Proteins undergo an ongoing cycle of being folded and unfolded. This is caused by various changes in the protein’s environment. When a protein becomes unfolded or misfolded, if not folded back correctly, they may possibly join up with other unfolded or misfolded proteins. This group of misfolded proteins is what is known as a protein aggregate, and the process is known as protein aggregation. It is possible that protein aggregation plays a role in the development of HD.