Metabolic Processes and Microbial Interactions in Human Intestinal Microbial Communities

Irritable Bowel Syndrome (IBS) is a chronic, episodic gastrointestinal disorder that is characterized by abdominal pain and altered bowel habits. IBS prevalence is estimated to be 10-15% in Western countries comprising 25 to 50 percent of all referrals to gastroenterologists. The gastrointestinal tract harbors a complex and diverse microbial community, which plays important roles in host nutrition, immune function, health and disease, and it is hypothesized the IBS disease phenotype is associated with a change in colonic microbiota and/or host factors such as mucosal function and immunity. This is strengthened by reports that luminal antibiotics or probiotic treatment may be effective in alleviating symptoms in patients with IBS. Indirect evidence for alterations in the microflora of humans with IBS comes from changes in colonic fermentation patterns have been described in patients with IBS. 

  • Microbial community and population structure associated with Irritable Bowel Syndrome
  • Metabolic interactions of gut microorganisms
0 September 21, 2010