Arches. Photo by Daniel Chia
HOPES: Huntington's Outreach Project for Education, at Stanford
Aug
27
2014

Emotional Recognition Deficits

It is well documented, as reviewed by Labuschagne et al. (2012), that Huntington’s disease (HD) patients often have difficulty recognizing facial cues and understanding emotions of other individuals1, especially regarding the emotion of disgust2. Such emotional deficits can greatly diminish their ability to communicate, which may result in aggravated tension and stress between patients and [...]

Dec
06
2013

Trojan Therapy

The blood-brain barrier (BBB) is a layer of cells that block most molecules from entering the brain in order to protect this sensitive organ from external invaders. It does its job so well that delivering treatments to the brain is extremely difficult and poses a great challenge to drug development. Researchers from the University of [...]

May
22
2013

Transgenic HD Monkey Models

Introduction This article will discuss the advantages and disadvantages of using transgenic monkeys to model Huntington’s disease (HD). Most HD animal research utilizes mouse models of the disease. While there is much that we can learn from mice, animals that are more similar to humans, such as monkeys, could offer more pertinent insights into HD [...]

Dec
10
2012

Huntington Study Group’s Huntington’s Disease Clinical Research Symposium 2012

Saturday, November 10, 2012, marked the sixth annual Huntington’s Disease Clinical Research Symposium in Seattle, Washington. This event, organized by the Huntington Study Group, was open to the public and provided an opportunity for attendees to learn about the latest in clinical research and trials. Print PDF

May
02
2012

University of California at San Francisco 2012 HD Research Symposium

Saturday, February 11, 2011, marked the ninth-annual HD research symposium at the University of California at San Francisco. The UCSF Memory and Aging Center and the HDSA Center of Excellence at UC Davis Medical Center partnered to present this free public conference where attendees could learn the latest in HD research.

Several HOPES members appeared at the event. This page gives a summary of the presentations they heard.

Apr
09
2012

Neuroimaging

Neuroimaging refers to techniques that produce images of the brain without requiring surgery, incision of the skin, or any direct contact with the inside of the body.  Because these technologies enable noninvasive visualization of the structure and functionality of the brain, neuroimaging has become a powerful tool for both research and medical diagnosis.  Although still [...]

Nov
16
2011

Weight Loss: Demystifying a Medical Mystery

While Huntington’s disease is traditionally thought of as a disease of the brain, its effects are much more widespread: many people with HD lose a dangerous amount of weight, complicating a disease that is already complicated enough. Although weight loss is one of the most serious non-neurological problems of HD, scientists don’t fully understand why [...]

Jul
30
2011

“Normal” huntingtin and Huntington’s disease

Since the Huntington’s Study Group first identified the mutation responsible for Huntington’s disease (HD) in 1993, there have been many studies conducted seeking to understand how this defective gene causes the drastic neurodegeneration seen in individuals with HD. It is known that the expansion of CAG repeats in the Huntington gene results in a misfolded [...]

Jul
30
2011

University of California at San Francisco 2010 HD Research Symposium

HOPES summary of the talks from scientists and clinicians Note: This article includes references to Dimebon, which is no longer being considered as a potential treatment for HD after the HORIZON clinical trial showed that Dimebon was not better than a placebo. For more information, click here F. Clum, C. Garnett, T. Wang and A, [...]

Jul
28
2011

Induced Pluripotent Stem Cells: The Future of Tissue Generation

As viable human brain tissue is not available for use in studying disease development and creating therapies for neurological disorders like Huntington’s disease (HD), researchers desperately needed an alternative cell source for this purpose.  Embryonic stem cells fit this role but have many disadvantages, especially for treatments, including immune rejection by the recipient. Some of [...]