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Renee Reijo Pera, Ph.D.
Principal Investigator
reneer@stanford.eduRenee Reijo Pera, Ph.D.

Dr. Reijo Pera is the Director of the Human Embryonic Stem Cell Research and Education and a Professor of Obstetrics and Gynecology at Stanford University. Her research is aimed at understanding the genetics of human embryo growth and development and in characterizing the basic properties of human embryonic stem cells, especially their ability to differentiate to all cell types including germ cells. She has received numerous awards throughout her career and most recently was named Outstanding Faculty Mentor at UCSF in 2005 and one of the twenty Top Women On Leadership featured in Newsweek 2006. She received her Bachelor of Science degree from the University of Wisconsin (Superior), her doctoral degree from Cornell University in Ithaca, New York, and her postdoctoral training at the Whitehead Institute for BioMedical Research at the Massachusetts Institute of Technology in Cambridge, Massachusetts.

Click here to see Dr. Reijo Pera's scientific publications

Masae Ahmann
Intern - San Francisco State University
masaeahmann@yahoo.com

 

Erica Anderson
Research Assistant
erica.k.and@gmail.com

Previous Affiliations:

Cal Poly - San Luis Obispo, B.S. Cellular and Molecular Biology

San Jose State University, M.S. Biotechnology

Current Project:

We work with disease specific human embryonic stem cell (hESC) and induced pluripotent stem cell (iPSC) lines harboring various mutations in the FBN1 gene which causes Marfan Syndrome (MFS). We are working to compare normal and MFS cell lines following in vitro differentiation towards osteogenic and cardiovascular cell fates to shed light on the mechanisms underlying the disease and potentially lead to the development of in vitro assays suitable for high-throughput drug screens.

Interesting Facts/Hobbies:

I was born on an island in the Pacific Northwest, but I am now a California girl at heart. In my free time I love to read, go to shows, travel, and cook.

Publications

Blake Byers
Graduate Student - Bioengineering
blakehbyers@gmail.com

Department of Bioengineering

Previous Affiliations:

Duke University, B.S. Bioengineering and B.S. Economics

Current Project:

Modeling Parkinson's Disease with iPSCs and optical control of iPSC-derived neurons in-vivo

Interesting Facts/Hobbies:

Entrepreneurship, hydrating ATP, and rocking out with stem cells

Publications

Ashley EA, Ferrara R, King JY, Vailaya A, Kuchinsky A, He X, Byers B, Gerckens U, Oblin S, Tsalenko A, Soito A, Spin JM, Tabibiazar R, Connolly AJ, Simpson JB, Grube E, Quertermous T.. (2006). Network analysis of human in-stent restenosis. Circulation, 114(24):2644-54.

Shawn Chavez, Ph.D.
Postdoctoral Fellow
chavezs@stanford.edu

Ruth L. Kirschstein National Research Service Award (NRSA) Fellow (NIH/NICHD)

Previous Affiliations:

University of California - Santa Barbara, B.S. Biological Sciences & Howard hughes Medical Institute (HHMI) Fellow

Yale University, M.S./ Ph.D. Molecular, Cellular and Developmental Biology

University of California - San Francisco, Postdoctoral Scholar

Current Project:

Investigating the expression and function of particular DNA Methyltransferases (DNMTs) in mouse and human germ cell differentiation as well as the role of epigenetic mechanisms (DNA methylation and histone modifications) in mammalian pre-implantation development.

Interesting Facts/Hobbies:

5th generation native Californian that enjoys running, gardening and watching almost all sports, but does not like leading us in a song.

Publications

  • Aschkenazi, S., Straszewski, S., Verwer, K., Foellmer, H., Rutherford, T., Mor, G. Differential Regulation and Function of the Fas/FasL System in Human Trophoblast Cells. Biology of Reproduction 2002; 66: 1853-186.
  • Mor, G., Straszewski, S., Kamsteeg, M. The Role of the Fas/FasL System in Female Reproductive Organs: Survival and Apoptosis. Biochemical Pharmacology 2002; 64: 1305-1315.
  • Abrahams, V.M., Straszewski, S.L., Kamsteeg, M., Hanczaruk, B., Rutherford, T.J., Schwartz, P.E., Mor, G. Epithelial Ovarian Cancer Cells Secrete Functional Fas Ligand. Cancer Research 2003; 63: 5573-5581.
  • Abrahams, V.M., Straszewski, S.L., Kim Y.M., Romero R., Mor, G. Macrophages and apoptotic cell clearance during pregnancy. American Journal of Reproductive Immunology 2004; 51(4): 275–282.
  • Straszewski-Chavez, S.L., Abrahams, V.M., Funai, E.F., Mor, G. X-linked Inhibitor of Apoptosis (XIAP) Confers Human Trophoblast Cell Resistance to Fas-Mediated Apoptosis. Molecular Human Reproduction 2004; 10(1): 33-41.
  • Abrahams, V.M., Straszewski-Chavez, S.L., Guller, S., Mor, G. First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Molecular Human Reproduction 2004; 10(1): 55-63.
  • Abrahams, V.M., Bole-Aldo, P., Kim, Y.M., Straszewski-Chavez, S.L., Chaiworapongsa, T., Romero, R., Mor, G. Divergent Trophoblast Responses to Bacterial Products Mediated by Toll-Like Receptors. Journal of Immunology 2004; 173: 4286-4296.
  • Straszewski-Chavez, S.L., Abrahams, V.M., Mor, G. The Role of Apoptosis in Trophoblast Survival and Differentiation During Pregnancy. Endocrine Reviews 2005 26(7): 877-897.
  • Straszewski-Chavez, S.L., Visintin, I.P., Karassina, N., Los, G., Liston, P., Halaban, R., Mor, G. XAF1 mediates TNF- a -induced apoptosis and XIAP cleavage by acting through the mitochondrial pathway. Journal of Biological Chemistry 2007 282(17): 13059-13072. 
  • Chavez, S.L., Meneses, J.J., Nguyen, H.N., Kim, S.K. and Reijo Pera, R.A. Characterization of Six New Human Embryonic Stem Cell Lines (HSF-7, -8, -9. -10, -12 and -13) Derived Under Minimal-Animal Component Conditions. Stem Cells and Development 2008 17(3): 535-546.
  • Nicholas, C.R., Chavez, S.L., Baker, V.L., Reijo Pera, R.A. Instructing an embryonic stem cell-derived oocyte fate: lessons from endogenous oogenesis. Endocrine Reviews 2009 30(3): 264-283.
  • Straszewski-Chavez, S.L., Abrahams, V.M., Alvero, A.B., Aldo, P.B., Ma, Y., Guller, S., Romero, R., Mor, G. The Isolation and Characterization of a Novel Telomerase Immortalized First Trimester Trophoblast Cell Line, Swan 71. Placenta 2009 30(11): 939-948.
  • Straszewski-Chavez, S.L., Abrahams, V.M., Aldo, P.B., Romero, R., Mor, G. AKT controls first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression. Biology of Reproduction 2010 82(1): 146-152.
  • McElroy, S.L., Byrne, J.A., Chavez, S.L., Behr, B., Hsueh, A.J., Westphal, L.M., Reijo Pera, R.A. Parthenogenic Blastocysts Derived from Cumulus-free In Vitro Matured Human Oocytes. PLoS ONE 2010 5(6): e10979.

Lily Chen, Ph.D.
Visiting Professor
Lilychen@sfsu.edu

Previous Affiliations:

State University of New York - Buffalo, Ph.D. Microbiology

MIT Whitehead Institute & University of California -San Francisco, Postdoctoral fellow

San Francisco State University, Associate Professor, Dept. of Biology

Current Project:

My research focuses on parthogenesis, gene expression and regulation, and drug resistant mechanisms of microbial diseases. I am also heavily engaged in science education and the graduate program development in biotechnology and stem cell science

Interesting Facts/Hobbies:

Biking, running, and crafts (ceramics and stained glass)

Publications

  • Al-Nimri, S., Miller, W., Byrne, B., Guibert, G., and Chen, L. A unified approach to molecular epidemiology investigations: tools and patterns in California as a case study for endemic shigellosis. BMC Infectious Disease 9:184, 2009.
  • Kiang, D., Chou-Newbower, E., Yeh, E., Wold, L., Chen, L., Schnurr, D. An algorithm for the typing of enteroviruses and correlation to serotyping. J. Clinical Virology 45:334-340, 2009.
  • Das, C., Edgcomb, S.P., Peteranderl, R., Chen, L., and Frankel, A.D. Evidence for conformational flexibility in the Tat:TAR recognition motif of cyclin T1.Virology 318: 306-317, 2004.
  • Smith, C.A., Chen, L., and Frankel, A.D. Using peptides as models of RNA protein interactions.  Methods in Enzymology: RNA-ligand interactions, Part B: Molecular biology methods. Volume 318:423-438, 2000.
  • Tao, J., Chen, L., and Frankel, A.D. Dissection of the proposed base triple in HIV TAR RNA indicates the importance of the Hoogsteen interaction. Biochemistry  36: 3491-3495,  1997.
  • Puglisi, J.D., Chen, L., Blanchard, S., and Frankel, A.D. Solution structure of a Bovine Immunodeficiency Virus Tat-TAR peptide-RNA complex.  Science  270: 1200-1203,  1995.
  • Chen, L. and Frankel, A.D.  A peptide interaction in the major groove of RNA resembles protein interactions in the minor groove of DNA. Proceedings of the National Academy of Sciences of the United States of America  92: 5077-50812,  1995.
  • Chen, L. and Frankel, A.D. An RNA-binding peptide from Bovine Immunodeficiency Virus Tat protein recognizes an unusual RNA structure.  Biochemistry  33: 2708-2715,  1994.
  • Chen, L., Rekosh, D.M., and LoVerde, P.T.  Schistosoma mansoni  p48 eggshell protein gene: characterization, developmentally regulated expression, and comparison to the p14 eggshell protein gene.  Molecular and Biochemical Parasitology 52: 39-52, 1992.
  • LoVerde, P.T. and Chen, L. Schistosome female reproductive development.  Parasitology Today  7(11): 303-308, 1991.
  • Chen,  L., Wu,  L-L., Lee, N. and Tsai, W-C.  A simple method for performing yeast carbohydrate assimilation test.  Chinese Journal of Microbiology and Immunology 18(4): 72-77, 1985.  

Jun Cui, Ph.D.
Postdoctoral Fellow
juncui@stanford.edu

Previous Affiliations:

Cornell University, Ph.D. Genetics and Development

Dr. Mariana Wolfner Laboratory, Cornell : worked focused on regulatory polyadenylation of maternal mRNAs during oogenesis and egg activation in Drosophila

Current Project:

Interesting Facts/Hobbies:

Travel, Hiking, movies

Publications

  • Cui, J., Sackton, K. L., Horner, V. L., Kumar, K. E., and Wolfner, M.F., 2008 Wispy, the Drosophila homolog of GLD-2, is required duringoogenesis and egg activation. Genetics 178: 2017–2029

Antonia Dominguez
Graduate Student - Genetics
antoniadom@gmail.com

Department of Genetics

Previous Affiliations:

New Mexico State University, B.S. Biochemistry

Dr. Glenn Kuehn Laboratory, New Mexico State University

Current Project:

Characterization of Germ Cell Differentiation from Induced Pluripotent Stem Cells with Turner Syndrome.  The goal of the project is to develop a system that enables the use of gene complementation to identify genes located on the human X chromosome that require two copies for proper germ cell development.  

Interesting Facts/Hobbies:

Born and raised in the Land of Enchantment.  I keep a volleyball at my desk, just in case anyone want to play! Figuring out Tissue Culture music stem cells grow well to.

Publications

Jens Durruthy-Durruthy
Visiting Researcher
durruthy@stanford.edu

Previous Affiliations:

Technical University Berlin - Germany: Undergraduate/Graduate studies, Medical Biotechnology

University of North Carolina, Chapel Hill: Exchange year

Dr. Roland Lauster Laboratory, German Rheumatic Resarch Institute

Dr. Christian Jobin Laboratory, University of North Carolina

Dr. Emma Lundberg Laboratory, Royal Institute of Technology - Stockholm

Current Project:  

Interesting Facts/Hobbies:

I'm totally into sports. Especially, (beach)volleyball and track and field. Used to do professional dancing for 8 years but not anymore. Besides sports I do play the piano and if I find a bass guitar somewhere lying around take it and play on it, too.

Publications

Akshi Goyal
Intern - San Jose State University
akshigoyal@yahoo.com

Prachi Gujar
Research Assistant
pgujar@stanford.edu


Cindy Klein
Senior Lab Manager
cklein@stanford.edu

Previous Affiliations:

San Jose State University

Dr. Aaron Hsueh Laboratory - Stanford University : Sr Lab Manager for OB/GYN Dept

Current Project:

Interesting Facts/Hobbies:

I love to cook, bake, garden and travel as well as spend time with my family, especially the newest addition our grandson.  Most of our recent travels have been by motorcycle. I love the long cross country trips by motorcycle (my own bike).

Publications

Patrick Lee
Research Assistant
pclee15@stanford.edu

Previous Affiliations:

University of California - Berkeley, B.S. Neurobiology

Dr. Becket Feierbach Laboratory - Genentech, Inc. : Project focused on identifying specific chemokine receptors as a mode of entry for Human Cytomegalovirus (HCMV)

Dr. Marie-Francoise Chesselet Laboratory - University of California, Los Angeles : neuronal behavioral studies of mice with Parkinson's Disease

Current Project:  

My main research project is to explore the reprogramming process of skin fibroblasts derived from patients with Parkinson's Disease into induced pluripotent stem cells (iPSCs), employing a lentiviral transfection of the four transcription factors.

Interesting Facts/Hobbies:

I'm from Santa Monica, CA. Played baseball for 10 years, but horrible at ping pong and tennis . Also, I can't function and do experiments in the morning without coffee.

Publications

Sohyun Lee McElroy, Ph.D.
Postdoctoral Fellow
sohyun@stanford.edu

Previous Affiliations:

Seoul National University - Korea, B.S. Veterinary Medicine

Seoul National University - Korea, M.S. / Ph.D. Reproductive Biology

Iowa State University

University of California - San Francisco - Postdoctoral Fellow

Current Project:  

The reprogramming of human oocytes by somatic cell nuclear transfer and female germ cell specification and and differentiation from human embryonic as well as induced pluripotent stem cells

Interesting Facts/Hobbies:

Like college football, especially Ohio State University and love spicy foods

Publications

  • Kim S, Lee SH, Kim DY, Kang SK, Lee BC, Hwang WS. Effect of macromolecules supplemented to NCSU23 and PZM culture media on in vitro development of porcine embryos. Korean J Embryo Transfer 2003;18:35-41.
  • 2. Lee SH, Kim DY, Nam DH, Hyun SH, Lee GS, Kim HS, Lee CK, Kang SK, Lee BC, Hwang WS. Role of messenger RNA expression of platelet activating factor and its receptor in porcine in vitro-fertilized and cloned embryo development. Biol Reprod 2004;71:919-925.
  • Lee SH, Zhao S, Recknor JC, Nettleton D, Orley S, Kang SK, Lee BC, Hwang WS, Tuggle CK. Transcriptional profiling using a novel cDNA array identifies diferential gene expression during porcine embryo elongation. Mol Reprod Dev 2005;71:129-139.
  • Kim S, Lee SH, Kim JH, Jeong YW, Hashem MA, Koo OJ, Park SM, Lee EG, Hossein MS, Kang SK, Lee BC, Hwang WS. Anti-apoptotic effect of insulin-like growth factor (IGF)-I and its receptor in porcine preimplantation embryos derived from in vitro fertilization and somatic cell nuclear transfer. Mol Reprod Dev 2006;73:1523-1530.
  • Lee E, Lee SH, Kim S, Jeong YW, Kim JH, Koo OJ, Park SM, Hashem MA, Hossein MS, Son HY, Lee CK, Hwang WS, Kang SK, Lee BC. Analysis of nuclear reprogramming in cloned miniature pig embryos by expression of Oct-4 and Oct-4 related genes. Biochem Biophys Res Commun. 2006;348:1419-1428.
  • Kim JH, Lee SH, Kim S, Jeong YW, Koo OJ, Hashem MD, Park SM, Lee EG, Hossein MS, Kang SK, Lee BC, Hwang WS. Embryotrophic effects of ethylenediaminetetraacetic acid and hemoglobin on in vitro porcine embryos development. Theriogenology 2006;66:449-455.
  • McElroy SL, Kim JH, Kim S, Jeong YW, Koo OJ, Lee EG, Park SM, Abul Hashem MD, Hossein MS, Jang G,Jeon HY, Kang SK, Lee BC, Hwang WS. Nuclear transfer condition affect blastocyst formation and messenger RNA expression patterns in cloned porcine embryos. Theriogenology 2008;69:416-425.
  • McElroy SL, Kee K, Tran N, Menses J, Giudice LC, Reijo-Pera RA. Assessment of developmental competence of immature and abnormally-fertilized human oocytes in nuclear transfer. Reprod Biomed Online
  • McElroy SL, Byrne J, Chavez SL, Behr B, Hsueh AJ, Reijo Pera RA. Parthenogenic blastocysts from cumulusfree in vitro matured human oocytes using ovarian paracrine/autocrine factors. PLoS One 2010;5:e10979.
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Melanie Marchand, Ph.D.
Postdoctoral Fellow
mmelanie@stanford.edu

Previous Affiliations:

Ecole Normale Superieure de Lyon - France, Ph.D. Developmental Biology

Dr. Paul Satvier Laboratory, French National Institute of Health : ESCs and pancreatic development

TRANSAT - France, Development of cellular models studying Diabetes

Dr. Linda Giudice Lab, University of California - San Francisco : ESCs and trophoblast development

Current Project:

Pluripotent Stem Cells for studying cardiovascular development and diseases

Interesting Facts/Hobbies:

Travels, volleyball, cinema

Publications

  • Mouse ES cells over-expressing the transcription factor NeuroD1 show increased differentiation towards endocrine lineages and insulin-expressing cells. Marchand M, Schroeder IS, Markossian S, Skoudy A, Nègre D, Cosset FL, Real P, Kaiser C, Wobus AM, Savatier P. Int J Dev Biol. 2009; 53 (4): 569-78

  • Viral-mediated coexpression of Pdx1 and p48 regulates exocrine pancreatic differentiation in mouse ES cells. Rovira M, Jané-Valbuena J, Marchand M, Savatier P, Real FX, Skoudy A. Cloning Stem Cells. 2007; 9 (3): 327-38

  • Cell cycle features of primate embryonic stem cells. Fluckiger AC, Marcy G, Marchand M, Négre D, Cosset FL, Mitalipov S, Wolf D, Savatier P, Dehay C. Stem Cells. 2006; 24 (3): 547-56

  • Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. Moriscot C, de Fraipont F, Richard MJ, Marchand M, Savatier P, Bosco D, Favrot M, Benhamou PY. Stem Cells. 2005; 23 (4): 594-603

  • Use of the Kleihauer test to detect fetal erythroblasts in the maternal circulation. Martel-Petit V, Petit C, Marchand M, Fleurentin A, Fontaine B, Miton A, Lemarie P, Philippe C, Jonveaux P. Prenat Diagn. 2001; 21 (2): 106-11

Devi Paulvannan
Visiting Researcher
pdevi@stanford.edu

Previous Affiliations:

University of California, Los Angeles - B.S. Microbiology, Immunology, Genetics

San Francisco State University - Graduate Student, Microbiology

Current Project:

Interesting Facts/Hobbies:

soccer, field hockey

Publications

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Jose V. Medrano Plaza
Graduate Student
jomepla@stanford.edu

Previous Affiliations:

Universitat de Valencia - Spain, B.S. Biological Sciences / M.S. Reproductive Medicine

Dr. Carlos Simon Laboratory - Valencia: work focused on differentiation hESCs to germ cells. Professional skills focused in embryology, molecular and cellular biology of the human germ line

Current Project:

Fertility problems usually are due to problems in gametogenesis. Also, very little is knowna bout human germ line development because of the impossibility of performing in vivo developmental studies. My research objecive is to establish an in vitro model for germ line differentiation from human pluripotent stem cells in order to study which are the key regulators of germ line development and how they work. Specifically, I am interested in the study of highy conserved RNA-binding proteins involved in this process.

Interesting Facts/Hobbies:

I like reading, movies and videogames, specially RPGs. Also I like sports such soccer and I love motor sports (Formula One and MotoGP). Furthermore, I like to play extreme sports such skydiving, jumping....

Publications

  • Medrano JV, Marqués-Marí AI, Aguilar CE, Riboldi M, Garrido N, Martínez-Romero A, Gil-Salom M, Simón C. Comparative analysis of germ cell markers c-KIT, SSEA-1 and VASA in testicular biopsies from secretory versus obstructive azoospermia. Mol Hum Reprod. 2010 May 27.
  • Aguilar C, Poo ME, Gomez E, Galan A, Sanchez E, Marques-Mari A, Ruiz V, Medrano J, Riboldi M, Enseñat-Waser R, Valbuena D, Simon C. Derivation, Characterization, Differentiation and Registration of Seven Human Embryonic Stem Cell Lines (VAL-3, -4, -5, -6M, -7, -8, and -9) on Human Feeder. In Vitro Cell Dev Biol Anim. 46(3-4):317-26.
  • Marques-Mari AI, Lacham-Kaplan O, Medrano JV, Simon C. Differentiation of Germ Cells and Gametes from Stem Cells. Hum Reprod Update. 2009; 1: 1–12.
  • Marques-Mari AI, Medrano JV, Simon C. Differentiating Gametes from Stem Cells. In H. Baharvand (ed.), Trends in Stem Cell Biology and Technology. Humana press. 2009; 137-147.
  • Cristóbal Aguilar Gallardo, Sandra García-Herrero, José Vicente Medrano, Marco Antonio B. Melo. Pronóstico reproductivo de las malformaciones müllerianas. Prog Obstet Ginecol. 2008; 51 (12): 721-36.
  • G. Rodrigo, A. Montagud, A. Aparici, M.C. Aroca, M. Baguena, J. Carrera, C. Edo, P. Fernandez-de-Cordoba, A. Ferrando, G. Fuertes, D. Gimenez, C. Mata, J.V. Medrano, C. Navarrete, E. Navarro, J. Salgado, P. Tortosa, J. Urchueguia, A. Jaramillo. Vanillin cell sensor. IET Synth. Biol. 2007; 1 (1–2): 74–78.

Juanito Meneses
Specialist
meneses@stanford.edu

Publications

  • Pfendler, Kristina C., Catuar, Carmina S., Meneses, Juanito J., Pedersen, Roger A. Overexpression of Nodal Promotes Diffrerentiation of Mouse Embryonic Stem Cells into Mesoderm and Endoderm at the Expense of Neuroectoderm FormationStem Cells and Development.2005 April, 14 (2) 162-72
  • Li, L., Salido, E., Zhou, Y.,Bhattacharyya, S., Yannone, S.M. Dunn, E., Meneses, J., Feeney, A.J., Cowan, M.J. Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recommendation that is partially corrected by bone marrow transplantation. Journal of Immunology 2005 Feb. 15; 174(4): 2420-8.
  • Wang, Z., Zhai, W., Richardson, J.A., Olson, E.N., Meneses, J.J., Firpo, M.T., Kang, C., Skarnes, W.C., Tijan, R. Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Genes and Development 2004, Dec. 15; 18(24): 3103-16
  • Bodnar, Megan S., Meneses, Juanito J., Rodriguez, Ryan T., Firpo, Meri T. Propagation and Maintenance of Undifferentiated Human Embryonic Stem Cells. Stem Cells and Development June 2004, Vol. 13, No. 3:243-253
  • Boucher, D.M, Schaffer, M., Deissler, K., Moore, C.A., Gold, J.D., Burdsal, C.A., Meneses, J.J., Pedersen, R.A., Blum, M. Goosecoid expression represses Brachyury in embryonic stem cells and affects craniofacial development in chimeric mice. International Journal of Developmental biology 2000 Apr, 44(3): 279-88.

Smruti Phandis, Ph.D.
Postoctoral Fellow
smruti@stanford.edu

Cyril Ramathal, Ph.D.
Postdoctoral Fellow
cyrilr@stanford.edu

Previous Affiliations:

University of Illinois - Urbana-Champaign, Ph.D. Cell & Developmental Biology

Dr. Milan Bagchi Laboratory - University of Illinois : Project focused on the role of steroid hormones in regulating gene function during endometrial remodelling and implantation.

Current Project:  

The goal of my research is to explore the requirement of the AZFc (Azoospermia Factor C) genes for human sperm production. It is believed that the functions of the genes expressed from this large (5-10 MB) region of the Y chromosome are highly important for normal sperm production. I am utilizing reprogramming strategies to generate patient-specific pluripotent stem cells from infertile men who carry deletions of the AZFc genes and derive germ cell precursors (PGC-like cells) from these cells using genetic approaches. Using genetic complementation analysis, I will try to dissect the requirement of AZFc genes for nomrla sperm production and function. The intention of this strategy is twofold: First, to recover normal sperm production from the somatic skin cells of patients who carry an AZFc deletion and cannot make their own sperm. Second, to design and implement a strategy that may translate to other models of gene-based human pathologies wherein patient-derived cells can be reprogrammed and genetically altered for use in human developmental genetic analysis.

Interesting Facts/Hobbies:

Soccer, Football, Music

Publications

  • Ramathal, C., Bagchi, I., Bagchi, M., 2009. “Lack of CCAAT Enhancer Binding Protein Beta (C/EBPβ) in uterine epithelial cells impairs estrogen-induced DNA replication, induces DNA damage response pathways and promotes apoptosis” Mol. Cell. Biol. 30: 1607-1619
  • Ramathal, C., Bagchi, I., Taylor, R.M., Bagchi, M. 2009. “Decidualization: Of Mice and Men”. Sem. Reprod. Med. 28: 17.

Sonya Schuh-Huerta, Ph.D.                                                    
Postdoctoral Fellow
sonyas1@stanford.edu

Previous Affiliations:

University of California - Riverside / Humboldt State University, B.S. Marine Biology & Zoology

University of Washington - Ph.D. Physiology & Biophysics

Current Project:  

Investigations into the genes and genetic variants associated with follicle (egg) number in women, and the roles of other enviornmental, ethic, physical, and hormonal factors in the inevitable process of follicle loss and diminished fertility that occurs throughout life

Interesting Facts/Hobbies:

Art - of many forms, making jewlry, mineralogy (rock & fossil hunting), teaching, dancing, kickboxing, going to the beach, and just chillin'. Born and raised in Southern California, my parents have both been teachers, and all my siblings are either in the science and medical field. Favorite quote: "Art is the Queen of all sciences communicated knowledge to all the generations of the world." Leonardo Da Vinci

Publications

  • Krasnow, S.M., Fraley, G.S., Schuh, S.M., Baumgartner, J.W., Clifton, D.K., Steiner, R.A. (2003).  A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse.Endocrinology, 144(3):813-822.
  • Carlson, A.E, Quill, T.A., Westenbroek, R.E., Schuh, S.M., Hille, B., Babcock, D.F. (2005).  Identical phenotypes of CatSper1 and CatSper2 null sperm. J Biol Chem, 280(37):32238-44.
  • Xie, F., Garcia, M.A., Carlson, A.E., Schuh, S.M., Babcock, D.F., Jaiswal, B.S., Gossen, J., Esposito, G., van Duin, M., Conti, M. (2006).  Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization.  Dev Biol, 396(2):353-62.
  • Schuh, S.M., Carlson, A.E., McKnight, G.S., Conti, M., Hille, B., Babcock, D.F. (2006).  Signaling pathways for modulation of mouse sperm motility by adenosine and catecholamine agonists.  Biol Reprod, 74:492-500.
  • Schuh, S.M., Hille, B., Babcock, D.F. (2007)Adenosine and catecholamine agonists speed the flagellar beat of mammalian sperm by a non-receptor-mediated mechanism.  Biol Reprod, 77(6):960-9.
  • Rosen MP, Sternfeld B, Schuh-Huerta SM, Reijo Pera RA, McCulloch CE, Cedars MI (2010). Antral Follicle Count – absence of significant midlife decline. Fertil & Steril, in press.
  • Rosen MP, McCulloch CE, Schuh-Huerta SM, Murphy R, McConnell D, Reijo Pera RA, Cedars MI (2010). A characterization of ovarian reserve markers with age. Submitted, J Clin Endo Metab   

Vittorio Sebastiano, Ph.D.
Research Manager, Center for Human Embyronic Stem Cell Research and Education
vsebast@stanford.edu

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Ninuo Xia, Ph.D.
Postdoctoral Fellow
nxia007@stanford.edu

Previous Affiliations:

University of California - Riverside, Ph.D. Biochemistry and Molecular Biology

Current Project:

Derivation and comparative analysis of human pluripotent ESCs, iPSCs, and SSCs 

Interesting Facts/Hobbies:

I'm a soccer player!

Publications
  • Ninuo Xia , Silvia Sauer, and Frank Sauer. The long, non-coding RNA Scirocco (SCIR) mediates activation and repression of HOXA1 and HOXA2 transcription by regulating the association of the epigenetic regulators MLL and PRC2 with bivalent chromatin in human embryonic cancer cells. Reviewing in progress.
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RRP Lab Members

Masae Ahmann
Erica Anderson
Blake Byers
Shawn Chavez, Ph.D.
Jun Cui, Ph.D.
Lily Chen, Ph.D.
Antonia Dominguez
Jens Durruthy-Durruthy
Akshi Goyal
Prachi Gujar
Cindy Klein
Patrick Lee
Sohyun Lee McElroy, Ph.D.
Melanie Marchand, Ph.D.
Devi Paulvannan
Jose V. Medrano Plaza
Juanito Meneses
Smruti Phadnis, Ph.D.
Cyril Ramathal, Ph.D.
Sonya Schuh-Huerta, Ph.D.
Renee Reijo Pera, Ph.D.
Vittorio Sebastiano, Ph.D.
Ninuo Xia, Ph.D.

 

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