Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodeling [PubMed]
Gomes KM(1), Campos JC, Bechara LR, Queliconi B, Lima VM, Disatnik MH, Magno P, Chen CH, Brum PC, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC
Cardiovasc Res. 2014 May 9. [Epub ahead of print]
Development of Selective Inhibitors for Aldehyde Dehydrogenases based on Substituted Indole-2,3-diones [PubMed]
Kimble-Hill AC, Parajuli B, Chen CH, Mochly-Rosen D, Hurley TD
J Med Chem. 2014 Jan 20. [Epub ahead of print]
The challenge in translating basic research discoveries to treatment of Huntington disease [PubMed]
Mochly-Rosen D(1), Disatnik MH(1), Qi X(2)
Rare Dis. 2014 Mar 31;2:e28637. doi: 10.4161/rdis.28637. eCollection 2014
Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats [PubMed]
Zambelli VO(1), Fernandes AC(1), Gutierrez VP(1), Ferreira JC(2), Parada CA(3), Mochly-Rosen D(4), Cury Y(1)
PLoS One. 2014 Mar 4;9(3):e90576. doi: 10.1371/journal.pone.0090576. eCollection 2014
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities [PubMed]
Chen CH, Ferreira JC, Gross ER, Mochly-Rosen D
Physiol Rev. 2014 Jan;94(1):1-34. doi: 10.1152/physrev.00017.2013
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration [PubMed]
Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X
J Clin Invest. 2013 Nov 15. pii: 70911. doi: 10.1172/JCI70911. [Epub ahead of print]
Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction [PubMed]
Disatnik MH, Ferreira JC, Campos JC, Gomes KS, Dourado PM, Qi X, Mochly-Rosen D
J Am Heart Assoc. 2013 Oct 8;2(5):e000461. doi: 10.1161/JAHA.113.000461
Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C [PubMed]
Gross ER, Hsu AK, Urban TJ, Mochly-Rosen D, Gross GJ
Basic Res Cardiol. 2013 Sep;108(5):381. doi: 10.1007/s00395-013-0381-x. Epub 2013 Aug 28
A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth [PubMed]
Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT
Clin Cancer Res. 2013 Aug 15;19(16):4455-64. doi: 10.1158/1078-0432.CCR-13-0127. Epub 2013 Jun 28
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cδ (PKCδ) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury [PubMed]
Yogalingam G, Hwang S, Ferreira JC, Mochly-Rosen D
J Biol Chem. 2013 Jun 28;288(26):18947-60. doi: 10.1074/jbc.M113.466870. Epub 2013 May 7
Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis [PubMed]
Solito R, Corti F, Chen CH, Mochly-Rosen D, Giachetti A, Ziche M, Donnini S
J Cell Sci. 2013 May 1;126(Pt 9):1952-61. doi: 10.1242/jcs.117184. Epub 2013 Feb 27
Translational medicine: mitigating risks for investigators [PubMed]
Mann DL, Mochly-Rosen D
Nat Rev Drug Discov. 2013 May;12(5):327-8. doi: 10.1038/nrd4005
In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate [PubMed]
Josan S, Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D
NMR Biomed. 2013 Jun;26(6):607-12. doi: 10.1002/nbm.2897. Epub 2012 Dec 6
Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice [PubMed]
Sun X, Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG
J Neurosci Res. 2013 Jun;91(6):799-807. doi: 10.1002/jnr.23186. Epub 2013 Feb 21
Focus on: the cardiovascular system: what did we learn from the French (paradox)? [PubMed]
Mochly-Rosen D, Zakhari S
Alcohol Res Health. 2010;33(1):76-86
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity [PubMed]
Qi X, Qvit N, Su YC, Mochly-Rosen D
J Cell Sci. 2013 Feb 1;126(Pt 3):789-802. doi: 10.1242/jcs.114439. Epub 2012 Dec 13
Exercise training restores cardiac protein quality control in heart failure [PubMed]
Campos JC, Queliconi BB, Dourado PM, Cunha TF, Zambelli VO, Bechara LR, Kowaltowski AJ, Brum PC, Mochly-Rosen D, Ferreira JC
PLoS One. 2012;7(12):e52764. doi: 10.1371/journal.pone.0052764. Epub 2012 Dec 27
Protein kinase C, an elusive therapeutic target? [PubMed]
Mochly-Rosen D, Das K, Grimes KV
Nat Rev Drug Discov. 2012 Dec;11(12):937-57. doi: 10.1038/nrd3871
Activation of εPKC reduces reperfusion arrhythmias and improves recovery from ischemia: optical mapping of activation patterns in the isolated guinea-pig heart [PubMed]
Restivo M, Kozhevnikov DO, Qu YS, Yue Y, Mochly-Rosen D, El-Sherif N, Boutjdir M
Biochem Biophys Res Commun. 2012 Sep 21;426(2):237-41. doi: 10.1016/j.bbrc.2012.08.073. Epub 2012 Aug 22
Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption [PubMed]
Chang YC, Chiu YF, Lee IT, Ho LT, Hung YJ, Hsiung CA, Quertermous T, Donlon T, Lee WJ, Lee PC, Chen CH, Mochly-Rosen D, Chuang LM
BMC Cardiovasc Disord. 2012 Jul 29;12:58
Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice [PubMed]
Ning S, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D
Radiat Res. 2012 Jul;178(1):69-74. Epub 2012 Mar 9
Identification of εPKC targets during cardiac ischemic injury [PubMed]
Budas G, Costa HM Jr, Ferreira JC, Teixeira da Silva Ferreira A, Perales J, Krieger JE, Mochly-Rosen D, Schechtman D
Circ J. 2012;76(6):1476-85. Epub 2012 Mar 27
Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes [PubMed]
Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG
Oncogene. 2012 May 17;31(20):2593-600. doi: 10.1038/onc.2011.428. Epub 2011 Sep 26
Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3 [PubMed]
Ferreira JC, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D
PLoS One. 2012;7(3):e33175. doi: 10.1371/journal.pone.0033175. Epub 2012 Mar 30
Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure [PubMed]
Qvit N, Mochly-Rosen D
Drug Discov Today Dis Mech. 2010 Summer;7(2):e87-e93
Regulation of mitochondrial processes: a target for heart failure [PubMed]
Palaniyandi SS, Qi X, Yogalingam G, Ferreira JC, Mochly-Rosen D
Drug Discov Today Dis Mech. 2010 Summer;7(2):e95-e102
Regulation of cardiac excitability by protein kinase C isozymes [PubMed]
Ferreira JC, Mochly-Rosen D, Boutjdir M
Front Biosci (Schol Ed). 2012 Jan 1;4:532-46
Nitroglycerin use in myocardial infarction patients [PubMed]
Ferreira JC, Mochly-Rosen D
Circ J. 2012;76(1):15-21. Epub 2011 Nov 1
Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases [PubMed]
Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD
J Biol Chem. 2011 Dec 16;286(50):43486-94. doi: 10.1074/jbc.M111.293597. Epub 2011 Oct 21
A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo [PubMed]
Banh A, Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, Koong AC, Le QT
Clin Cancer Res. 2011 Dec 1;17(23):7265-72. doi: 10.1158/1078-0432.CCR-11-0179. Epub 2011 Oct 13
Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy [PubMed]
Ferreira JC, Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D
J Mol Cell Cardiol. 2011 Dec;51(6):980-7. doi: 10.1016/j.yjmcc.2011.08.025. Epub 2011 Sep 2
ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance [PubMed]
Sun L, Ferreira JC, Mochly-Rosen D
Sci Transl Med. 2011 Nov 2;3(107):107ra111. doi: 10.1126/scitranslmed.3002067
β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways [PubMed]
Fajardo G, Zhao M, Berry G, Wong LJ, Mochly-Rosen D, Bernstein D
J Mol Cell Cardiol. 2011 Nov;51(5):781-9. doi: 10.1016/j.yjmcc.2011.06.019. Epub 2011 Jul 2
Myocardial salvage in acute myocardial infarction--challenges in clinical translation [PubMed]
Mochly-Rosen D, Grimes KV
J Mol Cell Cardiol. 2011 Oct;51(4):451-3. doi: 10.1016/j.yjmcc.2011.08.002. Epub 2011 Aug 12
βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure [PubMed]
Ferreira JC, Brum PC, Mochly-Rosen D
J Mol Cell Cardiol. 2011 Oct;51(4):479-84. doi: 10.1016/j.yjmcc.2010.10.020. Epub 2010 Oct 28
PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses [PubMed]
Palaniyandi SS, Ferreira JC, Brum PC, Mochly-Rosen D
J Cell Mol Med. 2011 Aug;15(8):1769-77. doi: 10.1111/j.1582-4934.2010.01174.x
Therapeutic potential for protein kinase C inhibitor in vascular restenosis [PubMed]
Ding RQ, Tsao J, Chai H, Mochly-Rosen D, Zhou W
J Cardiovasc Pharmacol Ther. 2011 Jun;16(2):160-7. doi: 10.1177/1074248410382106. Epub 2010 Dec 23
PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells [PubMed]
Kim J, Koyanagi T, Mochly-Rosen D
Prostate. 2011 Jun 15;71(9):946-54. doi: 10.1002/pros.21310. Epub 2010 Nov 23
Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells [PubMed]
Ding Q, Chai H, Mahmood N, Tsao J, Mochly-Rosen D, Zhou W
J Vasc Surg. 2011 Apr;53(4):1044-51. doi: 10.1016/j.jvs.2010.10.117. Epub 2011 Jan 31
Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo [PubMed]
Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D
Mol Biol Cell. 2011 Jan 15;22(2):256-65. doi: 10.1091/mbc.E10-06-0551. Epub 2010 Nov 30
Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting [PubMed]
Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S
Circulation. 2010 Sep 14;122(11 Suppl):S170-8. doi: 10.1161/CIRCULATIONAHA.109.927640
Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury [PubMed]
Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D
Cardiovasc Res. 2010 Oct 1;88(1):83-92. doi: 10.1093/cvr/cvq154. Epub 2010 Jun 16
Mitochondrial aldehyde dehydrogenase and cardiac diseases [PubMed]
Chen CH, Sun L, Mochly-Rosen D
Cardiovasc Res. 2010 Oct 1;88(1):51-7. doi: 10.1093/cvr/cvq192. Epub 2010 Jun 16
Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells [PubMed]
Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R
Circulation. 2010 Aug 24;122(8):771-81. doi: 10.1161/CIRCULATIONAHA.110.952481. Epub 2010 Aug 9
Non-volume-loaded heart provides a more relevant heterotopic transplantation model [PubMed]
Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S
Transpl Immunol. 2010 May;23(1-2):65-70. doi: 10.1016/j.trim.2010.04.005. Epub 2010 Apr 18
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification [PubMed]
Monti M, Donnini S, Giachetti A, Mochly-Rosen D, Ziche M
J Mol Cell Cardiol. 2010 Apr;48(4):746-56. doi: 10.1016/j.yjmcc.2009.11.002. Epub 2009 Nov 11
Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice [PubMed]
Budas GR, Disatnik MH, Chen CH, Mochly-Rosen D
J Mol Cell Cardiol. 2010 Apr;48(4):757-64. doi: 10.1016/j.yjmcc.2009.10.030. Epub 2009 Nov 11
Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant [PubMed]
Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD
Nat Struct Mol Biol. 2010 Feb;17(2):159-64. doi: 10.1038/nsmb.1737. Epub 2010 Jan 10
Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion [PubMed]
Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D
Cardiovasc Res. 2010 Jan 15;85(2):385-94. doi: 10.1093/cvr/cvp334. Epub 2009 Oct 10
Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? [PubMed]
Budas GR, Disatnik MH, Mochly-Rosen D
Trends Cardiovasc Med. 2009 Jul;19(5):158-64. doi: 10.1016/j.tcm.2009.09.003
Protein kinase C in heart failure: a therapeutic target? [PubMed]
Palaniyandi SS, Sun L, Ferreira JC, Mochly-Rosen D
Cardiovasc Res. 2009 May 1;82(2):229-39. doi: 10.1093/cvr/cvp001. Epub 2009 Jan 24
Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model [PubMed]
Kaneda H, Ikeno F, Inagaki K, Mochly-Rosen D
Int J Cardiol. 2009 Apr 3;133(2):256-9. doi: 10.1016/j.ijcard.2007.11.021. Epub 2008 Feb 1
Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats [PubMed]
Castañeda D, Zhao H, Mochly-Rosen D, Steinberg GK
Brain Res. 2009 Jan 28;1251:256-61. doi: 10.1016/j.brainres.2008.11.051. Epub 2008 Nov 27
Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2 [PubMed]
Churchill EN, Disatnik MH, Mochly-Rosen D
J Mol Cell Cardiol. 2009 Feb;46(2):278-84. doi: 10.1016/j.yjmcc.2008.09.713. Epub 2008 Oct 17
Rationally designed peptide regulators of protein kinase C [PubMed]
Churchill EN, Qvit N, Mochly-Rosen D
Trends Endocrinol Metab. 2009 Jan;20(1):25-33. doi: 10.1016/j.tem.2008.10.002. Epub 2008 Dec 4
Ethanol for cardiac ischemia: the role of protein kinase c [PubMed]
Churchill EN, Disatnik MH, Budas GR, Mochly-Rosen D
Ther Adv Cardiovasc Dis. 2008 Dec;2(6):469-83. doi: 10.1177/1753944708094735
Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure [PubMed]
Palaniyandi SS, Inagaki K, Mochly-Rosen D
J Mol Cell Cardiol. 2008 Dec;45(6):779-86. doi: 10.1016/j.yjmcc.2008.08.009. Epub 2008 Sep 4
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart [PubMed]
Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D
Science. 2008 Sep 12;321(5895):1493-5. doi: 10.1126/science.1158554
Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis [PubMed]
Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D
Cancer Res. 2008 Aug 15;68(16):6831-9. doi: 10.1158/0008-5472.CAN-07-6195
Alteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats [PubMed]
Koyanagi T, Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H220-6. doi: 10.1152/ajpheart.00289.2008. Epub 2008 May 16
epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury [PubMed]
Bright R, Sun GH, Yenari MA, Steinberg GK, Mochly-Rosen D
Neurosci Lett. 2008 Aug 15;441(1):120-4. doi: 10.1016/j.neulet.2008.05.080. Epub 2008 May 27
Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure [PubMed]
Inagaki K, Koyanagi T, Berry NC, Sun L, Mochly-Rosen D
Hypertension. 2008 Jun;51(6):1565-9. doi: 10.1161/HYPERTENSIONAHA.107.109637. Epub 2008 Apr 14
Islet cell survival during isolation improved through protein kinase C epsilon activation [PubMed]
Kvezereli M, Vallentin A, Mochly-Rosen D, Busque S, Fontaine MJ
Transplant Proc. 2008 Mar;40(2):375-8. doi: 10.1016/j.transproceed.2008.01.014
Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways [PubMed]
Yao L, Fan P, Jiang Z, Gordon A, Mochly-Rosen D, Diamond I
Mol Pharmacol. 2008 Apr;73(4):1105-12. doi: 10.1124/mol.107.042580. Epub 2008 Jan 17
The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis [PubMed]
Qi X, Mochly-Rosen D
J Cell Sci. 2008 Mar 15;121(Pt 6):804-13. doi: 10.1242/jcs.024653. Epub 2008 Feb 19
Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction [PubMed]
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Circulation. 2008 Feb 19;117(7):886-96. doi: 10.1161/CIRCULATIONAHA.107.759167. Epub 2008 Feb 4
PKC isozymes in chronic cardiac disease: possible therapeutic targets? [PubMed]
Churchill E, Budas G, Vallentin A, Koyanagi T, Mochly-Rosen D
Annu Rev Pharmacol Toxicol. 2008;48:569-99
Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats [PubMed]
Qi X, Inagaki K, Sobel RA, Mochly-Rosen D
J Clin Invest. 2008 Jan;118(1):173-82
Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007) [PubMed]
Newton AC, Mochly-Rosen D
IUBMB Life. 2007 Dec;59(12):741-3
The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury [PubMed]
Churchill EN, Mochly-Rosen D
Biochem Soc Trans. 2007 Nov;35(Pt 5):1040-2
Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic [PubMed]
Budas GR, Koyanagi T, Churchill EN, Mochly-Rosen D
Biochem Soc Trans. 2007 Nov;35(Pt 5):1021-6
Mitochondrial protein kinase Cepsilon (PKCepsilon): emerging role in cardiac protection from ischaemic damage [PubMed]
Budas GR, Mochly-Rosen D
Biochem Soc Trans. 2007 Nov;35(Pt 5):1052-4
deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart [PubMed]
Qi X, Vallentin A, Churchill E, Mochly-Rosen D
J Mol Cell Cardiol. 2007 Oct;43(4):420-8. Epub 2007 Aug 8
Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model [PubMed]
Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D
J Mol Cell Cardiol. 2007 Oct;43(4):517-22. Epub 2007 Jun 21
Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia [PubMed]
Shimohata T, Zhao H, Sung JH, Sun G, Mochly-Rosen D, Steinberg GK
J Cereb Blood Flow Metab. 2007 Aug;27(8):1463-75. Epub 2007 Feb 7
Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function [PubMed]
Kheifets V, Mochly-Rosen D
Pharmacol Res. 2007 Jun;55(6):467-76. Epub 2007 May 3
Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury [PubMed]
Budas GR, Churchill EN, Mochly-Rosen D
Pharmacol Res. 2007 Jun;55(6):523-36. Epub 2007 Apr 29
Happy birthday protein kinase C: past, present and future of a superfamily [PubMed]
Battaini F, Mochly-Rosen D
Pharmacol Res. 2007 Jun;55(6):461-6. Epub 2007 May 18
Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase [PubMed]
Siwko S, Mochly-Rosen D
Int J Biochem Cell Biol. 2007;39(5):978-87. Epub 2007 Jan 24
Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide [PubMed]
Liron T, Chen LE, Khaner H, Vallentin A, Mochly-Rosen D
J Mol Cell Cardiol. 2007 Apr;42(4):835-41. Epub 2007 Jan 24
DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo [PubMed]
Bright R, Steinberg GK, Mochly-Rosen D
Brain Res. 2007 May 4;1144:146-55. Epub 2007 Feb 2
Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage [PubMed]
Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D
Cardiovasc Res. 2007 Mar 1;73(4):699-709. Epub 2006 Dec 13
Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces [PubMed]
Brandman R, Disatnik MH, Churchill E, Mochly-Rosen D
J Biol Chem. 2007 Feb 9;282(6):4113-23. Epub 2006 Dec 2
RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function [PubMed]
Vallentin A, Mochly-Rosen D
J Biol Chem. 2007 Jan 19;282(3):1650-7. Epub 2006 Nov 22
Peptide modulators of Src activity in G1 regulate entry into S phase and proliferation of NIH 3T3 cells [PubMed]
Mamidipudi V, Miller LD, Mochly-Rosen D, Cartwright CA
Biochem Biophys Res Commun. 2007 Jan 12;352(2):423-30. Epub 2006 Nov 15
Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function [PubMed]
Kheifets V, Bright R, Inagaki K, Schechtman D, Mochly-Rosen D
J Biol Chem. 2006 Aug 11;281(32):23218-26. Epub 2006 Jun 18
Epsilon protein kinase C as a potential therapeutic target for the ischemic heart [PubMed]
Inagaki K, Churchill E, Mochly-Rosen D
Cardiovasc Res. 2006 May 1;70(2):222-30. Epub 2006 Feb 23
The role of protein kinase C in cerebral ischemic and reperfusion injury [PubMed]
Bright R, Mochly-Rosen D
Stroke. 2005 Dec;36(12):2781-90. Epub 2005 Oct 27
RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death [PubMed]
Szabo G, Hoek JB, Darley-Usmar V, Hajnoczky G, Knudsen T, Mochly-Rosen D, Zakhari S
Alcohol Clin Exp Res. 2005 Sep;29(9):1749-52
PKC-{epsilon}-dependent survival signals in diabetic hearts [PubMed]
Malhotra A, Begley R, Kang BP, Rana I, Liu J, Yang G, Mochly-Rosen D, Meggs LG
Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1343-50. Epub 2005 May 13
Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes [PubMed]
Shumilla JA, Liron T, Mochly-Rosen D, Kendig JJ, Sweitzer SM
J Pain. 2005 Aug;6(8):535-49
DeltaPKC-mediated activation of epsilonPKC in ethanol-induced cardiac protection from ischemia [PubMed]
Inagaki K, Mochly-Rosen D
J Mol Cell Cardiol. 2005 Aug;39(2):203-11
Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation [PubMed]
Churchill EN, Murriel CL, Chen CH, Mochly-Rosen D, Szweda LI
Circ Res. 2005 Jul 8;97(1):78-85. Epub 2005 Jun 16
Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation [PubMed]
Raval AP, Dave KR, Prado R, Katz LM, Busto R, Sick TJ, Ginsberg MD, Mochly-Rosen D, Pérez-Pinzón MA
J Cereb Blood Flow Metab. 2005 Jun;25(6):730-41
Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators [PubMed]
Tanaka M, Gunawan F, Terry RD, Inagaki K, Caffarelli AD, Hoyt G, Tsao PS, Mochly-Rosen D, Robbins RC
J Thorac Cardiovasc Surg. 2005 May;129(5):1160-7
Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons [PubMed]
Li HF, Mochly-Rosen D, Kendig JJ
Br J Pharmacol. 2005 Feb;144(3):301-7
Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide [PubMed]
Inagaki K, Begley R, Ikeno F, Mochly-Rosen D
Circulation. 2005 Jan 4;111(1):44-50. Epub 2004 Dec 20
Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria [PubMed]
Murriel CL, Churchill E, Inagaki K, Szweda LI, Mochly-Rosen D
J Biol Chem. 2004 Nov 12;279(46):47985-91. Epub 2004 Aug 31
Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts [PubMed]
Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC
Circulation. 2004 Sep 14;110(11 Suppl 1):II194-9
Protein kinase C delta mediates cerebral reperfusion injury in vivo [PubMed]
Bright R, Raval AP, Dembner JM, Pérez-Pinzón MA, Steinberg GK, Yenari MA, Mochly-Rosen D
J Neurosci. 2004 Aug 4;24(31):6880-8
Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma [PubMed]
Sweitzer SM, Wong SM, Tjolsen A, Allen CP, Mochly-Rosen D, Kendig JJ
Pain. 2004 Jul;110(1-2):281-9
RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling [PubMed]
Miller LD, Lee KC, Mochly-Rosen D, Cartwright CA
Oncogene. 2004 Jul 22;23(33):5682-6
Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice [PubMed]
Lange-Asschenfeldt C, Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA
J Cereb Blood Flow Metab. 2004 Jun;24(6):636-45
Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury [PubMed]
Wang J, Bright R, Mochly-Rosen D, Giffard RG
Neuropharmacology. 2004 Jul;47(1):136-45
Biodistribution of intracellularly acting peptides conjugated reversibly to Tat [PubMed]
Begley R, Liron T, Baryza J, Mochly-Rosen D
Biochem Biophys Res Commun. 2004 Jun 11;318(4):949-54
Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats [PubMed]
Sweitzer SM, Wong SM, Peters MC, Mochly-Rosen D, Yeomans DC, Kendig JJ
J Pharmacol Exp Ther. 2004 May;309(2):616-25. Epub 2004 Feb 4
State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation [PubMed]
Souroujon MC, Yao L, Chen H, Endemann G, Khaner H, Geeraert V, Schechtman D, Gordon AS, Diamond I, Mochly-Rosen D
J Biol Chem. 2004 Apr 23;279(17):17617-24. Epub 2004 Feb 3
A critical intramolecular interaction for protein kinase Cepsilon translocation [PubMed]
Schechtman D, Craske ML, Kheifets V, Meyer T, Schechtman J, Mochly-Rosen D
J Biol Chem. 2004 Apr 16;279(16):15831-40. Epub 2004 Jan 22
Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon [PubMed]
Gray MO, Zhou HZ, Schafhalter-Zoppoth I, Zhu P, Mochly-Rosen D, Messing RO
J Biol Chem. 2004 Jan 30;279(5):3596-604. Epub 2003 Nov 4
Opposing roles of delta and epsilonPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery [PubMed]
Murriel CL, Mochly-Rosen D
Arch Biochem Biophys. 2003 Dec 15;420(2):246-54
Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo [PubMed]
Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D
Circulation. 2003 Nov 11;108(19):2304-7. Epub 2003 Nov 3
Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator [PubMed]
Inagaki K, Hahn HS, Dorn GW 2nd, Mochly-Rosen D
Circulation. 2003 Aug 19;108(7):869-75. Epub 2003 Jul 14
Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors [PubMed]
Braun MU, Mochly-Rosen D
J Mol Cell Cardiol. 2003 Aug;35(8):895-903
Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta [PubMed]
Koponen S, Kurkinen K, Akerman KE, Mochly-Rosen D, Chan PH, Koistinaho J
J Neurochem. 2003 Jul;86(2):442-50
Glutathione S-transferase pull-down assay [PubMed]
Schechtman D, Mochly-Rosen D, Ron D
Methods Mol Biol. 2003;233:345-50
Methods for detecting binding proteins: an introduction [PubMed]
Endemann G, Mochly-Rosen D
Methods Mol Biol. 2003;233:307-25
Overlay method for detecting protein-protein interactions [PubMed]
Schechtman D, Murriel C, Bright R, Mochly-Rosen D
Methods Mol Biol. 2003;233:351-7
PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current [PubMed]
Xiao GQ, Mochly-Rosen D, Boutjdir M
Biochem Biophys Res Commun. 2003 Jul 11;306(4):1019-25
Cytotoxicity of pEGFP vector is due to residues encoded by multiple cloning site [PubMed]
Endemann G, Schechtman D, Mochly-Rosen D
Anal Biochem. 2003 Feb 15;313(2):345-7
Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice [PubMed]
Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA
J Neurosci. 2003 Jan 15;23(2):384-91
The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins [PubMed]
Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Mochly-Rosen D, Hamm HE
J Biol Chem. 2002 Dec 20;277(51):49888-95. Epub 2002 Sep 30
Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta [PubMed]
Inagaki K, Iwanaga Y, Sarai N, Onozawa Y, Takenaka H, Mochly-Rosen D, Kihara Y
J Mol Cell Cardiol. 2002 Oct;34(10):1377-85
Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts [PubMed]
Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO
Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H1970-7
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon [PubMed]
Knauf JA, Ward LS, Nikiforov YE, Nikiforova M, Puxeddu E, Medvedovic M, Liron T, Mochly-Rosen D, Fagin JA
J Clin Endocrinol Metab. 2002 May;87(5):2150-9
Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway [PubMed]
Disatnik MH, Boutet SC, Lee CH, Mochly-Rosen D, Rando TA
J Cell Sci. 2002 May 15;115(Pt 10):2151-63
Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta [PubMed]
Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI
Mol Biol Cell. 2002 Apr;13(4):1381-9
Molecular dynamics characterization of the C2 domain of protein kinase Cbeta [PubMed]
Banci L, Cavallaro G, Kheifets V, Mochly-Rosen D
J Biol Chem. 2002 Apr 12;277(15):12988-97. Epub 2002 Jan 8
Intracellular transport mechanisms of signal transducers [PubMed]
Dorn GW 2nd, Mochly-Rosen D
Annu Rev Physiol. 2002;64:407-29
Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7) [PubMed]
Chen L, Wright LR, Chen CH, Oliver SF, Wender PA, Mochly-Rosen D
Chem Biol. 2001 Dec;8(12):1123-9
Isozyme-specific inhibitors and activators of protein kinase C [PubMed]
Schechtman D, Mochly-Rosen D
Methods Enzymol. 2002;345:470-89
Adaptor proteins in protein kinase C-mediated signal transduction [PubMed]
Schechtman D, Mochly-Rosen D
Oncogene. 2001 Oct 1;20(44):6339-47
Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Na(+) channels [PubMed]
Xiao GQ, Qu Y, Sun ZQ, Mochly-Rosen D, Boutjdir M
Am J Physiol Cell Physiol. 2001 Nov;281(5):C1477-86
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC [PubMed]
Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavallaro G, Banci L, Guo Y, Bolli R, Dorn GW 2nd, Mochly-Rosen D
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11114-9. Epub 2001 Sep 11
Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C [PubMed]
Stebbins EG, Mochly-Rosen D
J Biol Chem. 2001 Aug 10;276(32):29644-50. Epub 2001 May 31
Localization, anchoring, and functions of protein kinase C isozymes in the heart [PubMed]
Mackay K, Mochly-Rosen D
J Mol Cell Cardiol. 2001 Jul;33(7):1301-7
Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis [PubMed]
Mochly-Rosen D, Fagin JA, Knauf JA, Nikiforov Y, Liron T, Schechtman D
Adv Enzyme Regul. 2001;41:87-97
Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C [PubMed]
Mackay K, Mochly-Rosen D
Cardiovasc Res. 2001 Apr;50(1):65-74
Opposing effects of delta and xi PKC in ethanol-induced cardioprotection [PubMed]
Chen C, Mochly-Rosen D
J Mol Cell Cardiol. 2001 Mar;33(3):581-5
Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Ca(2+) channels [PubMed]
Hu K, Mochly-Rosen D, Boutjdir M
Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H2658-64
Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia [PubMed]
Mackay K, Mochly-Rosen D
J Mol Cell Cardiol. 2000 Aug;32(8):1585-8
Protein kinase C isozymes and the regulation of diverse cell responses [PubMed]
Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO
Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L429-38
Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation [PubMed]
Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, Dorn GW 2nd
Circ Res. 2000 Jun 9;86(11):1173-9
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C [PubMed]
Aley KO, Messing RO, Mochly-Rosen D, Levine JD
J Neurosci. 2000 Jun 15;20(12):4680-5
Pharmacological regulation of network kinetics by protein kinase C localization [PubMed]
Mochly-Rosen D, Kauvar LM
Semin Immunol. 2000 Feb;12(1):55-61
Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation [PubMed]
Dorn GW 2nd, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN, Mochly-Rosen D
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12798-803
Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C [PubMed]
Chen CH, Gray MO, Mochly-Rosen D
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12784-9
RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro [PubMed]
Rodriguez MM, Ron D, Touhara K, Chen CH, Mochly-Rosen D
Biochemistry. 1999 Oct 19;38(42):13787-94
Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes [PubMed]
Liu GS, Cohen MV, Mochly-Rosen D, Downey JM
J Mol Cell Cardiol. 1999 Oct;31(10):1937-48
Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis [PubMed]
Knauf JA, Elisei R, Mochly-Rosen D, Liron T, Chen XN, Gonsky R, Korenberg JR, Fagin JA
J Biol Chem. 1999 Aug 13;274(33):23414-25
Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C [PubMed]
Rodriguez MM, Chen CH, Smith BL, Mochly-Rosen D
FEBS Lett. 1999 Jul 9;454(3):240-6
Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation [PubMed]
Csukai M, Mochly-Rosen D
Pharmacol Res. 1999 Apr;39(4):253-9
An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia [PubMed]
Mackay K, Mochly-Rosen D
J Biol Chem. 1999 Mar 5;274(10):6272-9
Peptide modulators of protein-protein interactions in intracellular signaling [PubMed]
Souroujon MC, Mochly-Rosen D
Nat Biotechnol. 1998 Oct;16(10):919-24
Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis [PubMed]
Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC
J Biol Chem. 1998 Nov 13;273(46):30306-15
Molecular genetic approaches. II. Expression-interaction cloning [PubMed]
Csukai M, Mochly-Rosen D
Methods Mol Biol. 1998;88:133-9
Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption [PubMed]
Miyamae M, Rodriguez MM, Camacho SA, Diamond I, Mochly-Rosen D, Figueredo VM
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8262-7
Modulating protein kinase C signal transduction [PubMed]
Mochly-Rosen D, Kauvar LM
Adv Pharmacol. 1998;44:91-145
Anchoring proteins for protein kinase C: a means for isozyme selectivity [PubMed]
Mochly-Rosen D, Gordon AS
FASEB J. 1998 Jan;12(1):35-42
A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death [PubMed]
Gray MO, Karliner JS, Mochly-Rosen D
J Biol Chem. 1997 Dec 5;272(49):30945-51
The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon [PubMed]
Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D
J Biol Chem. 1997 Nov 14;272(46):29200-6
An inhibitory fragment derived from protein kinase Cepsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters [PubMed]
Hundle B, McMahon T, Dadgar J, Chen CH, Mochly-Rosen D, Messing RO
J Biol Chem. 1997 Jun 6;272(23):15028-35
C2 region-derived peptides of beta-protein kinase C regulate cardiac Ca2+ channels [PubMed]
Zhang ZH, Johnson JA, Chen L, El-Sherif N, Mochly-Rosen D, Boutjdir M
Circ Res. 1997 May;80(5):720-9
Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells [PubMed]
Yedovitzky M, Mochly-Rosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E, Nesher R
J Biol Chem. 1997 Jan 17;272(3):1417-20
An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research [PubMed]
Johnson JA, Gray MO, Karliner JS, Chen CH, Mochly-Rosen D
Circ Res. 1996 Dec;79(6):1086-99
Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells [PubMed]
Zhou LY, Disatnik M, Herron GS, Mochly-Rosen D, Karasek MA
J Invest Dermatol. 1996 Aug;107(2):248-52
A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function [PubMed]
Johnson JA, Gray MO, Chen CH, Mochly-Rosen D
J Biol Chem. 1996 Oct 4;271(40):24962-6
The HIV nef protein associates with protein kinase C theta [PubMed]
Smith BL, Krushelnycky BW, Mochly-Rosen D, Berg P
J Biol Chem. 1996 Jul 12;271(28):16753-7
Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis [PubMed]
Cardone MH, Smith BL, Mennitt PA, Mochly-Rosen D, Silver RB, Mostov KE
J Cell Biol. 1996 Jun;133(5):997-1005
Stimulus-dependent subcellular localization of activated protein kinase C; a study with acidic fibroblast growth factor and transforming growth factor-beta 1 in cardiac myocytes [PubMed]
Disatnik MH, Jones SN, Mochly-Rosen D
J Mol Cell Cardiol. 1995 Nov;27(11):2473-81
Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: a role in beta protein kinase C mediated signal transduction [PubMed]
Mochly-Rosen D, Smith BL, Chen CH, Disatnik MH, Ron D
Biochem Soc Trans. 1995 Aug;23(3):596-600
C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo [PubMed]
Ron D, Luo J, Mochly-Rosen D
J Biol Chem. 1995 Oct 13;270(41):24180-7
Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes [PubMed]
Johnson JA, Adak S, Mochly-Rosen D
Life Sci. 1995;57(11):1027-38
The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor [PubMed]
Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF
Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7824-8
Localization of protein kinases by anchoring proteins: a theme in signal transduction [PubMed]
Mochly-Rosen D
Science. 1995 Apr 14;268(5208):247-51
Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme [PubMed]
Johnson JA, Mochly-Rosen D
Circ Res. 1995 Apr;76(4):654-63
An autoregulatory region in protein kinase C: the pseudoanchoring site [PubMed]
Ron D, Mochly-Rosen D
Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):492-6
Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells [PubMed]
Disatnik MH, Winnier AR, Mochly-Rosen D, Arteaga CL
Cell Growth Differ. 1994 Aug;5(8):873-80
Developmental expression of protein kinase C subspecies in rat brain-pituitary axis [PubMed]
Garcia-Navarro S, Marantz Y, Eyal R, Kalina M, Disatnik MH, Mochly-Rosen D, Ben-Menahem D, Reiss N, Naor Z
Mol Cell Endocrinol. 1994 Jul;103(1-2):133-8
Agonists and antagonists of protein kinase C function, derived from its binding proteins [PubMed]
Ron D, Mochly-Rosen D
J Biol Chem. 1994 Aug 26;269(34):21395-8
Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells [PubMed]
Cardone MH, Smith BL, Song W, Mochly-Rosen D, Mostov KE
J Cell Biol. 1994 Mar;124(5):717-27
Localization of protein kinase C isozymes in cardiac myocytes [PubMed]
Disatnik MH, Buraggi G, Mochly-Rosen D
Exp Cell Res. 1994 Feb;210(2):287-97
Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins [PubMed]
Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):839-43
Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C [PubMed]
Disatnik MH, Hernandez-Sotomayor SM, Jones G, Carpenter G, Mochly-Rosen D
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):559-63
Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme [PubMed]
Smith BL, Mochly-Rosen D
Biochem Biophys Res Commun. 1992 Nov 16;188(3):1235-40
Nicotinic acetylcholine receptor desensitization is regulated by activation-induced extracellular adenosine accumulation [PubMed]
Pitchford S, Day JW, Gordon A, Mochly-Rosen D
J Neurosci. 1992 Nov;12(11):4540-4
p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C [PubMed]
Mochly-Rosen D, Miller KG, Scheller RH, Khaner H, Lopez J, Smith BL
Biochemistry. 1992 Sep 8;31(35):8120-4
Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme [PubMed]
Mochly-Rosen D, Khaner H, Lopez J, Smith BL
J Biol Chem. 1991 Aug 15;266(23):14866-8
The identification and purification of a mammalian-like protein kinase C in the yeast Saccharomyces cerevisiae [PubMed]
Simon AJ, Milner Y, Saville SP, Dvir A, Mochly-Rosen D, Orr E
Proc Biol Sci. 1991 Feb 22;243(1307):165-71
The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism [PubMed]
Diamond I, Nagy L, Mochly-Rosen D, Gordon A
Ann N Y Acad Sci. 1991;625:473-87
Identification of intracellular receptor proteins for activated protein kinase C [PubMed]
Mochly-Rosen D, Khaner H, Lopez J
Proc Natl Acad Sci U S A. 1991 May 1;88(9):3997-4000
A protein kinase C isozyme is translocated to cytoskeletal elements on activation [PubMed]
Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC
Cell Regul. 1990 Aug;1(9):693-706
GTP-binding proteins are restricted to signal transduction sites [PubMed]
Mochly-Rosen D, Gordon AS
Biochem Biophys Res Commun. 1990 Nov 30;173(1):388-95
Chronic ethanol-induced heterologous desensitization is mediated by changes in adenosine transport [PubMed]
Gordon AS, Nagy L, Mochly-Rosen D, Diamond I
Biochem Soc Symp. 1990;56:117-36
A general procedure for screening inhibitory antibodies: application for identifying anti-protein kinase C antibodies [PubMed]
Mochly-Rosen D, Koshland DE Jr
Anal Biochem. 1988 Apr;170(1):31-7
Chronic ethanol causes heterologous desensitization of receptors by reducing alpha s messenger RNA [PubMed]
Mochly-Rosen D, Chang FH, Cheever L, Kim M, Diamond I, Gordon AS
Nature. 1988 Jun 30;333(6176):848-50
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C [PubMed]
Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE Jr, Cole RD
Biochemistry. 1987 May 19;26(10):2886-93
Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain [PubMed]
Mochly-Rosen D, Basbaum AI, Koshland DE Jr
Proc Natl Acad Sci U S A. 1987 Jul;84(13):4660-4
Exposure of HeLa DNA polymerase alpha to protein kinase C affects its catalytic properties [PubMed]
Krauss SW, Mochly-Rosen D, Koshland DE Jr, Linn S
J Biol Chem. 1987 Mar 15;262(8):3432-5
Domain structure and phosphorylation of protein kinase C [PubMed]
Mochly-Rosen D, Koshland DE Jr
J Biol Chem. 1987 Feb 15;262(5):2291-7
Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity [PubMed]
Bollag GE, Roth RA, Beaudoin J, Mochly-Rosen D, Koshland DE Jr
Proc Natl Acad Sci U S A. 1986 Aug;83(16):5822-4
Antigenic specificity of acetylcholine receptor in developing muscle. Studies with monoclonal antibodies [PubMed]
Souroujon MC, Pizzighella S, Mochly-Rosen D, Fuchs S
J Neuroimmunol. 1985 May;8(2-3):159-66
Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs [PubMed]
Goldberg G, Mochly-Rosen D, Fuchs S, Lass Y
J Membr Biol. 1983;76(2):123-8
An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin [PubMed]
Pizzighella S, Gordon AS, Souroujon MC, Mochly-Rosen D, Sharp A, Fuchs S
FEBS Lett. 1983 Aug 8;159(1-2):246-50
Interaction of monoclonal antibodies to Torpedo acetylcholine receptor with the receptor of skeletal muscle [PubMed]
Souroujon MC, Mochly-Rosen D, Gordon AS, Fuchs S
Muscle Nerve. 1983 May;6(4):303-11
Acetylcholine receptor: molecular dissection and monoclonal antibodies in the study of experimental myasthenia [PubMed]
Fuchs S, Bartfeld D, Mochly-Rosen D, Souroujon M, Feingold C
Ann N Y Acad Sci. 1981;377:110-24
Molecular aspects of experimental autoimmune myasthenia gravis [PubMed]
Fuchs S, Bartfeld D, Mochly-Rosen D, Schmidt-Hopfeld I, Tarrab-Hazdai R
Prog Clin Biol Res. 1981;63:405-17
Monoclonal anti-acetylcholine-receptor antibodies directed against the cholinergic binding site [PubMed]
Mochly-Rosen D, Fuchs S
Biochemistry. 1981 Sep 29;20(20):5920-4
Modification of acetylcholine receptor: chemical and immunological characterization of polyalanyl acetylcholine receptor [PubMed]
Tarrab-Hazdai R, Schmidt-Sole Y, Mochly-Rosen D, Fuchs S
FEBS Lett. 1980 Aug 25;118(1):35-8
Immune regulation of experimental myasthenia [PubMed]
Fuchs S, Bartfeld D, Eshhar Z, Feingold C, Mochly-Rosen D, Novick D, Schwartz M, Tarrab-Hazdai R
J Neurol Neurosurg Psychiatry. 1980 Jul;43(7):634-43
PKCε activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting [PubMed]
Monti M, Donnini S, Morbidelli L, Giachetti A, Mochly-Rosen D, Mignatti P, Ziche M
J Mol Cell Cardiol. 2013 Oct;63:107-17. doi: 10.1016/j.yjmcc.2013.07.006. Epub 2013 Jul 20