Wnt/β-catenin signaling and disease.
|Title||Wnt/β-catenin signaling and disease. |
|Publication Type||Journal Article |
|Year of Publication||2012 |
|Authors||Clevers H, Nusse R |
|Date Published||2012 Jun 8 |
|Abstract||The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future. |
|Short Title||Cell |