Condylox is the brand name for the drug podofilox produced by
Oclassen Pharmaceuticals, Inc. It is an antimitotic drug the can be
synthesized or purified from the plant families Coniferae and
Berberidaceae. It is available as a gel which is used for
topical adminstration only in the treatment of anogenital warts.
The exact mechanism of action is unknown. Visible necrosis of wart
tissue is visible in treatment of anogenital warts.
Condylox is indicated for treatment of anogenital warts (external
genital warts and perianal warts).
Condylox is not to be used to treat mucous membrane warts. The gel
should be applied twice daily for 3 consecutive days, then discontinuted for 4
consecutive days. The gel should be allowed to dry before touching opposing skin
surfaces. This one week cycle can be repeated until visible wart tissue has
disappeared. Treatment should be discontinued if no visible change occurs after
four treatment cycles. Application should be minimized to surrounding tissue,
and treatment should be limited no more than 10 sq. cm of wart tissue and no
more than 0.5 g of gel per day.
No studies have been done regarding the safety and efficacy of
treating warts on mucous membranes (including the urethra, vagina, and
rectum). Patients should be advised to follow physicians' instructions
at all times. This drug is flammable and should be kept away from open
Condylox is contraindicated for any patients who develop
hypersensitivity to the drug.
Potential Adverse Effects
The most commonly reported adverse effects were local irritation of
the skin, including inflammation, burning, erosion, pain, itching, and