Beta-catenin: a key mediator of Wnt signaling.

TitleBeta-catenin: a key mediator of Wnt signaling.
Publication TypeJournal Article
Year of Publication1998
AuthorsWillert K, Nusse R
JournalCurr Opin Genet Dev
Date PublishedFeb
ISSN0959-437X (Print); 0959-437X (Linking)
AbstractBeta-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. beta-catenin activity is controlled by a large number of binding partners that affect the stability and the localization of beta-catenin and is thereby able to participate in such varying processes as gene expression and cell adhesion. Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors.