Phone: 650 852 3220
Fax: 650 849 1983
Office: 3801 Miranda Ave, 154-W
Office: Bldg 4, Rm. B230
Office: Palo Alto, CA 94304
Dr. Tony Wyss-Coray
Over-expression of TGF-β1 has been demonstrated by Dr. Wyss-Coray to reduce Aβ deposition in brain parenchyma of APP transgenic mice. I am currently working on a drug-screening project searching for small-molecule compounds that mimic the beneficial effect of TGF-β1.
Research Scientist/Lab Manager
I moved to the States for graduate school in 1999. My thesis work focused on the role of oxidative injury in spinal cord injury and the protective effects of membrane repair on oxidative injury and mitochondria function. After I finished my Ph.D. project, I focused my research on neurodegeneration. I joined the Wyss-Coray’s lab in June of 2004 to pursue postdoctoral training and enjoy the California sunshine. I am interested in the cellular and molecular mechanisms of TGF-β signaling in brain injury and neurodegeneration. My current projects focus on (1) bioluminescence imaging of TGF-β signaling in the brain and (2) the role of TGF-β signaling in neurodegeneration and autoimmune encephalomyelitis.
I was trained as a cell biologist during my Ph.D. studies in Vienna, Austria at the Institute of Molecular Pathology (IMP) in the lab of Juergen Knoblich. In 2003, I moved to Stanford working in the lab of Liqun Luo as a postdoctoral fellow on developmental neurobiology, particularly interested in the assembly and maintenance of neural circuits. I joined the Wyss-Coray lab in January 2011. I am using proteomics approaches to discover novel signaling pathways associated with aging and neurodegenerative diseases.
Haley du Bois
My interests in Immunology began when I was still a master graduate student focusing on tumor immunology. My enthusiasm and continued interests in this field led me to work in industry where I mainly worked on development and production of ELISA Kits for metabolic syndrome biomarkers. After joining Wyss-Coray lab, I am currently working with Dr. Jian Luo and Dr. Eva Czirr on projects of treatment of Parkinson’s Disease and Frontotemporal Dementia using animal models.
I graduated from University of California, San Diego with a BS in Molecular Biology in 2010. I have worked in molecular biology, viral immunology, and in industry. Now I am working with Dr. Daniela Berdnik on proteomics/microarray projects.
As a graduate student in the lab of Josep Rizo at UT Southwestern, I used nuclear magnetic resonance (NMR) to determine a structural model of the Synaptotagmin-1-SNARE complex, four proteins key to achieving fast neurotransmitter release. A clear picture of this complex was elusive for over two decades, but I was able to uncover a highly dynamic structure that unified a large body of previous, often conflicting research on these proteins. In a structure-function collaboration with the lab of Thomas Südhof, we were able to also strongly support our model in neurons. Having a strong interest in aging, neurodegeneration, and learning and memory, I recently joined the Wyss-Coray lab in hopes of using novel experimental approaches to uncover mechanistic aspects of how the systemic environment influences the aging brain.
I received my graduate degree in Integrative Biology of Disease from the University of Southern California in 2015. For my thesis, I studied the role of T cells in pediatric brain cancer and also explored the role of innate immune TLR receptor signaling in Alzheimer's disease. For this work, I received an NIH NRSA F31 fellowship. I joined the Wyss-Coray lab in 2015 with a focus on understanding the role of epigenetics in microglia, the brain's innate immune cells. Simultaneously, I have begun exploring adaptive immunity in Alzheimer's disease in collaboration with the Stanford Brain Rejuvenation Project and Alzheimer 's Disease Research Center. I am a recipient of the Glenn/AFAR Postdoctoral Fellowship in the Biology of Aging and the Alzheimer's Association Young Investigator Award.
During my Ph.D. studies at the Blaise Pascal University, I used MEMRI (manganese-enhanced MRI) to try to understand how biologically relevant odors are processed in the brain of small animals. Then, I started a postdoc which is a collaboration between Roche Ltd (Basel, Switzerland) and the lab of Tony Wyss-Coray. We want to test the hypothesis that alterations in a multitude of markers measured in blood and CSF together with certain underlying genetic factors are linked to the pathological changes of the AD brain and can be used to predict progression. Through this project, we not only seek to increase our understanding of Alzheimer’s disease, but we hope to find new biomarkers which can be used for early diagnosis or monitoring the disease progression.
Tristan Qingyun Li
During my Ph.D. at the University of Salzburg, Austria, I studied muscle stem cells in adult zebrafish. For my post doc, having always been intrigued by the brain, I changed my research focus to neural stem cells and joined the Aigner lab (PMU Salzburg). Here I became interested in the identification of mechanisms that contribute to reduced neurogenesis and to neuroinflammation in aging. I could identify leukotrienes as key mediators for brain aging and showed that its pharmacological inhibition ameliorated neuroinflammation and improved cognition in aged rats.
I joined the Wyss-Coray lab in August 2015 to further explore the role of microglia in brain aging. Specifically, I aim to understand the role of microglial lipid accumulations in structural and functional brain aging. Also, I started to work on the killifish as a new model to study microglia and brain aging.
In my Ph.D, I used yeast as a model system to study prions and amyloids, which is how I developed an interest in protein aggregation diseases and neurodegeneration. Currently, I work on the involvement and modulation of microglia in neurodegenerative diseases like HD and FTD.
My dissertation research at UC Berkeley focused on elucidating changes in TGF-β and BMP signal transduction that underlie the decline of adult neural and muscle stem cell function and tissue regeneration with aging, and developing novel methods for rejuvenating the aged stem cell microenvironment. I joined the Wyss-Coray lab in April 2014 to delve further into the molecular mechanisms and cellular interactions that mediate brain aging, with a particular interest in the inhibitory effects of a pro-inflammatory aged systemic milieu and cross-talk between brain vasculature and the hippocampal neurogenic niche.
I am an MD-PhD student in the MSTP program. Prior to joining the Wyss-Coray lab, I worked in Irv Weissman’s lab investigating the pathogenesis of and immunotherapies for myelodysplastic syndrome. I am interested in the role of microglia and peripheral myeloid cells in aging.
I am interested in understanding how systemic changes contribute to aging. Before joining the Wyss-Coray lab, I worked in the lab of Judy Campisi on characterizing senescent cells and chemical inhibitors of the pro-inflammatory secretory phenotype. Currently, I am exploring how changes to the periphery with age promote cognitive decline.
I am a PhD student in the Chemical Engineering Department. Prior to joining the lab, I worked in Jim Swartz’s group here at Stanford on engineering virus-like particles for targeted delivery of cancer therapeutics. I am interested in gaining a better overall understanding of aging and inflammation, and then utilizing that understanding to generate therapeutics to treat these diseases.
Steven grew up in Sammamish, WA. He earned his BS in chemistry at UC Berkeley under Richmond Sarpong, doing research in synthetic organic chemistry. After an internship in medicinal chemistry at GlaxoSmithKline and three years studying synthesis and biophysics of lipids in the Burns lab at Stanford, Steven joined the Wyss-Coray lab to study the proteomics of aging.
Drew graduated from Stanford in 2017 after receiving a bachelor's degree and departmental honors in neurobiology. In the Wyss-Coray lab, he is working to understand the impact of physical exercise on brain health at the molecular and cellular level. At Stanford, Drew also competed for the varsity men's gymnastics team, which he captained his junior and senior years. In the future, he hopes to pursue a dual MD/PhD program, focusing on neuroscience.
Research Data Analyst