Welcome to the Computational Arrhythmia Research Laboratory at Stanford University.

Our mission is to improve the therapy of patients with complex heart rhythm disorders (arrhythmias), particularly atrial fibrillation (AF) and ventricular fibrillation (AF), by developing bioengineering solutions to improve mechanistic understanding and improve clinical practice.  Our laboratory mantra is: “bedside-to-bench-to-bedside” research, that we achieve by an iterative process combining rigorous numerical methods, signal processing and computational models with detailed physiological studies in patients. A key development from our laboratory since 2001 has been to develop clinical tools to map cardiac fibrillation that computationally approximate optical mapping – a gold standard that is currently unavailable in patients – to clarify mechanistic confusion caused by limitations of classical electrogram analysis.  Our laboratory pioneered Focal Impulse and Rotor Mapping (FIRM) of fibrillation, leading to the discovery presented in 2011 in the CONFIRM trial that human AF is maintained by localized circuits (rotors).  These results are now validated by many groups using FIRM, by others using different methods and are similar to recent mapping of AF in human hearts by optical mapping.

Contact us here.

Pictured (from left):
Mahmood Al-Husseini, AJ Rogers, Christopher Kowalewski, Kathleen Mills, Fatemah Shenasa, Dr. Sanjiv Narayan (Director), Junaid Zaman

Lab News:

November 2015

Junaid Zaman, postdoctoral fellow was a finalist for the Samuel A. Levine Young Clinical Investigator finals at the American Heart Association in Orlando, FL, November 2015. The abstract entitled Phase Analysis Detects Human Atrial Fibrillation Sources While Classical Activation Mapping May Not: Reconciling Classical and Computational Mapping demonstrates that the mapping techniques used to study AF themselves explain a century old debate in underlying mechanisms of the condition and offers insight into how mapping can improve patient outcome.

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Dr. Zaman’s interview at AHA can be viewed at: https://vimeo.com/145348944

May 2015

Tina Baykaner was awarded the HRS Research Fellowship Scholarship in Honor of Mark Josephson and Hein Wellens for her project entitled Treating Atrial Fibrillation by Decoupling Disorganized Activity from Sources.

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Dr. Tina Baykaner presenting her poster ‘Does Atrial Fibrillation Organize Spatially or Temporally Before Termination?  Continuous Tracking of Spatio-Temporal Periodicity During Ablation’ at HRS 2015

 

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Dr. Baykaner with co-authors David Krummen, Sanjiv Narayan, Junaid Zaman and Paul Wang at HRS 2015.

March 2015

Junaid Zaman was awarded the inaugural Fulbright British Heart Foundation Award for his project entitled ‘Identifying and Treating Novel Substrates For Life-Threatening Clinical Ventricular Fibrillation’.  This is a multi-center study testing a completely new method of preventing sudden cardiac death in high risk patients.

Learn more here and here.

December 2014

The FIRM mapping software and RhythmView® earned the Most Innovative Product award at the UCSD Connect Showcase.

Learn more here.

August 2014

Junaid Zaman was awarded a British Heart Foundation Travel Grant to work at Stanford in 2014 for a postdoctoral project entitled ‘Defining the Electrogram Fingerprint of Substrates that Sustain Persistent Atrial Fibrillation’. This study addresses whether characteristic signatures of AF sources exist and how they may help improve treatment strategies. The study is in collaboration with Professor Nicholas Peters at Imperial College London, Dr Zaman’s PhD supervisor.

May 2013

Amir Schricker won first place at the Young Investigator Awards Competition of the Heart Rhythm Society for his project entitled ‘Human Atrial Fibrillation Is Initiated By Spiral Waves That Form at Sites Predicted by Dynamic Conduction Slowing’

January 2013

Amir Schricker won American College of Cardiology/Merck Foundation Grant for his project entitled ‘Transducing Mechanisms that Enable Ectopic Beats to Initiate Human Atrial Fibrillation’