Molecular cloning and chromosomal assignment of the human homolog of int-1, a mouse gene implicated in mammary tumorigenesis.

TitleMolecular cloning and chromosomal assignment of the human homolog of int-1, a mouse gene implicated in mammary tumorigenesis.
Publication TypeJournal Article
Year of Publication1984
Authorsvan 't Veer LJ, van Kessel AG, van Heerikhuizen H, van Ooyen A, Nusse R
JournalMol Cell Biol
Volume4
Pagination2532–2534
Date PublishedNov
ISSN0270-7306 (Print); 0270-7306 (Linking)
AbstractViral mammary tumorigenesis in mice is frequently initiated by proviral activation of a highly conserved cellular gene called int-1. We have cloned the human homolog of this putative mammary oncogene and compared its structure to that of the mouse gene by heteroduplex analysis. The human int-1 gene was localized on chromosome 12 by use of somatic cell hybrids.