Antimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms.

TitleAntimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms.
Publication TypeJournal Article
Year of Publication2011
AuthorsKapoor, R, Wadman MW, Dohm MT, Czyzewski AM, Spormann AM, Barron AE
JournalAntimicrobial agents and chemotherapy
Volume55
Issue6
Pagination3054-7
Date Published2011 Jun
ISSN1098-6596
AbstractThe resistance of biofilms to conventional antibiotics complicates the treatment of chronic cystic fibrosis (CF). We investigated the effects of peptoids, peptides, and conventional antibiotics on the biomass and cell viability within Pseudomonas aeruginosa biofilms. At their MICs, peptoids 1 and 1-C13(4mer) caused maximum reductions in biomass and cell viability, respectively. These results suggest that peptoids of this class could be worth exploring for the treatment of pulmonary infections occurring in CF patients.
Alternate JournalAntimicrob. Agents Chemother.
0 August 12, 2011