Selected Publications

(click on names for a PDF file of the paper)

Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK (2012) A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proc. Natl. Acad. Sci. USA 109:19071-19078.

Harwell CC, Parker PRL, Gee SM, Okada A, McConnell SK, Kreitzer AC, Kriegstein AR (2012) Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation. Neuron 22:1116-1126.

Wilson SL, Wilson JP, Wang C, Wang B, McConnell SK (2011) Primary cilia and Gli3 regulate cerebral cortical size. Dev. Neurobiol. doi:10.1002/dneu.20985.

Eckler MJ, McKenna WL, Taghvaei S, McConnell SK, Chen B (2011) Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity. J. Comp. Neurol. 519:1829-1846.

Shieh JC, Schaar BT, McConnell SK (2011) Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons. PLoS ONE 6:e17802.

Cord BJ, Li J, Works M, McConnell SK, Palmer T, Hynes MA (2010) Characterization of axon guidance cue sensitivity of human embryonic stem cell-derived dopaminergic neurons. Molec. Cell Neurosci. 45:324-334.

Leone DP, Srinivasan K, Brakebusch C, McConnell SK (2010) The Rho GTPase Rac1 is required for proliferation of intermediate progenitors in the developing forebrain. Dev. Neurobiol. 70:659-678.

Haditsch U, Leone DP, Farinelli M, Chrostek-Grashoff A, Brakebusch C, Mansuy IM, McConnell SK, Palmer TD (2009) A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Molec. Cell. Neurosci. 41:409-419.

Chen B, Wang SS, Hattox AM, Rayburn H, Nelson SB, McConnell SK (2008) The Fezf2-Ctip2 genetic pathway regulates the fate choice of layer 5 subcortical projection neurons. Proc. Natl. Acad. Sci. USA 105:11382-11387.

Leone DP, Srinivasan K, Chen B, Alcamo E, McConnell SK (2008) The determination of projection neuron identity in the developing cerebral cortex. Curr. Opin. Neurobiol. 18:28-35.

Srinivasan S, Roosa J, Olsen O, Lee SH, Bredt DS, McConnell SK (2008) MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex. Development 135: 1781-1790.

Alcamo EA, Chirivella L, Dautzenberg M, Dobreva G, Fariñas G, Grosschedl R, McConnell SK (2008) SATB2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron 57:364-377.

Hayhurst M, Gore BB, Tessier-Lavigne M, McConnell SK (2008) Ongoing Sonic hedgehog signaling is required for dorsal midline formation in the developing forebrain. Devel. Neurobiol., 68:83-100.

Fernandes M, Gutin G, Alcorn H, McConnell SK, Hébert JM (2007) Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Development 134:3789-3794.

Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre P, Tessier-Lavigne M, McConnell SK (2006) Boc is a receptor for Sonic Hedgehog in the guidance of commissural axons toward the ventral midline. Nature 444:369-373.

Gutin G, Fernandes M, Ornitz D, McConnell SK, Hébert JM (2006) FGF signaling generates ventral telencephalic cells independently of SHH. Development 133: 2937-2946.

Storm E, Garel S, Borello U, Hébert JM, Martinez S, McConnell SK, Martin GR, Rubenstein JLR (2006) Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development 133:1831-1844.

Ohtsuka T, Imayoshi I, Kageyama R, McConnell SK (2006) Visualization of embryonic neural stem cells using Hes promoters in transgenic mice. Molec. Cell. Neurosci. 31:109-122.

Chen B, Schaevitz LR, McConnell SK (2005) Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc. Natl. Acad. Sci. USA 102:17184-17189.

Kawauchi S, Shou J, Santos R, Hébert JM, McConnell SK, Mason I, Calof AL (2005) Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development 132:5211-5223.

Schaar BT, McConnell SK (2005) Cytoskeletal coordination during neuronal migration. PNAS 102:13652-13657.

Friedel RH, Plump A, Lu X, Spilker K, Jolicoeur C, Wong K, Venkathesh TR, Yaron A, Hynes M, Chen B, Okada A, McConnell SK, Rayburn H, Tessier-Lavigne M (2005) Gene targeting using a promoterless gene trap vector (“targeted trapping”) is an efficient method to mutate a large fraction of genes. PNAS 102:13188-13193.

Sansom SN, Hébert JM, Thammongkol U, Smith J, Nisbet G, Surani MA, McConnell SK, Livesey FJ (2005) Genomic characterisation of an FGF-regulated gradient-based cortical protomap. Development 132:3947-61.

Schaar BT, Kinoshita K, McConnell SK (2004) Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons. Neuron 41:203-213.

Hayhurst M, McConnell SK (2003) Mouse models of holoprosencephaly. Curr. Opin. Neurol. 16:135-141.

Hébert JM, Hayhurst M, Marks ME, Kulessa H, Hogan BLM, McConnell SK (2003) BMP ligands act redundantly to pattern the dorsal telencephalic midline. Genesis 35:214 -219.

Hébert JM, Lin M, Partanen J, Rossant J, McConnell SK (2003) FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. Development 130:1101-1111.

Hébert JM, Mishina Y, McConnell SK (2002) BMP signaling is required locally to pattern the dorsal telencephalic midline. Neuron 35:1029-1041.

Ferguson KL, Vanderluit JL, Hébert JM, McIntosh WC, Tibbo E, Park DS, Wallace V, Vooijs M, McConnell SK, Slack RS (2002) Telencephalic-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal forebrain development. EMBO J. 21: 3337-3346.

Pirvola U, Ylikoski J, Trokovic R, Hébert J, McConnell SK, Partanen J (2002) FGFR1 is required for the development of the auditory sensory epithelium. Neuron 35: 671-680.

Anderson SA, Kaznowski CE, Horn C, Rubenstein JL, McConnell SK (2002) Distinct origins of neocortical projection neurons and interneurons in vivo. Cereb. Cortex 12:702-709.

Zhang YA, Okada A, Lew CH, McConnell SK (2002) Regulated nuclear trafficking of the homeodomain protein Otx1 in cortical neurons. Molec. Cell. Neurosci. 19:430-446.

Aumais JP, Tunstead JR, McNeil R, Schaar BT, McConnell SK, Lin S-H, Clark GD, Yu-Lee LY (2001) NudC associates with Lis1 and the dynein motor at the leading pole of migrating neurons. J. Neurosci. 21: RC187.

Friocourt G, Chafey P, Billuart P, Koulakoff A, Vinet MC, Schaar B, McConnell SK, Francis F, Chelly J (2001) Doublecortin interacts with µ subunits of clathrin adaptor complexes in the developing nervous system. Molec. Cell. Neurosci. 18:307-19.

Cahana A, Escamez T, Nowakowski RS, Hayes NL, Giacobini MB, von Holst A, Shmueli O, Sapir T, McConnell SK, Wurst W, Martinez S, Reiner O (2001) Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. Proc. Natl. Acad. Sci. USA 98:6429-6434.

Chenn A, Levin ML, McConnell SK (2001) Restricted cerebral cortex expression of a candidate G-protein coupled receptor isolated by PCR differential display. J. Neurobiol. 46:167-177.

Mulieri PJ, Okada A, Sassoon DA, McConnell SK, Krauss RS (2000) Developmental expression pattern of the cdo gene. Devel. Dynamics 219:40-49.

Hébert JM, McConnell SK (2000) Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Devel. Biol. 222:296-306.

Xu B, Zang K, Raff NL, Antonini A, Zhang YA, McConnell SK, Stryker MP, Reichardt LF (2000) Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the neurotrophin receptor TrkB. Neuron 26:233-245.

Desai AR, McConnell SK (2000) Progressive restriction in fate potential by neural progenitors during cerebral cortical development. Development 127:2863-2872.

Weimann JM, Zhang YA, Levin ME, Devine P, Brulet P, McConnell SK (1999) Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets. Neuron 24:819-831.

Mackarehtschian K, Lau CK, Caras I, McConnell SK (1999) Regional differences in the developing cerebral cortex revealed by ephrin-A5 expression. Cerebral Cortex 9:601-610.

Francis F, Koulakoff A, Boucher D, Chafey P, Schaar B, Vinet M-C, Friocourt G, McDonnell N, Reiner O, Kahn A, McConnell SK, Berwald-Netter Y, Denoulet P, Chelly J (1999) Doublecortin is a developmentally regulated, mictrotubule-associated protein expressed in migrating and differentiating neurons. Neuron 23:247-256.

Okada A, Lansford R, Weimann JM, Fraser SE, McConnell SK (1999) Imaging cells in the developing nervous system with retrovirus expressing modified Green Fluorescent Protein. Exp. Neurol. 156:394-406.

Chenn A, Zhang YA, Chang BT, McConnell SK (1998) Intrinsic polarity of mammalian neuroepithelial cells. Molec. Cell. Neurosci. 11:183-193.

Caric D, Gooday D, Hill RE, McConnell SK, Price DJ (1997) Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6. Development 124:5087-5096.

O'Rourke NA, Chenn A, McConnell SK (1997) Postmitotic neurons migrate tangentially in the cortical ventricular zone. Development 124:997-1005.

Bohner AP, Akers RM, McConnell SK (1997) Induction of deep layer cortical neurons in vitro. Development 124:915-923.

Frantz GD, McConnell SK (1996) Restriction of late cerebral cortical progenitors to an upper-layer fate. Neuron 17:55-61.

Chenn A, McConnell SK (1995) Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis. Cell 82:631-641.

O’Rourke NA, Sullivan DP, Kaznowski CE, Jacobs AA, McConnell SK (1995) Tangential migration of neurons in the developing cerebral cortex. Development 121: 2165-2176.

Frantz GD, Weimann JM, Levin ME, McConnell SK (1994) Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. J. Neurosci. 14: 5725-5740.

Frantz GD, Bohner AP, Akers RM, McConnell SK (1994) Regulation of the POU-domain gene SCIP during cerebral cortical development. J. Neurosci. 14:472-485.

O'Rourke NA, Dailey ME, Smith SJ, McConnell SK (1992) Diverse migratory pathways in the developing cerebral cortex. Science 258:299-302.

McConnell SK, Kaznowski CE (1991) Cell cycle dependence of laminar determination in developing cerebral cortex. Science 254:282-285.

McConnell SK (1988) Fates of visual cortical neurons in the ferret after isochronic and heterochronic transplantation. J. Neurosci. 8:945-74.

McConnell SK (1985) Migration and differentiation of cerebral cortical neurons after transplantation into the brains of ferrets. Science 229:1268-1271.