Welcome to the Computational Arrhythmia Research Laboratory at Stanford University.

Our mission is to improve the therapy of patients with complex heart rhythm disorders (arrhythmias) by developing bioengineering solutions to clarify mechanisms and improve therapy.  Our focus is atrial fibrillation (AF) and ventricular fibrillation (VF).  Our guiding principle is to perform: “bedside-to-bench-to-bedside” research, by iteratively combining rigorous signal processing methods with computational methods including machine learning and logging response to physiologically-tailored therapy.  Since 2001, we have had several key achievements.  First, development of physiologically-guided methods to understand electrical signals (electrograms) during AF and VF by using monophasic action potential recordings, contact basket recordings and ablation in patients at clinically indicated electrophysiology study and ablation.  Second, to use these tools to clarify mechanisms, by demonstrating rotational and focal sources during clinical AF and VF that have now been validated by independent clinical groups and by optical mapping in human hearts.  Third, to demonstrate proof-of-concept that ablating these sites (Focal Impulse and Rotor Modulation, FIRM) can effectively treat these conditions in initial trials. Finally, making mapping more accessible to others by placing AF mapping software, visualization tools and de-identified contact basket recordings available as downloadable executables and Smartphone apps.

 

Contact us here.

Pictured (from left):
Mahmood Al-Husseini, AJ Rogers, Christopher Kowalewski, Kathleen Mills, Fatemah Shenasa, Dr. Sanjiv Narayan (Director), Junaid Zaman

Lab News:

May 2018

AJ Rogers, MD MBA, postdoctoral fellow was awarded the 2018 Clinical Research Fellowship of the Heart Rhythm Society in Honor of Mark Josephson and Hein Wellens.  His project is entitled Novel Atrial Fibrillation Phenotypes Defined by Functional-Anatomical, Machine-Learned Classifications.

August 2017

Junaid Zaman, postdoctoral fellow was awarded best poster at the 2017 Scientific Sessions of the European Society of Cardiology.  His abstract was entitled Electrogram Mapping of Human Atria At Sites Where Localized Ablation terminates Persistent Atrial Fibrillation.

January 2017

Rachita Navara, MD, postdoctoral fellow was awarded 1st place in the Research Poster Category at the 2017 Scientific Sessions of the Society for General Internal Medicine in Los Angeles, CA.  Her abstract was entitled Termination of Atrial Fibrillation During Pulmonary Vein Ablation Before Isolation: Evidence for Localized Sources.

Navara

November 2015

Junaid Zaman, postdoctoral fellow was a finalist for the Samuel A. Levine Young Clinical Investigator finals at the American Heart Association in Orlando, FL, November 2015. The abstract entitled Phase Analysis Detects Human Atrial Fibrillation Sources While Classical Activation Mapping May Not: Reconciling Classical and Computational Mapping demonstrates that the mapping techniques used to study AF themselves explain a century old debate in underlying mechanisms of the condition and offers insight into how mapping can improve patient outcome.

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Dr. Zaman’s interview at AHA can be viewed at: https://vimeo.com/145348944

May 2015

Tina Baykaner was awarded the HRS Research Fellowship Scholarship in Honor of Mark Josephson and Hein Wellens for her project entitled Treating Atrial Fibrillation by Decoupling Disorganized Activity from Sources.

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Dr. Tina Baykaner presenting her poster ‘Does Atrial Fibrillation Organize Spatially or Temporally Before Termination?  Continuous Tracking of Spatio-Temporal Periodicity During Ablation’ at HRS 2015

 

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Dr. Baykaner with co-authors David Krummen, Sanjiv Narayan, Junaid Zaman and Paul Wang at HRS 2015.

March 2015

Junaid Zaman was awarded the inaugural Fulbright British Heart Foundation Award for his project entitled ‘Identifying and Treating Novel Substrates For Life-Threatening Clinical Ventricular Fibrillation’.  This is a multi-center study testing a completely new method of preventing sudden cardiac death in high risk patients.

Learn more here and here.

December 2014

The FIRM mapping software and RhythmView® earned the Most Innovative Product award at the UCSD Connect Showcase.

Learn more here.

August 2014

Junaid Zaman was awarded a British Heart Foundation Travel Grant to work at Stanford in 2014 for a postdoctoral project entitled ‘Defining the Electrogram Fingerprint of Substrates that Sustain Persistent Atrial Fibrillation’. This study addresses whether characteristic signatures of AF sources exist and how they may help improve treatment strategies. The study is in collaboration with Professor Nicholas Peters at Imperial College London, Dr Zaman’s PhD supervisor.

May 2013

Amir Schricker won first place at the Young Investigator Awards Competition of the Heart Rhythm Society for his project entitled ‘Human Atrial Fibrillation Is Initiated By Spiral Waves That Form at Sites Predicted by Dynamic Conduction Slowing’

January 2013

Amir Schricker won American College of Cardiology/Merck Foundation Grant for his project entitled ‘Transducing Mechanisms that Enable Ectopic Beats to Initiate Human Atrial Fibrillation’