@article {cite-key,
	title = {A dermal HOX transcriptional program regulates site-specific epidermal fate.},
	journal = {Genes Dev},
	volume = {22},
	number = {3},
	year = {2008},
	month = {Feb},
	pages = {303{\textendash}307},
	address = {Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA.},
	abstract = {Reciprocal epithelial-mesenchymal interactions shape site-specific development of skin. Here we show that site-specific HOX expression in fibroblasts is cell-autonomous and epigenetically maintained. The distal-specific gene HOXA13 is continually required to maintain the distal-specific transcriptional program in adult fibroblasts, including expression of WNT5A, a morphogen required for distal development. The ability of distal fibroblasts to induce epidermal keratin 9, a distal-specific gene, is abrogated by depletion of HOXA13, but rescued by addition of WNT5A. Thus, maintenance of appropriate HOX transcriptional program in adult fibroblasts may serve as a source of positional memory to differentially pattern the epithelia during homeostasis and regeneration.},
	issn = {0890-9369 (Print); 0890-9369 (Linking)},
	doi = {10.1101/gad.1610508},
	author = {Rinn, John L and Wang, Jordon K and Allen, Nancy and Brugmann, Samantha A and Mikels, Amanda J and Liu, Helen and Ridky, Todd W and Stadler, H Scott and Nusse, Roel and Helms, Jill A and Chang, Howard Y}
}
