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Publications (1997 to present)
Fischer, K.J., Jacobs, C.R., Levenston, M.E., Carter, D.R.,
Observations of Convergence and Uniqueness of Node-Based
Remodeling Simulations, Annals of Biomedical Engineering,
25:261-268, 1997.
Jacobs, C.R., Simo, J.C., Beaupré, G.S., Carter, D.R.,
Adaptive Bone Remodeling Incorporating Simultaneous
Density and Anisotropy Considerations, Journal of Biomechanics,
30:603-613, 1997.
Yellowley, C.E., Jacobs, C.R., Li, Z., Zhou, Z., Donahue, H.J.,
Effects of Fluid Flow on Intracellular Calcium in Bovine
Articular Chondrocytes, American Journal of Physiology,
273:C30-C36, 1997.
Juliano, P.J., Yu, J.R., Schneider, D.J., Jacobs, C.R.,
Evaluation of Fracture Predilection in the Calcaneus After
External Fixator Pin Removal, Journal of Orthopaedic Trauma,
11:430-434, 1997.
Jacobs, C.R. and Eckstein, F., Computer
Simulation of Subchondral Bone Adaptation to Mechanical Loading in an
Incongruous Joint, The Anatomical Record, 249:317-326, 1997.
Fischer, K.J., Jacobs, C.R., Levenston, M.E., Cody, D.D., and
Carter, D.R., Bone Load Estimation for the Proximal Femur
Using Single Energy Quantitative CT Data, Computer Methods in
Biomechanics and Biomedical Engineering, 1(3):233-245, 1998.
Fedok, F.G., Van Kooten, D.W., DeJoseph, L.M., Sobota, B., Levin, R.J.,
Jacobs, C.R., An Analysis of Plating Techniques and Plate Orientation in
Repair of Mandibular Angle Fractures: An in Vitro Study, Laryngoscope,
108:1218-1224, 1998.
Jacobs C.R., Yellowley C.E., Davis B.R., Zhou Z., Donahue H.J.,
Differential Effect of Steady versus Oscillating Flow on
Bone Cells. Journal of Biomechanics, 31:969-976, ESB Research
Award 1998.
Eckstein, F., Merz, B., Schön M., Jacobs, C.R., Putz, R.,
Tension and Bending, but not Compression Alone Determine the Functional
Adaptation of Subchondral Bone in Incongruous Joints: Anatomy and
Embryology, 199:85-97, 1999.
Barr J.D., Hoffman E.J., Davis B.R., Edgar K.A., Jacobs C.R.,
Microcatheter Adhesion of Cyanoacrylates: Comparison of Normal Butyl
Cyanoacrylates to 2-Hexyl Cyanoacrylates. Journal of Vascular and
Interventional Radiology, 10:165-168, 1999.
Segal L.S., Schneider M.D., Berlin J.M., Bruno A., Davis B.R., Jacobs
C.R., The Contribution of the Ossific Nucleus to the Structural Stiffness
of the Capital Femoral Epiphysis: A Porcine Models for DDH. Journal of
Pediatric Orthopaedics, 19:433-437, 1999.
Black K.P., Schneider D.J., Yu J.R., Jacobs C.R., Biomechanics of
the Bankart Repair: The Relationship Between Glenohumeral Translation and
Labral Fixation Site. American Journal of Sports Medicine,
27:339-344, 1999.
Yellowley, C.E., Jacobs, C.R., Donahue H.J., Mechanisms
Contributing to Fluid Flow-Induced Ca2+ Mobilization in Articular
Chondrocytes: Journal of Cellular Physiology, 180:402-408, 1999.
Fernandes P., Rodrigues H., Jacobs C.R., A Model of Bone
Adaptation Using a Global Optimisation Criterion Based on the Trajectorial
Theory of Wolff. Computer Methods in Biomechanics and Biomedical
Engineering, 2:125-138, 1999.
Jacobs, C.R., Davis, B.R., Rieger, C.J., Francis, J.J., Saad, M.,
Fyhrie, D.P., The Impact of Boundary Conditions and Mesh Size on the Accuracy
of Cancellous Bone Tissue Modulus Determination Using Large Scale Finite
Element Modeling: Journal of Biomechanics, 32:1159-1164, 1999.
Fischer K.J., Jacobs C.R., Levenston M.E., Cody D.D., Carter
D.R., Proximal Femoral Density Patterns are Consistent with Bicentric Joint
Loads: Computer Methods in Biomechanics and Biomedical Engineering,
2: 271-283, 1999.
Yellowley, C.E., Jacobs, C.R., Zhou, Z., Li, Z., Donahue, H.J.
Functional Gap Junctions Between Osteocytic and Osteoblastic Cells: Journal
of Bone and Mineral Research, 15:209-217, 2000.
Malecki, E.A., Buhl, K.M., Beard, J.L., Jacobs, C.R., Connor,
J.R., Donahue, H.J., Bone Structural and Mechanical Properties are Affected by
Hypotransferrinemia but not by Iron Deficiency in Mice: Journal of Bone and
Mineral Research, 15:271-277, 2000.
Jacobs, C.R., Yellowley, C.E., Nelson, D.R., Donahue, H.J., A
Novel Application of Rainflow Cycle Counting to Time-Varying Biophysical Time
Data, Computer Methods in Biomechanics and Biomedical Engineering,
3:31-40, 2000.
Jacobs, C.R., The Mechanobiology of Cancellous Bone Structural
Adaptation, Journal of Rehabilitation Research and Development,
37:209-216, 2000.
Lesch, M.L., Schneider, D.J., Deol, G., Davis, B.R., Jacobs,
C.R., Pellegrini, V.D., The Consequences of Anterior Femoral Notching in
Total Knee Arthroplasty: A Biomechanical Study, Journal of Bone and Joint
Surgery, 82-A:1096-1101, 2000.
You, J., Yellowley, C.E., Donahue, H.J., Jacobs, C.R., Substrate
Deformation Levels Associated With Routine Physical Activity Are Less
Stimulatory to Bone Cells Relative to Loading-Induced Oscillatory Fluid Flow,
Journal of Biomechanical Engineering, 122:387-393, 2000.
Edlich, M.J., Jacobs, C.R., Yellowley, C.E., Donahue, H.J.,
Oscillating Fluid Flow Regulates Calcium Concentration in Bovine Articular
Chondrocytes, Journal of Biomechanics, 34:59-66, 2000.
Kurokouchi, K., Jacobs, C.R., Donahue, H.J., Oscillating Fluid
Flow Inhibits TNF-a-Induced NF-kB Activation via an IkB Kinase
Pathway in Osteoblast-Like UMR106 Cells. Journal of Biological
Chemistry, 276: 13499-13504, 2001.
You, J., Reilly, G.C., Zhen, X., Yellowley, C.E., Chen Q., Donahue,
H.J., Jacobs, C.R., Osteopontin Gene Regulation by Oscillatory Fluid
Flow via Intracellular Calcium Mobilization and Activation of Mitogen-Activated
Protein Kinase in MC3T3-E1 osteoblasts. Journal of Biological Chemistry,
276:13365-13371, 2001.
Journal Articles
Publications in the Journal of Rehabilitation Research and
Development
Jacobs CR. Large-scale finite element solutions on workstations class
computers. J Rehab Res Dev, submitted, 2004.
Peer-Reviewed Articles
Godin, L.M., Suzuki, S., Jacobs, C.R., Donahue, H.J., Donahue, S.W.,
Mechanically induced intracellular calcium waves in osteoblasts demonstrate
calcium fingerprints in bone cell mechanotransduction. Biomechanics and
Modeling in Mechanobiology, Nov 6, Epub, 2006.
Kim, C., You, L., Yellowley, C.E., Jacobs, C.R., Oscillatory Fluid Flow
Induced Shear Stress Decreases Osteoclastogenesis Through Regulation of RANKL
and OPG. Bone, 39:1043-1047, 2006.
Malone, A.M., Batra, N.N., Shivaram, G, Kwon, R, You, L., Kim, C.,
Rodriguez, J, Jair, K. Jacobs, C.R., The Role of the Actin Cytoskeleton in
Oscillatory Fluid Flow Induced Signaling in MC3T3-E1 Osteoblasts. American
Journal of Physiology-Cell, Jan 24, Epub, 2007.
Rubin, J., Rubin, C., Jacobs, C.R., Mechanical signaling in bone. Gene,
367:1-16, 2006. Shin C, Chaudhari A, Andriacchi T: The influence of
deceleration forces on ACL strain during single leg landing: a simulation
study. Journal of Biomechanics, (Epub ahead of print, June 22, 2006).
Batra NN, Li YJ, Yellowley CE, You L, Malone A, Kim C, and Jacobs CR:
Effects of Short-term Recovery Periods on Fluid Induced Signaling in
Osetoblastic Cells. Journal of Orthopaedic Research,
38:1909-1917, 2005.
Offley SC, Guo TZ, Wei T, Clark DJ, Vogel H, Lindsey DP, Jacobs CR, Yao
W, Lane, NE, and Kingery WS: Capsaicin-sensitive Sensory Neurons Contribute to
the Maintenance of Trabecular Bone Intregrity, Journal of Bone and Mineral
Research 20:257-67, 2005.
Malone AM, Narain R, and Jacobs CR: Biomechanical Regulation of
Mesenchymal Stem and Progenitor Cells and the Implications for Regenerative
Medicine. Current Opinion in Orthopaedics, 16:363-367, 2005.
Alford AI, Yellowley CE, Jacobs CR, Donahue HJ. Increases in cytosolic
calcium, but not fluid flow, affect aggrecan mRNA levels in articular
chondrocytes. J Cellular Biochem, 90:938-944, 2003.
Edlich M, Yellowley CE, Jacobs CR, Donahue HJ. Cycle number and waveform
of fluid flow affect bovine articular chondrocytes. Biorheology,
41:315-22, 2004.
Guo TZ, Offley SC, Boyd EA, Jacobs CR, Kingery WS. Substance P Signaling
contributes to the vascular and nociceptive abnormalities observed in a tibial
fracture rat model of complex regional pain syndrome type I. Pain,
108:95-107, 2004.
Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. The sensitivity of
tibiofemoral contact pressure to the size and shape of the lateral and medial
menisci. J Orthop Res, 22: 807-814, 2004.
Haut Donahue TL, Genetos DC, Jacobs CR, Donahue HJ, Yellowley CE.
Annexin V disruption impairs mechanically-induced calcium signaling in
osteoblastic cells. Bone, 35: 656-663, 2004.
Haut Donahue TL, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR.
Mechanosensitivity of bone cells to oscillating fluid flow-induced shear stress
may be modulated by chemotransport. J Biomech, 36: 1363-71, 2003.
Kingery WS, Offley SC, Guo TZ, Davies MF, Clark JD, Jacobs CR. A
substance P receptor (NK1) antagonist enhances the widespread osteoporotic
effects of sciatic nerve section. Bone, 33:927-936, 2003.
Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE, Jacobs CR.
Oscillatory fluid flow affects human marrow stromal cell proliferation and
differentiation. J Orthop Res, 22: 1283-1289, 2004.
Reilly GC, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Fluid flow
induced PGE2 release by bone cells is reduced by glycocalyx degradation whereas
calcium signals are not. Biorheology, 40:591-603, 2003.
Alford AI, Jacobs CR, Donahue HJ. Oscillating fluid flow regulates gap
junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP
kinase-dependent mechanism. Bone, 33: 64-70, 2003.
Buhl KM, Jacobs CR, Turner RT, Evans GL, Farrell PA, Donahue HJ.
Parallel changes in extracellular matrix protein gene expression, bone
formation, and biomechanical properties in aging rat bone. J Musculoskel
Res, 6: 157-169, 2002.
Donahue SW, Donahue HJ, Jacobs CR. Osteoblastic cells have refractory
periods for fluid-flow-induced intracellular calcium oscillations for short
bouts of flow and display multiple low-magnitude oscillations during long-term
flow. J Biomech, 36: 35-43, 2003.
Haut-Donahue TL, Rosenberg G, Jacobs CR, Weiss WJ. Finite element
analysis of stresses developed in blood sacs of a pusherplate blood pump.
Computer Methods Biomech Biomed Eng, 6: 7-15, 2003.
Haut-Donahue TL, Hull ML, Rashid MM, Jacobs CR. How the stiffness of
meniscal attachments and meniscal material properties affect tibio-femoral
contact pressure computed using a validated finite element model of the human
knee joint. J Biomech, 36: 19-34, 2003.
Saunders MM, Schwentker EP, Kay DB, Bennett GL, Jacobs CR, Verstraete
MC, Njus GO. Finite element analysis as a tool for parametric prosthetic foot
design and evaluation. Technique development in the solid ankle cushioned heel
(SACH) foot. Computer Methods Biomech Biomed Eng, 6: 75-87, 2003.
Saunders MM, You J, Zhou Z, Li Z, Yellowley CE, Kunze EL, Jacobs CR,
Donahue HJ. Fluid flow-induced prostaglandin E2 response of osteoblastic ROS
17/2.8 cells is gap junction-mediated and independent of cytosolic calcium.
Bone, 32: 350-356, 2003.
You J, Jacobs CR, Steinberg TH, Donahue HJ. P2Y purinoceptors are
responsible for oscillatory fluid flow induced intracellular calcium
mobilization in osteoblastic cells. J Biol Chem, 277: 48724-729, 2002.
Donahue SW, Jacobs CR, Donahue HJ. Flow-induced calcium oscillations in
rat osteoblastic cells are age, loading frequency, and shear stress dependent.
Amer J Physiol, 281: C1635-1641, 2001.
Fernandes PR, Folgado J, Jacobs CR, Pellegrini V. A contact model with
ingrowth control for bone remodelling around cementless stems. J
Biomech, 35: 167-176, 2002.
Haut TL, Hull ML, Rashid MM, Jacobs CR. A finite element model of the
human knee joint for the study of tibio-femoral contact. J Biomech Eng,
124: 273-280, 2002.
Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. How the stiffness of
meniscal attachments and meniscal material properties affect tibio-femoral
contact pressure computed using a validated finite element model of the human
knee joint. J Biomech, 36: 19-34, 2003.
Saunders MM, You J, Trosko JE, Yamasaki H, Li Z, Donahue HJ, Jacobs CR.
Gap junctions and fluid flow response MC3T3-E1 cells. Amer J Physiol,
281: C1917-1925, 2001.
Jacobs CR. The mechanobiology of cancellous bone structural adaptation.
J Rehab Res Dev, 37: 209-216, 2000.
http://www.vard.org/jour/00/37/2/jacob372.htm
Buhl KM, Jacobs CR, Turner RT, Evans GL, Farrel PA, Donahue HJ. Aged
bone displays an increased responsiveness to low-intensity resistance exercise.
J Appl Physiol, 90: 1359-1364, 2001.
Kurokouchi K, Jacobs CR, Donahue HJ. Oscillating fluid flow inhibits
TNF-a-induced NF-kB activation via an IkB kinase pathway in osteoblast-like
UMR106 cells. J Biol Chem, 276: 13499-13504, 2001.
Moulton MJR, Parentis MA, Kelly MJ, Jacobs CR, Naidu SH, Pellegrini VD.
Influence of metacarpophalangeal joint position on basal joint-loading in the
thumb. J Bone Joint Surg, 83-A: 709-716, 2001.
You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR.
Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium
mobilization and activation of mitogenactivated protein kinase in MC3T3-E1
osteoblasts. J Biol Chem, 276: 13365-13371, 2001.
In Review - 2006
Sabsovich, I., Clark, D.J., Liao, G., Peltz, G., Lindsey, D.P, Jacobs,
C.R., Yao, W., Guo, T.Z., Kingery, W.S., Bone microstructure and its associated
genetic variability in 12 inbred mouse strains: uCT study and in silico genome
scan, Submitted, Bone.
Wang, L., Zhao, R., Shi, X., Wei, T., Halloran, B.P., Clark, D.J.,
Jacobs, C.R., Kingery, W.S., Substance P regulates osteogenic activity of mouse
bone marrow stromal cells, Submitted, Bone.
You, L., Temiyasathi, S., Lee, P., Kim, C., Tummala, P., Yao, W.,
Kingery, W.S., Jacobs, C.R., Osteocytes as mechanosensors in the inhibition of
bone resorption due to mechanical loading. Bone, Submitted.
Abstracts - 2006
Jacobs C.,You, J., Reilly, G., Batra, N., Li, Y., Malone, A.,
Themiyasathit, S., Tang, J., Stearns, T., Anderson. C., Cellular
Mechanotransduction in Bone: Moving Towards a Molecular Mechanism. European
Cells and Materials Journal, 8:S3, p. 8, July 2006.
Kwon, R.Y., Anyeni, O.A., Jacobs, C.R., Mechanics of Deformation of
Osteoblastic Cells Exposed to Steady and Oscillatory Fluid Flow.
Transactions of the Orthopaedic Research Society, p. 129, March 2006.
Kwon, R.Y., Ayeni, O.A., Jacobs. C.R., Investigating the Mechanics of
Fluid Flow Induced Deformation in Bone Cells. Proc Soc Physical Regulation
in Medicine and Biology, p. 43, January, 2006.
Litzenberger, J.B., Tummala, P., Powell, C., Jacobs. C.R., Inhibition of
Beta-1 Integrin Signaling in Bone Cells Decreases Mechanosensitivity.
Transactions of the Orthopaedic Research Society, p. 1023, March 2006.
Malone A.M., Anderson, C.T., Tummala P., Stearns, T., Jacobs. C.R., Are
Primary Cilia Mechanosensory Organelles in Bone Cells? Proc Soc Physical
Regulation in Medicine and Biology, p. 50, January, 2006.
Malone, A.M., Cheng, Beam, M., Tummala, P., Jacobs, C.R., Fak Mediated
ERK ½ Phosphorylation with Exposure to Oscillatory Fluid Flow.
Transactions of the Orthopaedic Research Society, p. 1022, March 2006.
You, L., Temiyasathit, C., Jacobs. C., Osteocytes are Mechanosensors in
the Inhibition of Bone Resorption due to Mechanical Loading. Proc Soc
Physical Regulation in Medicine and Biology, p. 56 January, 2006.
You, L., Temiyasathit, C., Lee, P., Kim, C.H., Tummala, P., Yao, W.,
Kingery W., Jacobs. C., Osteocytes as Mechanosensors in the Inhibition of Bone
Resorption due to Mechanical Loading. Transactions of the Orthopaedic
Research Society, p. 382, March 2006.
Conference Presentations and Abstracts - Prior to 2006
Schwenke T, Wimmer M, Schneider E, Sumner D, Rosenberg A, Andriacchi T,
Jacobs J. Joint moments affect tibial polyethylene failure in TKA. Am
Physical Therapy Assoc Comb Sects Mtg, San Francisco, CA, Mar, 2004.
Wimmer M, Moisio K, Genge R, Rosenberg A, Jacobs J, Andriacchi T,
Martell. Hip joint moments predict polyethylene wear in total hip arthroplasty,
Orthop Res Soc Conf, San Francisco, CA, Mar, 2004.
Batra N, Li YJ, Jacobs CR. Effect of short term recovery periods on
fluid flow induced calcium oscillations in MC3T3-E1 osteoblastic cells.
Trans Orthop Res Soc, 28: 129, 2003.
Batra NN, Li YJ, Yellowley CE, You L, Jacobs CR. Short term recovery
periods lead to multiple oscillatory fluid flow induced intracellular calcium
oscillations in osteoblastic cells. Proc ASME Summer Bioeng Conf, p 705,
2003.
Godin LM, Donahue HJ, Jacobs CR, Donahue SW. Calcium fingerprints in
bone cell mechanotransduction. Trans Orthop Res Soc, 28: 679, 2003.
Godin LM, Donahue HJ, Jacobs CR, Donahue SW. Characteristics of
intracellular calcium oscillations in osteoblatic cells during repetitive
loading conditions. Proc ASME Summer Bioeng Conf, p 1057, 2003.
Haut-Donahue TL, Donahue H, Jacobs CR, Yellowley C. Annexin V
contributes to mechanotransduction in osteoblast-like cells. Trans Orthop
Res Soc, 27: 577, 2002.
Jair KY, Batra NN, You L, Jacobs CR. Dynamics of F-actin cytoskeleton
reorganization under loading-induced oscillatory fluid flow in MC3T3-E1
pre-osteoblasts. Proc ASME Summer Bioeng Conf, p 697, 2003.
Kingery W, Offley S, Guo T-Z, Joseph A, Lindsey D, Jacobs CR. Capsaicin
sensitive sensory neurons maintain normal bone integrity. 25th Ann Mtg Amer
Soc Bone and Mineral Res, Minneapolis, MN, Sep, 2003.
Li YJ, Batra N, Yellowley CE, Jacobs CR. Effects of fluid induced
oscillatory shear stress on human marrow stromal cell differentiation. Trans
Orthop Res Soc, 28: 680, 2003.
You L, Li YJ, Batra NN, Jacobs CR. The effect of oscillatory fluid flow
on human marrow stomal cell proliferation. Proc ASME Summer Bioeng Conf,
p 267, 2003.
You L, Li YJ, Batra NN, Jacobs CR. Design of a 3D Microfluidic system
for loading fluid flow on osteocyte processes in vitro. Proc ASME Summer
Bioeng Conf, p 695, 2003.
Bergandi JA, Rumi MN, Saunders MM, Jacobs CR, Pellegrini VD.
Periprosthetic osteolysis in a rabbit model: a comparison of latency to onset
in cemented and cementless knee implants. Trans Orthop Res Soc, 26:
1082, 2001.
Donahue SW, Jacobs CR, Donahue HJ. Mechanosensitivity of rat
osteoblastic cells is a function of age, loading frequency, and shear stress.
Trans Orthop Res Soc, 26: 564, 2001.
Saunders MM, You J, Trosko J, Yamasaki H, Donahue HJ, Jacobs CR.
Oscillatory flow induced prostaglandin E2 production is dependent upon gap
junctional intercellular communication in osteoblastic MC3T3-E1 cells. Trans
Orthop Res Soc, 26: 565, 2001.
You J, Saunders MM, Yellowley CE, Donahue HJ, Jacobs CR. Oscillatory
flow stimulates prostaglandin E2 release via protein kinase A in MC3T3-E1
osteoblasts involving cyclooxygenase-2. Trans Orthop Res Soc, 26: 326,
2001.
You J, Saunders MM, Yellowley CE, Donahue HJ, Jacobs CR. Torsion and
bending evaluation of femoral allograft fixation techniques in a cadaveric
model: a comparison of double plate to IM nail and plate fixation. Trans
Orthop Res Soc, 26: 523, 2001.
Book Chapter
Wimmer MA, Andriacchi TP. The basic science of human motion and its
relevance to wear and failure in total knee arthroplasty. In: Joint
Replacements and Bone Resorption: Pathology, Biomaterials and Clinical
Practice, eds: Shanbhag A, Rubash H, Jacobs J. New York: Marcel Dekker,
2001.
Invited Lectures
Jacobs CR. Mechanisms of cellular mechanosensitivity. Gordon Conf
Cartilage Biology and Pathology, Venture, CA, Mar, 2003.
Jacobs CR. Cellular mechanotransduction in bone. University of
California, Davis, CA, Apr, 2003.
Jacobs CR. Cellular mechanotransduction in bone. Dept Endocrinology,
University of California, San Francisco, CA, May, 2003.
Jacobs CR. Cellular mechanotransduction in bone. Stanford-Guidant
Lecture Series, Sep, 2003.
Jacobs CR. Topic in biomechanics: cell mechanics. Sun Valley Hard
Tissue Workshop, Sun Valley, ID, Aug 14-18, 2000.
Data Ready for Publication
Batra NN, Shivaram G, Kwon R, You L, Chi-Hyun RJ, Malone A, Jair K, and
Jacobs CR: The Role of the Actin Cytoskeleton in Oscillatory Fluid Flow Induced
Signaling in MC3T3-E1 Osteoblasts. American Journal of Physiology-Cell,
Submitted.
Fernandes PR, Folgado J, Jacobs CR, and Pellegrini VD: Influence of
Femoral Stem Geometry, Material, and Extent of Porous Coating on Bone Ingrowth
and Atrophy in Cementless Total Hip Arthroplasty: An Iterative Finite Element
Model. Journal of Bone and Joint Surgery, Submitted.
Kim C, Yellowley CE, and Jacobs CR: Oscillatory Fluid Flow Induced Shear
Stress Decreases Osteoclastogenic Activity through Regulation of RANKL and OPG.
Bone, Submitted.
Offley SC, Guo TZ, Wei T, Min E, Lindsey DP, Jacobs CR, and Kingery WS:
Unilateral immobilization induces regional reductions in trabecular bone
integrity and sensory neuronal signaling, Submitted.
Rubin J, Rubin C, and Jacobs CR: Mechanical signaling in bone.
Gene, Accepted.
You L, Temiyasathi S, Lee P, Kim C, Tummala P, Yao W, Kingery WS, and
Jacobs CR: Osteocytes as Mechanosensors in the Inhibition of Bone Resorption
Due to Mechanical Loading. Proceedings of the National Academy of
Science. Submitted.
Jacobs CR, Bechtel JB, Davis BR, Naidu SH, Pellegrini VD. Fatigue
lifetime studies of a new bone cement formulation.
Updated 10/10/2007
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