dishevelled and armadillo act in the wingless signalling pathway in Drosophila.

Titledishevelled and armadillo act in the wingless signalling pathway in Drosophila.
Publication TypeJournal Article
Year of Publication1994
AuthorsNoordermeer J, Klingensmith J, Perrimon N, Nusse R
JournalNature
Volume367
Pagination80–83
Date PublishedJan
ISSN0028-0836 (Print); 0028-0836 (Linking)
AbstractThe Wnt genes encode conserved secreted proteins that play a role in normal development and tumorigenesis. Little is known about the signal transduction pathways of Wnt gene products. One of the best characterized Wnt family members is the Drosophila segment polarity gene wingless. We have investigated whether segment polarity genes with a wingless-like phenotype mediate the wingless signal. We used a wingless transgene controlled by a heat-shock promoter for genetic epistasis experiments. We show that wingless acts through dishevelled and armadillo to affect the expression of the homeobox gene engrailed and cuticle differentiation.
DOI10.1038/367080a0