Drosophila Wnt genes

Drosophila

There are 7 Wnt genes in Drosophila, and loss of function mutants have been described for 5 of them. See table of syntenic mouse/human/Drosophila genes for more genomics

See Drosophila Frizzleds for binding of Wnt proteins to Frizzleds


 gene (flybase)

 location

 phenotype

related to (vertebrate ortholog)

27F segment polarity, many others Wnt1
45E
Pigment cells gonads; Kozopas 1998
adult muscle Kozopas 2002
Trachea (with wg) Llimargas 2001
Wnt7
17B
Axon Guidance (through Derailed)
Yoshikawa 2003
Wnt5
27F
Cell Movement in ovary Cohen 2002
Dorsoventral specificity of retinal projections (Sato 2006)
synaptic target specificity (Inaki 2007)
Wnt9
 27F    Wnt6
 87E  Antagonist Dorsal , immunity phenotype (Gordon et al, 2005; Ganguly et al, 2005)  no ortholog
 27F    Wnt10