Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.
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| Title | Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells. |
| Publication Type | Journal Article |
| Year of Publication | 1989 |
| Authors | Schuuring E, van Deemter L, Roelink H, Nusse R |
| Journal | Mol Cell Biol |
| Volume | 9 |
| Pagination | 1357–1361 |
| Date Published | Mar |
| ISSN | 0270-7306 (Print); 0270-7306 (Linking) |
| Abstract | In mouse embryos, the int-1 proto-oncogene is transiently expressed in areas of the developing neural system. Retinoic acid-treated P19 embryonal carcinoma cells have often been used as an in vitro model for the molecular basis of neural development. We shown here that int-1 is transiently expressed in differentiated P19 cells. The time course and retinoic acid dose dependence of int-1 expression suggest that the gene is specifically expressed during early neural differentiation. P19 cells may be a useful model to assist in the study, at the cellular level, of the role of int-1 in neural development. |
