Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis.
Submitted by Anonymous on Sun, 02/19/2012 - 03:35
Title | Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Bowman A, Nusse R |
Journal | Cancer cell |
Volume | 20 |
Issue | 4 |
Pagination | 415-6 |
Date Published | 2011 Oct 18 |
ISSN | 1535-6108 |
Abstract | Genetic alterations in the Wnt/β-catenin/TCF-signaling pathway are commonly found in human tumors, but not in glioblastomas. In this issue of Cancer Cell, Zhang et al. report that FoxM1 mediates β-catenin nuclear translocation in glioblastoma, suggesting a novel mechanism for glioblastoma progression in the absence of conventional Wnt/β-catenin pathway activation. |
URL | http://linkinghub.elsevier.com/retrieve/pii/S1535-6108(11)00362-X |
DOI | 10.1016/j.ccr.2011.10.003 |
Short Title | Cancer Cell |