All Posts In Drugs and Supplements

Prion-like Behavior in the Huntingtin Protein

Prion-Like Behavior in the Huntingtin Protein: Protein aggregates are a hallmark feature of Huntington’s disease (HD)[1], as well as a number of other neurodegenerative diseases. These protein aggregates, composed of misfolded proteins that clump together, are traditionally thought to develop in vulnerable neurons individually. However, recent research suggests that these misfolded proteins may be transmitted […]

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Drugs and Supplements: Table of Contents

Antisense gene therapy Brain-derived neurotrophic factor (BDNF) Carnitine Caspase-6 inhibition Chelation therapy Coenzyme Q10 Creatine Cystamine Dichloroacetate Dimebon Ethyl-EPA (Miraxion, LAX-101) Fluoxetine Folic Acid Geldanamycin Ginkgo Biloba Glucocorticoids HDAC Inhibitors Lamotrigine Lipoic Acid Lithium Memantine Minocycline Mithramycin Neurotrophic factors Neurturin Nicotinamide Non-steroidal Anti-inflammatory Drugs (NSAIDs) Aspirin Acetaminophen Ibuprofen Omega-3 Fatty Acids EPA (LAX-101) DHA Paroxetine […]

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TRiC and Huntingtin Protein Aggregation

In Huntington’s disease (HD), an abnormal increase in the number of CAG repeats in the mutant Huntington gene corresponds to a long tract of glutamine amino acids in the huntingtin protein (Htt). This excessively long glutamine tract is sticky and leads to the formation of protein aggregates in brain cells. Whether these aggregates are toxic […]

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Genome Editing

Although the pathology of Huntington’s disease (HD) is still not completely understood, we know that HD is a genetic disorder where the root cause of every HD case is a longer-than-normal series of three repeated DNA base pairs, CAG, in the HD gene. A DNA sequence provides the instructions for the cell to make mRNA […]

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Gangliosides

Contrary to what one may think, the brain is the most fat-rich organ in the body.  Aside from being an efficient way to store energy from the food we eat, fat molecules, known as lipids, have many variations in their structure, allowing for a correspondingly large number of additional functions.  For example, some lipids are […]

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Vitamin D3 (cholecalciferol)

Vitamin D has been called the “miracle vitamin” by many health experts due to mounting discoveries of its significance in promoting health and fighting numerous diseases, including cancer, heart disease, and diabetes. It may also be therapeutic for neurodegenerative diseases, which may be relevant to Huntington’s disease (HD). This particular vitamin is found in many […]

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Melatonin

It has long been known that melatonin, a hormone produced in the brain, plays an important role in regulating the body’s natural sleep-wake cycle by causing drowsiness and inducing sleep. The pineal gland, a small structure located beneath the center of the brain produces and releases melatonin in response to the intensity and type of […]

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Gene Silencing

Huntington’s disease (HD) is a genetic disease due to the abnormal CAG expansion of the mutated huntingtin gene.  The mutated gene instructs cells in the body to produce a version of the huntingtin protein that ultimately leads to neuronal damage in the brain and creates the symptoms of HD.  Currently, available HD therapies can only […]

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Retinoic Acid (RA)

Recent research has spotlighted retinoic acid (RA) as an intriguing possibility for further exploration as a treatment for Huntington’s disease.  Retinoic acid is derived from a compound that we know as Vitamin A, which is fat-soluble and primarily found in two forms: retinol and carotenoids.  Retinoic acid is synthesized in the body from retinol, which […]

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Pridopidine (Huntexil, ACR-16)

Drug Summary: Pridopidine, also known as Huntexil or ACR-16, is a dopamine stabilizer intended to improve voluntary movements and reduce chorea. Initial clinical trials – the MermaiHD and HART studies – show promising results, but drug regulation agencies have requested another trial before pridopidine can be sold to the general public. control relevant M. Hedlin, […]

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About Disease Mechanisms

Welcome to the "Drugs and Supplements" section of the HOPES website! Articles within this section will frequently use the terms "treatment" and "cure." Please note, though, that the word "treatment" must not be confused with the word "cure," for there is currently no medical cure for Huntington's Disease (HD).

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About Huntington’s Disease and Serotonin

Serotonin (also known as 5-HT) is a neurotransmitter used to communicate important information between nerve cells. Serotonin is sometimes referred to as the “feel good” neurotransmitter owing to its association with elevated mood levels. It also has many other functions in the central nervous system including roles in sleep, depression, memory, pain, and aggression. Recent […]

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About Free Radical Damage

Aside from impaired energy production, damage to the mitochondria leads also to increased production of toxic molecules called free radicals. Compounds called antioxidants act as free radical scavengers by initiating reactions that make free radicals non-toxic to cells. Evidence indicates that damage by free radicals is a contributing factor to the pathology of HD. Consequently, […]

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