Arches. Photo by Daniel Chia
HOPES: Huntington's Outreach Project for Education, at Stanford

repressor element 1/neuron restrictive silencing element (RE1/NRSE)

a region of DNA that is recognized and bound by a transcription factor called repressor element 1/neuronal restrictive silencing transcription factor (REST/NSRF). This binding of REST/NSRF to RE1/NSRE inhibits the gene downstream. The RE1/NSRE sequence is found before many genes, including BDNF.