Fibrosis of the Neonatal Mouse Heart After Cryoinjury Is Accompanied by Wnt Signaling Activation and Epicardial-to-Mesenchymal Transition.

TitleFibrosis of the Neonatal Mouse Heart After Cryoinjury Is Accompanied by Wnt Signaling Activation and Epicardial-to-Mesenchymal Transition.
Publication TypeJournal Article
Year of Publication2016
AuthorsMizutani M, Wu JC, Nusse R
JournalJournal of the American Heart Association
Volume5
Issue3
Paginatione002457
Date Published2016 Mar 15
AbstractThe adult mammalian heart responds to cardiac injury by formation of persistent fibrotic scar that eventually leads to heart failure. In contrast, the neonatal mammalian heart reacts to injury by the development of transient fibrotic tissue that is eventually replaced by regenerated cardiomyocytes. How fibrosis occurs in the neonatal mammalian heart remains unknown. To start elucidating the molecular underpinnings of neonatal cardiac fibrosis, we investigated Wnt signaling in the neonatal heart after cryoinjury.
URLhttp://jaha.ahajournals.org/cgi/pmidlookup?view=long&pmid=27068625
DOI10.1161/JAHA.115.002457
Short TitleJ Am Heart Assoc