A chimeric prokaryotic ancestry of mitochondria and primitive eukaryotes.

TitleA chimeric prokaryotic ancestry of mitochondria and primitive eukaryotes.
Publication TypeJournal Article
Year of Publication1999
AuthorsKarlin, S, Brocchieri L, Mrázek J, Campbell AM, Spormann AM
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue16
Pagination9190-5
Date Published1999 Aug 3
ISSN0027-8424
KeywordsAmino Acid Sequence, Animals, Archaea, Bacteria, Chimera, Clostridium, DNA, Mitochondrial, Energy Metabolism, Eukaryotic Cells, Evolution, Heat-Shock Proteins, Humans, Mitochondria, Models, Genetic, Proteins, Sulfolobus, Vertebrates
AbstractWe provide data and analysis to support the hypothesis that the ancestor of animal mitochondria (Mt) and many primitive amitochondrial (a-Mt) eukaryotes was a fusion microbe composed of a Clostridium-like eubacterium and a Sulfolobus-like archaebacterium. The analysis is based on several observations: (i) The genome signatures (dinucleotide relative abundance values) of Clostridium and Sulfolobus are compatible (sufficiently similar) and each has significantly more similarity in genome signatures with animal Mt sequences than do all other available prokaryotes. That stable fusions may require compatibility in genome signatures is suggested by the compatibility of plasmids and hosts. (ii) The expanded energy metabolism of the fusion organism was strongly selective for cementing such a fusion. (iii) The molecular apparatus of endospore formation in Clostridium serves as raw material for the development of the nucleus and cytoplasm of the eukaryotic cell.
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
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