PUBLICATIONS

 

2005-PRESENT
Tennen RI, Chua KF. "Chromatin regulation and genome maintenance by mammalian SIRT6." Trends Biochem Sci. 2010.

Tennen RI, Berber E, Chua KF. "Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization." Mech Ageing Dev. 2010; 131 (3): 185-92.

Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, Chua KF. "SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span." Cell. 2009; 136 (1): 62-74

Michishita E, McCord RA, Boxer LD, Barber MF, Hong T, Gozani O, Chua KF."Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6." Cell Cycle. 2009; 8 (16): 2664-6

McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, and Chua KF. "SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair." Aging 2009; 1: 109-121.

Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P. "Mice lacking HDAC6 have hyperacetylated tubulin but are viable and develop normally." Mol Cell Biol 2008;28,1688-701.

Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF. "SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin." Nature 2008; 452: 7186: 492-6.

Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. "Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6." Cell 2006; 124: 2: 315-29.

Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Peña P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Côté J, Chua KF, Gozani O. "ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression." Nature 2006; 442, 96-99.
 

BEFORE 2005
Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW. "Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress." Cell Metab 2005; 2: 1: 67-76.
 
Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW. "DNA repair, genome stability, and aging." Cell 2005; 120: 4: 497-512.

Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME "Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase." Science 2004; 303: 5666: 2011-5.

Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF. "Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice." Proc Natl Acad Sci U S A 2003; 100: 19: 10794-9.

Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW. "Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors." Cell 2003; 114: 3: 359-70.

Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW. "Transcription-targeted DNA deamination by the AID antibody diversification enzyme." Nature 2003; 422: 6933: 726-30.
 
Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW. "The influence of transcriptional orientation on endogenous switch region function." Nat Immunol 2003; 4: 5: 435-41.
 
Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW. "Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX." Proc Natl Acad Sci U S A 2002; 99: 12: 8173-8.

Chua KF, Alt FW, Manis JP "The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks." J Exp Med 2002; 195: 9: F37-41.

Chua K, Reed R. "An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing." Mol Cell Biol 2001; 21: 5: 1509-14.

Chua K, Reed R. "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice." Nature 1999; 402: 6758: 207-10.

Chua K, Reed R. "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing." Genes Dev 1999; 13: 7: 841-50.

Seghezzi W, Chua K, Shanahan F, Gozani O, Reed R, Lees E. "Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cells." Mol Cell Biol 1998; 18: 8: 4526-36.

Wang C, Chua K, Seghezzi W, Lees E, Gozani O, Reed R. "Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis." Genes Dev 1998; 12: 10: 1409-14.

Berglund JA, Chua K, Abovich N, Reed R, Rosbash M. "The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC." Cell 1997; 89: 5: 781-7.