Arches. Photo by Daniel Chia
HOPES: Huntington's Outreach Project for Education, at Stanford
Jun
26
2011

About Inflammation

Inflammation, what we commonly know as the swelling, redness, heat, and pain that often accompany injuries, is one of our body’s most important natural defense mechanisms against internal and external threats. The inflammatory process protects our body from damage and disease by releasing cells and mediators that combat foreign substances and help prevent infection. However, [...]

Jun
29
2010

Folic Acid

Drug Summary: Folic acid, also known as vitamin B11 and naturally found in the form of folate, is important in many biological processes. A recent study conducted over three years with healthy adults 50-70 years old showed that folic acid supplements equal to twice the recommended daily value improved memory and slowed decline in muscle [...]

Jun
29
2010

Minocycline

Update: a 2010 study of Minocycline, called DOMINO, concluded that minocycline does not warrant further study for the treatment of HD. 114 patients who had mild to moderate HD were treated with either 200 mg of minocycline or a placebo every day for 18 months. The study measured patient’s improvement in the Total Functional Capacity [...]

Jun
29
2010

Omega-3 Fatty Acids

Drug Summary: Omega-3 fatty acids are a form of fatty acids that our body derives from food. Studies have discovered that omega-3 fatty acids have anti-inflammatory effects due to their ability to convert into anti-inflammatory prostaglandins. In addition, omega-3 fatty acids can decrease the production of inflammatory prostaglandins, resulting in a greater decrease in inflammation. [...]

Jun
29
2010

NSAIDs

Drug Summary: NSAIDs (Non-steroidal anti-inflammatory drugs) are compounds that significantly reduce the inflammatory response. Common examples of NSAIDs include ibuprofen (Motrin®, Advil®) and naproxen (Aleve®). Studies have shown that chronic inflammatory responses occur in vulnerable areas of the brains of HD patients. These inflammatory responses are believed to be a contributing factor to the death [...]

Jun
29
2010

Glucocorticoids

Drug Summary: Glucocorticoids are powerful anti-inflammatory compounds that have the ability to inhibit all stages of the inflammatory response. Common glucocorticoids include prednisone, dexamethasone, and hydrocortisone. While glucocorticoids are widely used as drugs to treat various inflammatory conditions, prolonged glucocorticoid use may have adverse side effects such as immunosuppression, fluid shifts, brain changes, and psychological [...]