%0 Journal Article %J Gynecologic oncology %D 2018 %T Gene expression profiling of low-grade endometrial stromal sarcoma indicates fusion protein-mediated activation of the Wnt signaling pathway. %A Przybyl, J %A Kidzinski, L %A Hastie, T %A Debiec-Rychter, M %A Nusse, R %A van de Rijn, M %N 2 %P 388-393 %R 10.1016/j.ygyno.2018.03.007 %U https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(18)30177-X %V 149 %X Low-grade endometrial stromal sarcomas (LGESS) harbor chromosomal translocations that affect proteins associated with chromatin remodeling Polycomb Repressive Complex 2 (PRC2), including SUZ12, PHF1 and EPC1. Roughly half of LGESS also demonstrate nuclear accumulation of β-catenin, which is a hallmark of Wnt signaling activation. However, the targets affected by the fusion proteins and the role of Wnt signaling in the pathogenesis of these tumors remain largely unknown. %8 2018 May