2017-2018 Fall Kick-off Talk (Ron Zuckermann, LBNL)
Sequence-controlled peptoid polymers: folding and assembly into ordered nanostructures
Ronald N. Zuckermann
A fundamental challenge in materials science is to create synthetic nanoarchitectures that rival the structural complexity found in nature. A promising bioinspired approach is to synthesize sequence-defined polymer chains that fold into precise protein-like structures. In order to efficiently produce such information-rich polymer sequences, we use the automated solid-phase submonomer synthesis method to generate sequence-defined peptoid polymers up to 50 monomers in length. The method uses readily available primary amine synthons, allowing hundreds of chemically diverse sidechains to be cheaply introduced. We use this method, along with with computational modeling, to design, synthesize, assemble and engineer a variety of protein-mimetic nanostructures. Here we examine peptoid sequences that can form highly ordered supramolecular assemblies of nanosheets and nanotubes, and compare their molecular structures to the fundamental structures found in biology.