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY). 2012 Jul;4(7):462-79.

Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 2012 Jul 5;487(7405):114-8. doi: 10.1038/nature11043.

Green EM, Morrison AJ, Gozani O. New marks on the block: Set5 methylates H4 lysines 5, 8 and 12. Nucleus. 2012 Jul 1;3(4):335-9. Epub 2012 Jun 12.

Van Aller GS, Reynoird N, Barbash O, Huddleston M, Liu S, Zmoos AF, McDevitt P, Sinnamon R, Le B, Mas G, Annan R, Sage J, Garcia BA, Tummino PJ, Gozani O, Kruger RG. Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Epigenetics. 2012 Apr;7(4):340-3. doi: 10.4161/epi.19506. Epub 2012 Apr 1

Kuo AJ, Song J, Cheung P, Ishibe-Murakami S, Yamazoe S, Chen JK, Patel DJ, Gozani O.The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Nature. 2012 Mar 7. doi: 10.1038/nature10956.

Green EM, Mas G, Young NL, Garcia BA, Gozani O. Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Nat Struct Mol Biol. 2012 Feb 19;19(3):361-3. doi: 10.1038/nsmb.2252.

Liu CL, Tangsombatvisit S, Rosenberg JM, Mandelbaum G, Gillespie EC, Gozani OP, Alizadeh AA, Utz PJ. Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies. Arthritis Res Ther. 2012 Feb 2;14(1):R25.

2011

Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, Xi Y, Park BH, Shi X, Garcia BA, Li W, Gozani O. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell. 2011 Nov 18;44(4):609-20.

Levy D, Liu CL, Yang Z, Newman AM, Alizadeh AA, Utz PJ, Gozani O. A proteomic approach for the identification of novel lysine methyltransferase substrates. Epigenetics Chromatin. 2011 Oct 24;4:19

West LE, Gozani O. Regulation of p53 function by lysine methylation. Epigenomics. 2011 Jun;3(3):361-9

Lee JS, Kim Y, Bhin J, Shin HJ, Nam HJ, Lee SH, Yoon JB, Binda O, Gozani O, Hwang D, Baek SH . Hypoxia-induced methylation of a pontin chromatin remodeling factor. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13510-5

Green EM, Gozani O. CUL4B: trash talking at chromatin. Mol Cell. 2011 Aug 5;43(3):321-3.

Chang Y, Levy D, Horton JR, Peng J, Zhang X, Gozani O, Cheng X. Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Res. 2011 Aug;39(15):6380-9

Dan Levy, Alex J. Kuo, Yanqi Chang, Uwe Schaefer, Christopher Kitson, Peggie Cheung, Alexsandra Espejo, Barry M. Zee, Chih Long Liu, Stephanie Tangsombatvisit, Ruth I. Tennen, Andrew Y. Kuo, Song Tanjing, Regina Cheung, Katrin F. Chua, Paul J. Utz, Xiaobing Shi, Rab K. Prinjha, Kevin Lee, Benjamin A. Garcia, Mark T. Bedford, Alexander Tarakhovsky, Xiaodong Cheng and Or Gozani (2011). Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nature Immunology, 12(1):29-36.

Olivier Binda, Michael Boyce, Jason S. Rush, Krishnan K. Palaniappan, Carolyn R. Bertozzi, and Or Gozani (2011). A Chemical Method for Labeling Lysine Methyltransferase Substrates. ChemBioChem, doi: 10.1002/cbic.201000433.

2010

Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010 Dec 16;468(7326):927-32

Lisandra E. West, Siddhartha Roy, Karin Lachmi-Weiner, Ryo Hayashi, Xiaobing Shi, Ettore Appella, Tatiana G. Kutateladze#, and Or Gozani# (2010). The MBT repeats of L3MBTL1 link set8 mediated p53 methylation at lysine 382 to target gene repression. J. Biol. Chem. doi:10.1074/jbc.M110.139527; # equal correspondence

Louis A. Saddic, Lisandra E. West, Aaron Aslanian, John R. Yates, Seth M. Rubin, Or Gozani, and Julien Sage (2010). Methylation of the retinoblastoma tumor suppressor by SMYD2. J. Biol. Chem. doi:10.1074/jbc.M110.137612

Dan Levy and Or Gozani (2010). Decoding chromatin goes high tech. Cell, 17;142(6):844-6

Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O, Brunet A. (2010) Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature; 466(7304):383-7.

Kleine-Kohlbrecher D, Christensen J, Vandamme J, Abarrategui I, Bak M, Tommerup N, Shi X, Gozani O, Rappsilber J, Salcini AE, Helin K (2010). A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation. Molecular Cell. 23;38(2):165-78.

Chang PY, Hom RA, Musselman CA, Zhu L, Kuo A, Gozani O, Kutateladze TG, Cleary ML (2010). Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription. J Mol Biol, 400(2):137-44.

Hom RA, Chang PY, Roy S, Musselman CA, Glass KC, Selezneva AI, Gozani O, Ismagilov RF, Cleary ML, Kutateladze TG (2010). Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J Mol Biol;400(2):145-54.

Lee JS, Kim Y, Kim IS, Kim B, Choi HJ, Lee JM, Shin HJ, Kim JH, Kim JY, Seo SB, Lee H, Binda O, Gozani O, Semenza GL, Kim M, Kim KI, Hwang D, Baek SH (2010). Negative regulation of hypoxic responses via induced Reptin methylation. Mol Cell; 39(1):71-85.

Roy S, Musselman CA, Kachirskaia I, Hayashi R, Glass KC, Nix JC, Gozani O, Appella E, Kutateladze TG (2010). Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biol. 14;398(4):489-96.

2009

Dennis J. Bua, Alex J. Kuo, Peggie Cheung, Chih Long Liu, Valentina Migliori, Alexsandra Espejo, Fabio Casadio, Christian Bassi, Bruno Amati, Mark T. Bedford, Ernesto Guccione, and Or Gozani. (2009) Epigenome Microarray Platform for Proteome-Wide Dissection of Chromatin-Signaling Networks. PLoS ONE 4(8): e6789. doi:10.1371/journal.pone.0006789 [Full Text PDF]

Michishita E, McCord RA, Boxer LD, Barber MF, Hong T, Gozani O, Chua KF (2009).  Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Cell Cycle.8(16):2664-6. [Full Text PDF]

Li Y, Trojer P, Xu CF, Cheung P, Kuo A, Drury WJ 3rd, Qiao Q, Neubert TA, Xu RM, Gozani O, Reinberg D (2009). The target of the NSD family of histone lysine methyl transferases depends on the nature of the substrate.  J Biol Chem, 284, 34283-34295. [Full Text PDF]

McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, and Chua KF (2009). SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair. Aging 1: 109-121. [Full Text PDF]

Nehmé Saksouk, Nikita Avvakumov ,Karen S. Champagne, Tiffany Hung, Yannick Doyon, Christelle Cayrou, Eric Paquet, Mukta Ullah, Anne-Julie Landry, Valérie Côté, Xiang-Jiao Yang, Or Gozani, Tatiana G. Kutateladze and Jacques Côté. (2009) HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail.  Molecular Cell, 33(2): 257-265. [Full Text PDF]

Tiffany Hung, Olivier Binda, Karen S. Champagne, Alex J. Kuo, Kyle Johnson, Howard Y. Chang, Matthew D. Simon, Tatiana G. Kutateladze and Or Gozani (2009).  ING4 mediates crosstalk between histone H3K4 trimethylation and H3 acetylation to attenuate cellular transformation.  Molecular Cell, 33(2): 248-256. [Full Text PDF]

2008

Pedro V. Peña, Catherine A. Musselman, Alex J. Kuo, William P. Schiemann, Or Gozani, and Tatiana G. Kutateladze (2008). NMR assignments and histone specificity of the ING2 PHD.  Magnetic Resonance in Chemistry, 47(4): 352–358. [Full Text PDF]

Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, and D. Mathis (2008).  Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.  Proc Natl Acad Sci, 105(41): 15878-83.[Full Text PDF]

Kachirskaia I, Shi X, Yamaguchi H, Tanoue K, Wen H, Wang EW, Appella E, and O. Gozani (2008).  Role for 53BP1 tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling.  Journal of Biological Chemistry, 283(50):34660-6.[Full Text PDF]

Peña PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RP, Subach OM, Champagne KS, Zhao R, Verkhusha VV, Li G, Gozani O, and TG Kutateladze (2008).  Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J Mol Biol, 380(2):303-12. [Full Text PDF]

Michishita, E., McCord, R.A., Berber E., Kioi, M., Padilla-Nash, H,, Damian, M., Cheung, P., Kusomoto, R., Kawahara, T.L.A., Barrett, J.C., Chang, H.Y., Bohr, V.A., Ried, T., Gozani, O. and K.F. Chua (2008). SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature, 452(7186):492-6.[Full Text PDF]

2007

Adam G. W. Matthews*, Alex J. Kuo*, Santiago Ramon-Maiques, Sunmi Han, Karen S. Champagne, Dmitri Ivanov, Mercedes Gallardo, Dylan Carney, Peggie Cheung, David N. Ciccone, Kay L. Walter, Paul J. Utz, Yang Shi, Tatiana G. Kutateladze, Wei Yang, Or Gozani# & Marjorie A. Oettinger# (2007). RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature, 450(7172):1106-10. [Full Text PDF]
*These authors contributed equally to this work
#Equal correspondence

Santiago Ramon-Maiques, Alex J. Kuo, Dylan Carney, Adam G. W. Matthews, Marjorie A. Oettinger, Or Gozani, and Wei Yang (2007). The PHD finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. PNAS, 104(48):18993-8. [Full Text PDF]

Shi, X., Kachirskaia, I., Yamaguchi, H., West, L.E., Wen, H., Wang, E.W., Dutta, S., Appella, E. and Or Gozani (2007). Modulation of p53 function by SET8-mediated methylation at lysine 382. Molecular Cell, 27: 636-646.[Full Text PDF]

Huang, W., Zhang, H., Davrazou, F., Kutateladze, T.G., Shi, X., Gozani, O. and G.D. Prestwich (2007). Stabilized Phosphatidylinositol-5-Phosphate Analogues as Ligands for the Nuclear Protein ING2: Chemistry, Biology and Molecular Modeling.  JACS 129(20):6498-506.[Full Text PDF]

Shi, X., Kachirskaia, I., Walter K.L., Kuo, J.H., Lake A., Davrazou, F., Chan, S.M., Martin, D.G., Fingerman, I.M., Briggs, S.D., Howe, L., Utz, P.J., Kutateladze, T.G., Lugovskoy, A.A., Bedford, M.T., and O. Gozani (2007). Proteome-wide analysis in S. cerevisae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. JBC, 282, 2450-2455.[Full Text PDF]

2006

David G. E. Martin, Kristin Baetz, Xiaobing Shi, Kay L. Walter, Vicki E. MacDonald, Martin J. Wlodarski, Or Gozani, Philip Hieter, and LeAnn Howe (2006). The Yng1p Plant Homeodomain Finger Is a Methyl-Histone Binding Module That Recognizes Lysine 4-Methylated Histone H3. MCB, 26: 7871-7879.[Full Text PDF]

Xiaobing Shi, Tao Hong, Kay L. Walter, Mark Ewalt, Eriko Michishita, Tiffany Hung, Dylan Carney, Pedro Peña, Fei Lan, Mohan R. Kaadige, Nicolas Lacoste, Christelle Cayrou Foteini Davrazou, Anjanabha Saha, Bradley R. Cairns, Donald E. Ayer, Tatiana G. Kutateladze, Yang Shi, Jacques Côté, Katrin F. Chua, and Or Gozani (2006). ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature, 442, 96-99. [Full Text PDF]

Pedro V. Peña, Foteini Davrazou, Xiaobing Shi, Kay L. Walter, Vladislav V. Verkhusha, Or Gozani, Rui Zhao and Tatiana G. Kutateladze (2006). Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.  Nature, 442, 100-103. [Full Text PDF]

Caroline Pendaries, Hélène Tronchère, Laurence Arbibe, Joelle Mounier, Or Gozani, Lewis Cantley, Michael J Fry, Frédérique Gaits-Iacovoni, Philippe J Sansonetti and Bernard Payrastre (2006).  PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.  The EMBO Journal,  25: 1024–1034.[Full Text PDF]

2005

Xiaobing Shi and Or Gozani (2005). The Fellowships of the INGs.  Journal of Cellular Biochemistry, 96(6): 1127-1136.[Full Text PDF]

Sheryl K. Elkin, Dmitri Ivanov, Mark Ewalt, Colin G. Ferguson, Sven G. Hyberts, Zhen-Yu J. Sun, Glenn D. Prestwich, Junying Yuan, Gerhard Wagner, Marjorie A. Oettinger, Or Gozani (2005). A PHD finger motif in the C-terminus of RAG2 modulates recombination activity. JBC, 280(31): 28701-10.[Full Text PDF]