Update 2000

  Virus Profiles

  Pathogen Cards
    St. Louis Encephalitis

  Drug Profile
    AZdU (CS-87)


  Web Links

  Elizabeth Salas &
  Melissa Valadez
  Humans and Viruses
  Human Biology 115A
  Winter, 2000
  Robert Siegel,

  Date completed: 3/6/00
AZdU (CS-87)

3'-Azido-2',3'dideoxyuridine (AzdU or CS-87) is a nucleoside analog that has been shown to inhibit HIV replication in blood cells. The antiviral drug is thought to competitively inhibit reverse transcriptase of HIV by terminating the new DNA sequences made. AzdU has been shown to have a low level of toxicity to bone marrow cells while decreasing replication specifically in the peripheral blood mononuclear cells. An advantage of AzdU is that is has been shown to pass through the blood-brain barrier which if proven successful could be an additional method of reducing HIV replication in the brain and spine. Progress on AzdU has been slow, AzdU has not been approved by the FDA, however it is still in clinical trial phases. AzdU is not a cure to HIV, but may result in lengthening the lives of those infected by HIV by slowing the progression of the disease.

Manouilov, KK; White, CA; Boudinot, FD; Fedorov, II; Chu, CK. Lymphatic distribution of 3'-azido-3'-deoxythymidine and 3'-azido-2',3'-dideoxyuridine in mice. Drug Metabolism and Disposition, 1995 Jun, 23(6):655-8.

Zhu Z, et al. Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs. Molecular Pharmacology. 1990 Dec;38(6):929-38.

Chu CK, et al. Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine. Journal of Medical Chemistry. 1990 Aug;33(8):2188-92.