Drug Profile: Ribavirin
Ribavirin is an antiviral used to treat severe viral pneumonia in infants and young children, hepatitis C, RSV and it seems to reduce mortality in patients having Hemmorrhagic Fever with Renal Syndrome (HFRS). It has also been shown to have in vitro activity against HSV and influenza A and B but the clinical significance of these findings has not been determined.
Mechanism of Action:
Ribavirin is a synthetic guanine analogue that acts on messenger RNA and nucleotide metabolism. The exact mechanism of action is unknown.
Ribavirin can be given orally, through inhalation, or intravenously.
Typical adult dosage: Administer as aerosol; or 4 g i.v. or p.o daily
Typical pediatric dosage:
For RSV: Administer as aerosol (1.1 g/day).
For systemic (i.v.) use:
30 mg/kg as single dose
Then 16 mg/kg Q6h X 4 days
Then 8 mg/kg Q8h X 6 days
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