HUMAN ASTROVIRUS SEROTYPES 1-8
A colorized electron micrograph of astrovirus.
- Immunofluorescence tests and enzyme immunoassays have demonstrated the serotype-specificity of antiserum derived from animals immunized with human serotypes 1-7.
- A monoclonal antibody produced by Herrmann et al. has served as a capture antibody in enzyme immunoassays in numerous seroepidemiologic studies. This monoclonal antibody targets a viral structural protein and recognizes all 7 human serotypes.
Serotypes detected in different geographic areas
In general, serotype 1 appears to be the most prevalent strain, but serotype 4 has been associated with severe gastroenteritis in young adults.
- Serotype 1 appears to be the prevalent strain in the UK. It is most common in Europe, the US, Australia, and Japan.
- In Europe, serotype 3 is second or third most common.
- Serotypes 3 and 4 are increasing in importance in the UK.
- Serotype 2 appears to be prevalent in Mexico, and type 1 appears to be relatively rare.
- In Japan, food-borne outbreaks of serotype 6 have affected thousands of children and adults.
- In the US, human serotypes 1-5 have been detected.