1951--Isoloation of a virus which would later be classified as a
reovirus (type 3) was made by Stanley, Dorman, and Ponsford from a young
1953--An ECHO 10 virus, which would later become the prototypic reovirus
serotype 1 strain, was isolated from a rectal swab taken from a healthy
1959--Proposal by Sabin that a group of previously classified members of
the echovirus 10 group be reclassified in a new family. He proposed the
name reovirus (respiratory, enteric, orphan virus) as the virus was not
known to cause any known disease state.
1960-- An outbreak of infection with T1 reoviurses among children in a
welfare institution in Washington D.C. was documented by Rosen and
1960s--Unique virion of the RNA of the Reoviridae family was discovered.
Early 1970s--Orboviruses, which were previouldy classified as
"unclassified arboviruses," were included in the Reoviridae family.
1973-- Bishop and co-workers discovered the 70 nm human rotavirus and its
association with severe diarrhea in infants and young children.
Mid-late 1970s--Rotaviruses also became part of the Reoviridae family as
realized that they had a segmented dsRNA genome. Three other genera which
infect insects and plants (Cypovirus, Phytoreovirus, Fijivirus) which also
have dsRNA became included in the Reoviridae family.
1978--Oral Rehydration therapy (ORT) was found to be useful in treating
preventing most of the deaths due to Rotavirus. Previous to this treatment
for severe Rotavirus was intravenous electrolyte replacement, a costly and
largely unavailabe treatment to those in need. The World Health
Organization (WHO) began promoting it extensively.
1998--Found Rotaviruses cause as many as one million hospitalizations and
500 deaths per year in the US.
1997--A rotavirus ELISA was developed by Robert Yolken and co-workers.
1998--A tetravalent vaccine was approved by the FDA for use in infants.