Wnt/β-catenin signaling and disease.
Submitted by Anonymous on Wed, 10/10/2012 - 11:40
Title | Wnt/β-catenin signaling and disease. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Clevers H, Nusse R |
Journal | Cell |
Volume | 149 |
Issue | 6 |
Pagination | 1192-205 |
Date Published | 2012 Jun 8 |
ISSN | 0092-8674 |
Abstract | The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future. |
URL | http://linkinghub.elsevier.com/retrieve/pii/S0092-8674(12)00586-7 |
DOI | 10.1016/j.cell.2012.05.012 |
Short Title | Cell |