@article {cite-key,
	title = {Alternative wnt signaling is initiated by distinct receptors.},
	journal = {Sci Signal},
	volume = {1},
	number = {35},
	year = {2008},
	pages = {re9},
	address = {Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.},
	abstract = {An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example.},
	issn = {1937-9145 (Electronic)},
	doi = {10.1126/scisignal.135re9},
	author = {van Amerongen, Renee and Mikels, Amanda and Nusse, Roel}
}
